Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Yvette Drew"'
Publikováno v:
Gynecologic Oncology Reports, Vol 54, Iss , Pp 101439- (2024)
Olaparib, the first-in-class poly ADP-ribose polymerase (PARP) inhibitor, is approved for first line maintenance treatment in platinum-sensitive FIGO stage 3 and 4 high grade serous ovarian cancer (HGSOC) associated with a deleterious BRCA mutation.
Externí odkaz:
https://doaj.org/article/7e4ceb97ba6d498aa6e574d61c597129
Publikováno v:
Cells, Vol 11, Iss 15, p 2361 (2022)
Ataxia telangiectasia and Rad-3 related kinase (ATR) signals DNA lesions and replication stress (RS) to the S and G2/M checkpoints and DNA repair pathways making it a promising target to exploit the dysregulated DNA damage response in cancer. ATR inh
Externí odkaz:
https://doaj.org/article/00f48ebd7e9a4735b449b68c1e445217
Autor:
Miriam Franklin, Lucy Gentles, Elizabeth Matheson, Nick Bown, Paul Cross, Angela Ralte, Connor Gilkes‐Immeson, Alice Bradbury, Maryam Zanjirband, John Lunec, Yvette Drew, Rachel O'Donnell, Nicola J. Curtin
Publikováno v:
Cancer Medicine, Vol 7, Iss 9, Pp 4744-4754 (2018)
Abstract NUCOLL43 is a novel ovarian clear cell carcinoma (O‐CCC) cell line that arose from a primary culture of a patient's malignant ascites. The cells grow reliably in cell culture with a doubling time of approx. 45 hours and form colonies at hi
Externí odkaz:
https://doaj.org/article/cee3c4c7a6c049d1a597408b8c970ebc
Autor:
Sarah E. Fordham, Helen J. Blair, Claire J. Elstob, Ruth Plummer, Yvette Drew, Nicola J. Curtin, Olaf Heidenreich, Deepali Pal, David Jamieson, Catherine Park, John Pollard, Scott Fields, Paul Milne, Graham H. Jackson, Helen J. Marr, Tobias Menne, Gail L. Jones, James M. Allan
Publikováno v:
Blood Advances, Vol 2, Iss 10, Pp 1157-1169 (2018)
Abstract: The ataxia telangiectasia and Rad3-related (ATR) protein kinase promotes cancer cell survival by signaling stalled replication forks generated by replication stress, a common feature of many cancers including acute myeloid leukemia (AML). H
Externí odkaz:
https://doaj.org/article/61768a4bf39943d4a87bca41dd7f4f9c
Autor:
Rebecca S. Kristeleit, Yvette Drew, Amit M. Oza, Susan M. Domchek, Susana Banerjee, Rosalind M. Glasspool, Judith Balmaña, Lee-may Chen, Manish R. Patel, Howard A. Burris, Tamar Safra, Jennifer Borrow, Kevin K. Lin, Sandra Goble, Lara Maloney, Ronnie Shapira-Frommer
Publikováno v:
British Journal of Cancer. 128:255-265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ddbb016eb4cc600e10e751976a1515
https://doi.org/10.1038/s41416-022-02022-y
https://doi.org/10.1038/s41416-022-02022-y
Autor:
Sweta Sharma Saha, Lucy Gentles, Rachel Howarth, Stuart Rundle, Angela Ralte, Rachel O'Donnell, Nicola Curtin, Yvette Drew
Neoadjuvant chemotherapy (NACT) has been known to induce genomic and transcriptomic alterations within tumours. Here, using transcriptome profiling along with histological analysis of pre and post NACT, we show temporal and disease site-specific diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa0aa86705ffe0d75cbc693728752974
https://doi.org/10.21203/rs.3.rs-2840508/v1
https://doi.org/10.21203/rs.3.rs-2840508/v1
Autor:
Johann S. de Bono, Yvette Drew, Juanita S. Lopez, Bristi Basu, Ruth Plummer, Udai Banerji, Christopher J. Lord, Andrew Foxley, Justin P.O. Lindemann, Paul Rugman, Emma Hall, Laura Finneran, Karen E. Swales, Shaun Decordova, Florence I. Raynaud, Ruth Ruddle, Nicholas C. Turner, Heidrun Gevensleben, Neha Chopra, Nina Tunariu, Alison Turner, Mona Parmar, Ruth Matthews, Sarah Ward, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Rowan Miller, Desamparados Roda, Suzanne Carreira, Joline S.J. Lim, Stephen J. Pettitt, Vasiliki Michalarea, Rebecca Kristeleit, Timothy A. Yap
Preclinical studies have demonstrated synergy between PARP and PI3K/AKT pathway inhibitors in BRCA1 and BRCA2 (BRCA1/2)–deficient and BRCA1/2-proficient tumors. We conducted an investigator-initiated phase I trial utilizing a prospective intrapatie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01e33adbfd1faf3496d00cefbd4e1d17
https://doi.org/10.1158/2159-8290.c.6547955.v1
https://doi.org/10.1158/2159-8290.c.6547955.v1
Autor:
Johann S. de Bono, Yvette Drew, Juanita S. Lopez, Bristi Basu, Ruth Plummer, Udai Banerji, Christopher J. Lord, Andrew Foxley, Justin P.O. Lindemann, Paul Rugman, Emma Hall, Laura Finneran, Karen E. Swales, Shaun Decordova, Florence I. Raynaud, Ruth Ruddle, Nicholas C. Turner, Heidrun Gevensleben, Neha Chopra, Nina Tunariu, Alison Turner, Mona Parmar, Ruth Matthews, Sarah Ward, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Rowan Miller, Desamparados Roda, Suzanne Carreira, Joline S.J. Lim, Stephen J. Pettitt, Vasiliki Michalarea, Rebecca Kristeleit, Timothy A. Yap
Supplementary Tables 1-7; Supplementary Figures 1-2; Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b42dc1c2ce5b8015019651ef216b42
https://doi.org/10.1158/2159-8290.22535825
https://doi.org/10.1158/2159-8290.22535825
Autor:
Johann S. de Bono, Eleni Lagkadinou, Ruth Plummer, Sonal Bordia, Li Liu, Yinghui Zhou, Matthias Ludwig, Andreas Schlicker, Friedhelm Bladt, Antje M. Wengner, Joseph Hreiki, Gary Wilkinson, Funda Meric-Bernstam, David S. Hong, Yvette Drew, Saira Bashir, Noor R. Md. Haris, Valerie Heong, Boon Cher Goh, Christina Guo, Reece Caldwell, Angelika Terbuch, David S.P. Tan, Timothy A. Yap
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90163999376a8ed69826af5cc165e7d
https://doi.org/10.1158/2159-8290.22536568
https://doi.org/10.1158/2159-8290.22536568
Autor:
Johann S. de Bono, Eleni Lagkadinou, Ruth Plummer, Sonal Bordia, Li Liu, Yinghui Zhou, Matthias Ludwig, Andreas Schlicker, Friedhelm Bladt, Antje M. Wengner, Joseph Hreiki, Gary Wilkinson, Funda Meric-Bernstam, David S. Hong, Yvette Drew, Saira Bashir, Noor R. Md. Haris, Valerie Heong, Boon Cher Goh, Christina Guo, Reece Caldwell, Angelika Terbuch, David S.P. Tan, Timothy A. Yap
Targeting the ataxia telangiectasia and RAD3-related (ATR) enzyme represents a promising anticancer strategy for tumors with DNA damage response (DDR) defects and replication stress, including inactivation of ataxia telangiectasia mutated (ATM) signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a84ec86140d34e411d2f9130c9e04a
https://doi.org/10.1158/2159-8290.c.6548170.v1
https://doi.org/10.1158/2159-8290.c.6548170.v1