Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yvette M, Fobian"'
Autor:
Louise Bernier, Gary Chinigo, Chulho Choi, Julien Genovino, Mark W. Bundesmann, Mathieu Frenette, Olugbeminiyi O. Fadeyi, Yohann Gagné, Neal W. Sach, Martins S. Oderinde, Antoine Juneau, Philippe Nuhant, Bhagyashree Khunte, Christophe Allais, Yvette M. Fobian
Publikováno v:
Angewandte Chemie (International ed. in English). 56(48)
A visible-light-driven Minisci protocol that employs an inexpensive earth-abundant metal catalyst, decacarbonyldimanganese Mn2 (CO)10 , to generate alkyl radicals from alkyl iodides has been developed. This Minisci protocol is compatible with a wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18494db170c7fa126bd9911a752ce461
https://pubmed.ncbi.nlm.nih.gov/28960645
https://pubmed.ncbi.nlm.nih.gov/28960645
Autor:
Anthony Wood, Simon Bailey, David Austen Perry, Heather N. Frost, Yvette M. Fobian, Sylvie K. Sakata, F. Christopher Bi, Xiaolan Ling, Leslie Sloan
Publikováno v:
Drug Discovery Today. 19:289-294
Confronted with the need to significantly raise the productivity of remotely located chemistry CROs Pfizer embraced a commitment to continuous improvement which leveraged the tools from both Lean Six Sigma and queue management theory to deliver posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d992a73f109b53b2684d53e89334534
https://doi.org/10.1016/j.drudis.2013.07.017
https://doi.org/10.1016/j.drudis.2013.07.017
Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting ar
Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation
Autor:
John Robert Springer, Gina M. Jerome, Hayes Michael J, Michael T. Baratta, Daniel P. Walker, Graciela B. Arhancet, Alexander F. Shaffer, Jaime L. Masferrer, Ben S. Zweifel, Steven E. Heasley, Darin E. Jones, William M. Moore, Jeffrey S. Carter, Yvette M. Fobian, Michael L. Vazquez, Sue Metz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1114-1119
Inhibition of mPGES-1, the terminal enzyme in the arachidonic acid/COX pathway to regulate the production of pro-inflammatory prostaglandin PGE2, is considered an attractive new therapeutic target for safe and effective anti-inflammatory drugs. The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b121fd58b89ecf308dd263c517c877ef
https://doi.org/10.1016/j.bmcl.2012.11.109
https://doi.org/10.1016/j.bmcl.2012.11.109
Autor:
Daniel P. Walker, Alexander F. Shaffer, William M. Moore, Michael T. Baratta, Sue Metz, Jeffrey A. Scholten, John Robert Springer, Jeffrey S. Carter, Hwang-Fun Lu, Steven E. Heasley, Yvette M. Fobian, Natasha M. Kablaoui, Francisco M. Franco, Li Xing, Shengtian Yang, Hanau Cathleen E, Michael L. Vazquez, Graciela B. Arhancet, Gina M. Jerome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1120-1126
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed the discovery of clinical candidate PF-04693627, a potent mPGES-1 inhibitor possessing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d05bf0698be13f2291735a95c4465f
https://doi.org/10.1016/j.bmcl.2012.11.107
https://doi.org/10.1016/j.bmcl.2012.11.107
Autor:
David C. Blakemore, Alexandria P. Taylor, Ralph P. Robinson, Yvette M. Fobian, Lyn H. Jones, Olugbeminiyi O. Fadeyi
Publikováno v:
ChemInform. 47
New advances in synthetic methodologies that allow rapid access to a wide variety of functionalized heterocyclic compounds are of critical importance to the medicinal chemist as it provides the ability to expand the available drug-like chemical space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c5868a74922979cf1b9017e6cb3343e
https://doi.org/10.1002/chin.201637183
https://doi.org/10.1002/chin.201637183
Autor:
Lyn H. Jones, Yvette M. Fobian, Alexandria P. Taylor, David C. Blakemore, Olugbeminiyi O. Fadeyi, Ralph P. Robinson
Publikováno v:
Organicbiomolecular chemistry. 14(28)
New advances in synthetic methodologies that allow rapid access to a wide variety of functionalized heterocyclic compounds are of critical importance to the medicinal chemist as it provides the ability to expand the available drug-like chemical space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a5704b2dd6f6e71cbabb3f1658751c
https://pubmed.ncbi.nlm.nih.gov/27282396
https://pubmed.ncbi.nlm.nih.gov/27282396
Autor:
Joe T. Collins, Steven E. Heasley, Hwang-Fun Lu, Yvette M. Fobian, Allison MacInnes, Michael K. Mao, Tizah Evelyn Anjeh, Michael L. Vazquez, Daniel P. Walker
Publikováno v:
Synlett. 2011:2959-2962
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aef523cf664fd44ce2716061f3401ac
https://doi.org/10.1055/s-0031-1289884
https://doi.org/10.1055/s-0031-1289884
Autor:
Michael A. Tones, Paul A. Bradley, Graham L. Smith, Lee R. Roberts, Geoff E. Gymer, Katherine S. England, Fox David Nathan Abraham, Steven E. Heasley, Michelle Schmidt, Mark E. Bunnage, Yvette M. Fobian, Jerome Molette, David Fairman, Dack Kevin Neil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6515-6518
A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54aefeeb064c19cd276466bf3d396d04
https://doi.org/10.1016/j.bmcl.2011.08.071
https://doi.org/10.1016/j.bmcl.2011.08.071