Výsledky vyhledávání - "Yvette M. van Aesch"

Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia

Autor: Yvette M. van Aesch, Anita M. Schelen, Alister C. Ward, Ivo P. Touw

Publikováno v: Blood, 93(2), 447-458. American Society of Hematology

Acquired mutations truncating the C-terminal domain of the granulocyte colony-stimulating factor receptor (G-CSF-R) are found in about 20% of severe congenital neutropenia (SCN) patients, with this cohort of patients predisposed to acute myeloid leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb80dbedf0c6c667ff314400adece5a0
https://doi.org/10.1182/blood.v93.2.447

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Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration

Autor: Yvette M. van Aesch, Anita M. Schelen, Ivo P. Touw, Alister C. Ward, Mirjam H. A. Hermans, Louise Smith, Claudia Antonissen

Publikováno v: Blood, 93(1), 113-124. American Society of Hematology

The granulocyte colony-stimulating factor receptor (G-CSF-R) activates multiple STAT proteins. Although the membrane-proximal cytoplasmic region of the G-CSF-R is necessary and sufficient for activation of STAT1 and STAT5, activation of STAT3 require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dedb2806bc14ef820320c617c0588d
https://doi.org/10.1182/blood.v93.1.113.401k33_113_124

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Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells

Autor: Yvette M. van Aesch, Alister C. Ward, Louise Smith, John P. de Koning, Ivo P. Touw

Publikováno v: Journal of Biological Chemistry, 274(21), 14956-14962. American Society for Biochemistry and Molecular Biology Inc.

Granulocyte colony-stimulating factor (G-CSF) regulates neutrophil production through activation of its cognate receptor, the G-CSF-R. Previous studies with deletion mutants have shown that the membrane-proximal cytoplasmic domain of the receptor is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0e169b453590ae8aef1390c2aa6f5d
https://doi.org/10.1074/jbc.274.21.14956

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Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G CSF treatment

Autor: Judith Gits, John P. de Koning, Daphne van Leeuwen, Melvin H. Freedman, Anita M. Schelen, Alister C. Ward, Yvette M. van Aesch, Ivo P. Touw

Publikováno v: Journal of Experimental Medicine, 190(4), 497-507. Rockefeller University Press
The Journal of Experimental Medicine

Severe congenital neutropenia (SCN) is a heterogeneous condition characterized by a drastic reduction in circulating neutrophils and a maturation arrest of myeloid progenitor cells in the bone marrow. Usually this condition can be successfully treate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a17586f1f17e87a49bce69487d52e34
https://pure.eur.nl/en/publications/cf330f8a-7802-4dae-b6d7-ddbc72451d6d

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