Výsledky vyhledávání - "Yvette M. Delahoussaye"

Metabolism of tirapazamine by multiple reductases in the nucleus11Abbreviations: TPZ, tirapazamine; P450 reductase, NADPH:cytochrome P450 reductase; PMSF, phenylmethylsulfonyl fluoride; DTT, dithiothreitol; DHR123, dihydrorhodamine 123; DAPI, 4′,6-diamidino-2-phenylindole, dihydrochloride; SN, supernatant from nuclei; LS, low salt; HS, high salt; and NM, nuclear matrix

Autor: J. Martin Brown, Yvette M. Delahoussaye, James W. Evans

Publikováno v: Biochemical Pharmacology. 62:1201-1209

Tirapazamine (TPZ, 3-amino-1,2,4-benzotriazine 1,4-di-N-oxide, SR4233, Tirazone), a bioreductive drug currently in clinical trials, is selectively toxic to hypoxic cells commonly found in solid tumors. The toxicity results from the intracellular meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e2ea22a6afd36e7b5a415ea262a96dd
https://doi.org/10.1016/s0006-2952(01)00784-5

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Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting

Autor: William A. Denny, Yvette M. Delahoussaye, Frederik B. Pruijn, Michael P. Hay, J. Martin Brown

Publikováno v: Biochemical pharmacology. 65(11)

To improve the potency of the hypoxic cytotoxin tirapazamine (TPZ), we have constructed an analog, SN26955, with the TPZ moiety attached to an acridine chromophore to target the drug to DNA. The underlying reason for this is our previous finding that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce45de9547a48bd38a46278d80e6666
https://pubmed.ncbi.nlm.nih.gov/12781332

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