Zobrazeno 1 - 2
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pro vyhledávání: '"Yvon Hervouet"'
Autor:
Jean-François Giffard, Christophe Hardouin, Peng Zhang, Frédéric Pin, Solenn Janvier, Julien Picard, Yvon Hervouet, Nathalie Pinault, Bruno Schiavi, Xueyan Zhu, Weiwei Zhao, Julie Hublet, Christine Penloup
Publikováno v:
Organic Process Research & Development. 23:1932-1947
This work describes the process development and manufacture of an ampakine-type active pharmaceutical ingredient in clinical trials. A regioselective CDI-mediated amidation process was optimized fo...
Autor:
François Barière, Yvon Hervouet, Christophe Hardouin, Patrick Mouchet, Aurélie Poixblanc, Thierry Dubuffet, Rodolphe Tamion
Publikováno v:
Organic Process Research & Development. 22:1419-1425
A new manufacturing process for N-[[1-(methylamino)cyclopropyl]methyl]pyridine-3-amine hemigalactarate (1) has been developed. Herein we wish to report the development and optimization of the route using alternative reaction conditions for a reductio