Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yvette Chin"'
Autor:
Paulina M. Wojnarowicz, Marta Garcia Escolano, Yun-Han Huang, Bina Desai, Yvette Chin, Riddhi Shah, Sijia Xu, Saurabh Yadav, Sergey Yaklichkin, Ouathek Ouerfelli, Rajesh Kumar Soni, John Philip, David C. Montrose, John H. Healey, Vinagolu K. Rajasekhar, William A. Garland, Jeremy Ratiu, Yuan Zhuang, Larry Norton, Neal Rosen, Ronald C. Hendrickson, Xi Kathy Zhou, Antonio Iavarone, Joan Massague, Andrew J. Dannenberg, Anna Lasorella, Robert Benezra
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation. A small-molecule, AGX51, t
Externí odkaz:
https://doaj.org/article/fcc94ce778e043e9991e8da7d30777e4
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1832-1845 (2017)
The mitotic checkpoint ensures proper segregation of chromosomes by delaying anaphase until all kinetochores are bound to microtubules. This inhibitory signal is composed of a complex containing Mad2, which inhibits anaphase progression. The complex
Externí odkaz:
https://doaj.org/article/5e83b95e59a7407e9048e2bae07c6bc5
Autor:
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 62-75.e7 (2019)
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to
Externí odkaz:
https://doaj.org/article/95d35ea0d3dd4fce8521d6c45f7d1b30
Autor:
Ning Zhang, Rhonda K. Yantiss, Hyung-song Nam, Yvette Chin, Xi Kathy Zhou, Ellen J. Scherl, Brian P. Bosworth, Kotha Subbaramaiah, Andrew J. Dannenberg, Robert Benezra
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 716-724 (2014)
LGR5 and BMI1 mark intestinal stem cells in crypt base columnar cells and +4 position cells, respectively, but characterization of functional markers in these cell populations is limited. ID1 maintains the stem cell potential of embryonic, neural, an
Externí odkaz:
https://doaj.org/article/41842e6905684377996d312aa01a4224
Autor:
Marko Stankic, Svetlana Pavlovic, Yvette Chin, Edi Brogi, David Padua, Larry Norton, Joan Massagué, Robert Benezra
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1228-1242 (2013)
ID genes are required for breast cancer colonization of the lungs, but the mechanism remains poorly understood. Here, we show that Id1 expression induces a stem-like phenotype in breast cancer cells while retaining epithelial properties, contrary to
Externí odkaz:
https://doaj.org/article/dc7f6d040cd548529fc729b6311ecddc
Autor:
Ning Zhang, Kotha Subbaramaiah, Rhonda K. Yantiss, Xi Kathy Zhou, Yvette Chin, Robert Benezra, Andrew J. Dannenberg
Publikováno v:
Cancer Prev Res (Phila)
Different mechanisms contribute to the development of sporadic, hereditary and colitis-associated colorectal cancer. Inhibitor of DNA binding/differentiation (Id) proteins act as dominant-negative antagonists of basic helix-loop-helix transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a814ac01e3204e4bd1058243f944447b
https://europepmc.org/articles/PMC9272563/
https://europepmc.org/articles/PMC9272563/
Autor:
Sijia Xu, Antonio Iavarone, Andrew J. Dannenberg, Robert Benezra, John H. Healey, Vinagolu K. Rajasekhar, William A. Garland, Marta Garcia Escolano, Ouathek Ouerfelli, Yun-Han Huang, Yvette Chin, David C. Montrose, Riddhi Shah, Xi Kathy Zhou, Anna Lasorella, John Philip, Bina Desai, Larry Norton, Rajesh K. Soni, Ronald C. Hendrickson, Neal Rosen, Joan Massagué, Paulina M. Wojnarowicz
SummaryId proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. Id proteins inhibit basic HLH transcription factors through protein-protein interactions, often inhibiting differentiation and sustaining pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f625321fdd98b3d30b8d9cdee8df39e7
https://doi.org/10.1101/2020.01.06.894840
https://doi.org/10.1101/2020.01.06.894840
Publikováno v:
The EMBO Journal. 37:201-218
Whole chromosome gains or losses (aneuploidy) are a hallmark of ~70% of human tumors. Modeling the consequences of aneuploidy has relied on perturbing spindle assembly checkpoint (SAC) components, but interpretations of these experiments are clouded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b80ab5301a4fb9cd997ae6cd744258
https://doi.org/10.15252/embj.201797630
https://doi.org/10.15252/embj.201797630
Autor:
Rhonda K. Yantiss, Xi Kathy Zhou, Kotha Subbaramaiah, Yvette Chin, Andrew J. Dannenberg, Robert Benezra, Ning Zhang
Publikováno v:
Cancer Prevention Research. 8:303-311
Different mechanisms contribute to the development of sporadic, hereditary and colitis-associated colorectal cancer. Inhibitor of DNA binding/differentiation (Id) proteins act as dominant-negative antagonists of basic helix–loop–helix transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e691d3b8ee12084012d9355a3ec53e36
https://doi.org/10.1158/1940-6207.capr-14-0411
https://doi.org/10.1158/1940-6207.capr-14-0411