Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yvonne Will"'
Publikováno v:
Biology, Vol 8, Iss 2, p 32 (2019)
Mitochondrial function declines with age, leading to a variety of age-related diseases (metabolic, central nervous system-related, cancer, etc.) and medication usage increases with age due to the increase in diseases. Drug-induced mitochondrial toxic
Externí odkaz:
https://doaj.org/article/277266a3157c419e98bd4e5d550a35ff
Autor:
William R Proctor, Sherry Ralston, Szczepan W Baran, Gorm Yoder, Brian R. Berridge, Kristin Fabre, Yvonne Will, Terry R. Van Vleet
Publikováno v:
Lab on a Chip. 20:1049-1057
Safety related drug failures continue to be a challenge for pharmaceutical companies despite the numerous complex and lengthy in vitro assays and in vivo studies that make up the typical safety screening funnel. A lack of complete translation of anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076b0fe9f6741c5106bc32ac5fb4e1c2
https://doi.org/10.1039/c9lc01168d
https://doi.org/10.1039/c9lc01168d
Autor:
Yvonne Will, Philip Hewitt, Hartmut Jaeschke, Hilmi Orhan, Mathieu Vinken, Kendall B. Wallace
Publikováno v:
Applied In Vitro Toxicology. 5:167-172
Mitochondria play critical roles in all cell types. They are involved in processes such as calcium storage and signaling, cell proliferation, apoptosis, steroid synthesis, immunity, energy balance, and heat production. Inherent to these vital functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56f70206754245ddb12c0b59630062f
https://doi.org/10.1089/aivt.2019.29022.rtl
https://doi.org/10.1089/aivt.2019.29022.rtl
Autor:
James Hartke, Sarah Robertson, S. Aubrey Stoch, Matthew S. Bogdanffy, Dolores Diaz, Mazin Derzi, Elisabeth Mortimer‐Cassen, Peggy Guzzie-Peck, Lynne Butler, Joseph J. DeGeorge, Yvonne Will, Nigel Greene
Publikováno v:
Clinical Pharmacology & Therapeutics. 103:566-569
The European Medicines Agency (EMA) in 2017 issued a revised guideline on nonclinical and clinical aspects of first-in-human (FIH) and early clinical trials (CTs). External input was solicited during a draft comment phase, and although some industry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053b7d6ab71e814c4aa2806c9ce15fc4
https://doi.org/10.1002/cpt.984
https://doi.org/10.1002/cpt.984
Autor:
Bosung Ku, Jonathan S. Dordick, Kyeong-Nam Yu, Payal Rana, Moo-Yeal Lee, Alexander Roth, Sashi Nadanaciva, Dong Woo Lee, Yvonne Will
Publikováno v:
Archives of Toxicology. 92:1295-1310
Human liver contains various oxidative and conjugative enzymes that can convert nontoxic parent compounds to toxic metabolites or, conversely, toxic parent compounds to nontoxic metabolites. Unlike primary hepatocytes, which contain myriad drug-metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa90a734816880c5d234ea1a6c139a01
https://doi.org/10.1007/s00204-017-2126-3
https://doi.org/10.1007/s00204-017-2126-3
Autor:
Yvonne Will, Mazin Derzi, James Hartke, Dolores Diaz, Elisabeth Mortimer-Cassen, Nigel Greene, Peggy Guzzie-Peck, Lynne Butler, Matthew S. Bogdanffy, Joseph J. DeGeorge
Publikováno v:
Regulatory Toxicology and Pharmacology. 87:S1-S15
The transition from nonclinical to First-in-Human (FIH) testing is one of the most challenging steps in drug development. In response to serious outcomes in a recent Phase 1 trial (sponsored by Bial), IQ Consortium/DruSafe member companies reviewed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860c3900af078b039a4289adcb29f558
https://doi.org/10.1016/j.yrtph.2017.05.009
https://doi.org/10.1016/j.yrtph.2017.05.009
Autor:
Douglas A. Keller, Brian R. Berridge, Ananthsrinivas Chakilam, Yvonne Will, Monicah A. Otieno, Kristin M. Fabre, David B. Duignan, Yvonne P. Dragan, Lorna Ewart, Terry R. Van Vleet, Danilo A. Tagle, Claire G. Jeong, Jinping Gan, Peggy Guzzie-Peck, Jonathan A. Phillips, Jeetu Eswaraka, Sonia M. de Morais, David E. Watson, Radhakrishna Sura, William R Proctor
Publikováno v:
Experimental Biology and Medicine. 242:1579-1585
Tissue chips are poised to deliver a paradigm shift in drug discovery. By emulating human physiology, these chips have the potential to increase the predictive power of preclinical modeling, which in turn will move the pharmaceutical industry closer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128a14f0b4ce35a220ee4e7ecd5eeff
https://doi.org/10.1177/1535370217715441
https://doi.org/10.1177/1535370217715441
Autor:
A. David Rodrigues, Louis Leung, Hugh A. Barton, Michael D. Aleo, Yvonne Will, Sarah Lazzaro, R. Scott Obach, Chester Costales, Scott W Allen, Falgun Shah, Andrea Nilson
Publikováno v:
Chemical research in toxicology. 33(1)
The hepatic risk matrix (HRM) was developed and used to differentiate lead clinical and back-up drug candidates against competitor/marketed drugs within the same pharmaceutical class for their potential to cause human drug-induced liver injury (DILI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaeb8e8c2a6f0dbfe2267ce39d67fac
https://pubmed.ncbi.nlm.nih.gov/31532188
https://pubmed.ncbi.nlm.nih.gov/31532188
Publikováno v:
Chemical research in toxicology. 32(1)
Mitochondrial toxicity has been shown to contribute to a variety of organ toxicities such as liver, cardiac, and kidney. In the past decades, two high-throughput applicable screening assays (isolated rat liver mitochondria; glucose-galactose grown He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7305af369f64e1800d4fe407a560b877
https://pubmed.ncbi.nlm.nih.gov/30525499
https://pubmed.ncbi.nlm.nih.gov/30525499
Autor:
Yvonne Will, James Hynes
Publikováno v:
Mitochondrial Biology and Experimental Therapeutics ISBN: 9783319733432
Safety-related clinical attrition is of particular concern for the pharmaceutical industry due to the significant financial implications associated with late-stage failures. Considerable efforts have therefore been made over the past decade to addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf7773630d828a05d215f44e9cb76319
https://doi.org/10.1007/978-3-319-73344-9_15
https://doi.org/10.1007/978-3-319-73344-9_15
