The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions

Autor: Philippe Liere, Guo-Jun Liu, Antoine Pianos, Ryan J. Middleton, Richard B. Banati, Yvette Akwa

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 3, p 2474 (2023)

The 18 kDa translocator protein (TSPO/PBR) is a multifunctional evolutionary highly conserved outer mitochondrial membrane protein. Decades of research has reported an obligatory role of TSPO/PBR in both mitochondrial cholesterol transport and, thus,

Externí odkaz: https://doaj.org/article/77c9ec88cd5e4aaa8b4a0c3a39a670f2

Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

Autor: Yvette Akwa, Chiara Di Malta, Fátima Zallo, Elise Gondard, Adele Lunati, Lara Z. Diaz-de-Grenu, Angela Zampelli, Anne Boiret, Sara Santamaria, Maialen Martinez-Preciado, Katia Cortese, Jeffrey H. Kordower, Carlos Matute, Andres M. Lozano, Estibaliz Capetillo-Zarate, Thomas Vaccari, Carmine Settembre, Etienne E. Baulieu, Davide Tampellini

Publikováno v: TECNALIA Publications
Fundación Tecnalia Research & Innovation

Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of AD, and deep brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b560664b3ef223e7a7248c419986b6fe
http://hdl.handle.net/10810/59763

The mitochondrial translocator protein (TSPO): a key multifunctional molecule in the nervous system

Autor: Léa El Chemali, Yvette Akwa, Liliane Massaad-Massade

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2022, 479 (13), pp.1455-1466. ⟨10.1042/BCJ20220050⟩

International audience; Translocator protein (TSPO, 18 kDa), formerly known as peripheral benzodiazepine receptor, is an evolutionary well-conserved protein located on the outer mitochondrial membrane. TSPO is involved in a variety of fundamental phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f70e63c6a434f9ae026a1484167cff6
https://pubmed.ncbi.nlm.nih.gov/35819398

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease

Autor: Jérôme Braudeau, Nicola Salvatore Orefice, François Becher, Charlène Joséphine, Mickael Audrain, Benoit Souchet, Alexis Haddjeri, Yvette Akwa, Alexis-Pierre Bemelmans, Sandro Alves, Nathalie Cartier, Jean-Marie Billard, Thierry Delzescaux, Arthur Viode, Patrick Dutar, Brigitte Potier, Philippe Hantraye, Satoru Tada, Romain Fol, Nicole Déglon

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2018, 28 (11), pp.3976-3993. ⟨10.1093/cercor/bhx260⟩
Cerebral Cortex, 2018, 28 (11), pp.3976-3993. ⟨10.1093/cercor/bhx260⟩

The treatment of Alzheimer's disease (AD) remains challenging and requires a better in depth understanding of AD progression. Particularly, the link between amyloid protein precursor (APP) processing and Tau pathology development remains poorly under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f36518d433f4cacef5de9c131baa164
https://hal-normandie-univ.archives-ouvertes.fr/hal-02324980

Assessment of poststroke mania and diagnosis

Autor: Alain Lieury, Hervé Allain, Lucette Lacomblez, Yvette Akwa, Danièle Bentué-Ferrer

Publikováno v: Neuropsychiatric Disease and Treatment

Cognitive psychology has provided clinicians with specific tools for analyzing the processes of cognition (memory, language) and executive functions (attention-concentration, abstract reasoning, planning). Neuropsychology, coupled with the neuroscien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468f8f854d3f6a4cfb3d137bec93f408
http://europepmc.org/articles/PMC5328603