Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Yves T. Wang"'
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2617-2628 (2018)
Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II. Herein, using stable-isotope-res
Externí odkaz:
https://doaj.org/article/a1dc1048aabd47c6a5b6e7a8209630d9
Autor:
Emilie H. Lothet, Kendrick M. Shaw, Hui Lu, Junqi Zhuo, Yves T. Wang, Shi Gu, Donna B. Stolz, E. Duco Jansen, Charles C. Horn, Hillel J. Chiel, Michael W. Jenkins
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the
Externí odkaz:
https://doaj.org/article/ef485175ef8c4bb4ada77f91c156fa83
Autor:
Pei-Lun Chu, Joseph C. Gigliotti, Sylvia Cechova, Gabor Bodonyi-Kovacs, Yves T. Wang, Luojing Chen, Sylvia Wassertheil-Smoller, Jianwen Cai, Brant E. Isakson, Nora Franceschini, Thu H. Le
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F30-F42
The findings of our study are significant in several ways: 1) loss of an amino acid chaperone in the proximal tubule is sufficient to cause hypertension, 2) the results in global and proximal tubule-specific collectrin knockout mice support the notio
Autor:
Pei-Lun, Chu, Joseph C, Gigliotti, Sylvia, Cechova, Gabor, Bodonyi-Kovacs, Yves T, Wang, Luojing, Chen, Sylvia, Wassertheil-Smoller, Jianwen, Cai, Brant E, Isakson, Nora, Franceschini, Thu H, Le
Publikováno v:
American journal of physiology. Renal physiology. 324(1)
Collectrin (
Publikováno v:
Hypertension. 79
Hypertension (HTN) is highly prevalent and is a significant risk factor for CVD. Excessive vasoconstriction contributes to HTN. Recently, p90 ribosomal S6 kinase, isoform 2 (RSK2) signaling has been shown to play a significant role in the regulation
Autor:
Guang Yang, Yves T. Wang, Bing Yu, Gabor Bodonyi-Kovacs, Phillip Ruiz, Janet V. Cross, Anna Köttgen, Eric Boerwinkle, Megan L. Grove, Nhu T. Nguyen, Adrienne Tin, Sylvia Cechova, Fang Chan, Josef Coresh, Shirin Pourafshar, Casey M. Rebholz, Sun-Sang J. Sung, Joseph C. Gigliotti, Robert B. Scharpf, Morgan E. Grams, Thu H. Le
Publikováno v:
J Am Soc Nephrol
Background GSTM1 encodes glutathione S-transferase μ-1 (GSTM1), which belongs to a superfamily of phase 2 antioxidant enzymes. The highly prevalent GSTM1 deletion variant is associated with kidney disease progression in human cohorts: the African Am
Publikováno v:
Hypertension. 78
The glutathione S-transferase ( Gst ) gene family encodes antioxidant enzymes. In humans, a common null allele deletion variant of GST μ-1 ( GSTM1 ) is highly prevalent across populations and is associated with increased risk and progression of vari
Publikováno v:
Hypertension. 78
Nuclear Factor of Activated T Cells 1 (NFATC1) plays a role in the immune response and has been shown to be required for cardiac development. A recent trans-ethnic meta-analysis of genome-wide association studies (GWAS) found the NFATC1 gene in human
Autor:
Matthew N. McCall, Keith Nehrke, Yunki Lim, Yves T. Wang, Cole M. Haynes, Paul S. Brookes, Kai-Ting Huang
Publikováno v:
Am J Physiol Heart Circ Physiol
The mitochondrial unfolded protein response (UPRmt) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPRmt activation upregulates chaperones, proteases, antioxidants, and glycolysis at the gene level to restore proteostas
Publikováno v:
Hypertension. 76
Glutathione S-transferase μ-1 (GSTM1) is an enzyme that has a role in the detoxification of electrophiles, including xenobiotics and products of oxidative stress. In humans, the GSTM1(0) null allele deletion variant is highly prevalent and is associ