Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yvonne Dempsie"'
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Pulmonary hypertension (PH) is a disease associated with vasoconstriction and remodelling of the pulmonary vasculature. Pulmonary artery fibroblasts (PAFs) play an important role in hypoxic-induced remodelling. Connexin 43 (Cx43) is involved in cellu
Externí odkaz:
https://doaj.org/article/59ba0b8e790446f59b541bcc24ffbc8e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 379 (2021)
Pulmonary hypertension is a serious clinical condition characterised by increased pulmonary arterial pressure. This can lead to right ventricular failure which can be fatal. Connexins are gap junction-forming membrane proteins which serve to exchange
Externí odkaz:
https://doaj.org/article/d8fecf5b62604b9db970fbf4febcde75
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1891 (2018)
Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1). Connexin (Cx)43 has been shown to be involved in cellular communicati
Externí odkaz:
https://doaj.org/article/4d33128e7cab417c8792cdda1cd48ae5
Publikováno v:
World Journal of Cardiology
Accumulation of macrophage “foam” cells, laden with cholesterol and cholesteryl ester, within the intima of large arteries, is a hallmark of early “fatty streak” lesions which can progress to complex, multicellular atheromatous plaques, invol
Autor:
Geeshath Jayasekera, Yvonne Dempsie, Jim Mullin, David J. Welsh, Lindsay Gallagher, Gerard Murphy
Publikováno v:
Pulmonary hypertension.
Publikováno v:
Heart Journal - SCF.
Background Connexins are membrane channel forming proteins that are critically involved in different aspects of vascular physiology and pathology. Connexins have a role in the systemic vasculature in mediating vasoreactivity and tissue morphology thr
Autor:
Margaret R. Cunningham, Yvonne Dempsie, Blair F. Johnston, Ben E.P. Veerman, Samantha-Joe McGivern, Patricia Martin, Susan Currie
Publikováno v:
Heart Journal - SCF.
Introduction Anthracyclines, such as doxorubicin, remain an important class of chemotherapeutic agent however their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity. Whilst most studies have focused on cardiomyocyt
Publikováno v:
Biochemical Society Transactions. 43:524-529
Pulmonary arterial hypertension (PAH) is a complex, multi-factorial disorder characterized by both constriction and remodelling of the distal pulmonary vasculature. This leads to increased pulmonary pressures and eventually right heart failure. Curre
Publikováno v:
Pulmonary Circulation and Pulmonary Vascular Disease.
Rationale: Pulmonary arterial hypertension (PAH) is a disease associated with increased pulmonary arterial pressure and is mediated by both constriction and remodelling of the pulmonary arteries. Connexins are a family of transmembrane proteins which
Publikováno v:
Pulmonary Circulation and Pulmonary Vascular Disease.
Background: Pulmonary hypertension is characterized by abnormal vasoconstriction and vascular remodelling. Cellular communications via gap junctions are important for control and coordination of vascular function. Connexin 43 (Cx43) is the predominan