Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yves T Falanga"'
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60640 (2013)
The generation of antigen-specific antibodies and the development of immunological memory require collaboration between B and T cells. T cell-secreted IL-4 is important for B cell survival, isotype switch to IgG1 and IgE, affinity maturation, and the
Externí odkaz:
https://doaj.org/article/6fb5af0431574801abf5aa50479bdc8b
Autor:
Jeffrey A. Bailey, Yasin Kaymaz, Yves T. Falanga, Leslie J. Berg, Ann M. Moormann, Michela Frascoli, Catherine Forconi, John M. Ong’echa
Publikováno v:
JCI Insight. 2
Cellular and humoral constituents of the immune system differ significantly between children and adults, yet very little is known about the impact of early-life pathogen exposure on this immunologic transition. We examined CD4+ and CD8+ T cell subset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef63053337fd29a8fd8c70a6901257e
https://doi.org/10.1172/jci.insight.93814
https://doi.org/10.1172/jci.insight.93814
Autor:
Sandra Odom, John J. Ryan, Suzanne E. Barbour, Daniel H. Conrad, Carole A. Oskeritzian, Yves T. Falanga, Nicholas Pullen, Motunrayo Kolawole, Fred D. Finkelman, Bernice Huang, Natalia S. Chaimowitz, Nicolas Charles, Juan Rivera, Sarah Spiegel, Jason A. Carlyon, Travis Faber, Kevin Dholaria
Publikováno v:
The Journal of Immunology. 188:4360-4368
Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by allergen crosslinking (XL) of FcεRI-bound allergen-specific IgE. However, recent reports es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf54cfa19a86ebca5c2586f7d6fede0
https://doi.org/10.4049/jimmunol.1003223
https://doi.org/10.4049/jimmunol.1003223
Publikováno v:
Genes & Immunity. 11:599-608
The Janus kinase/signal transducer and activator of transcription (JAK–STAT) pathway mediates important responses in immune cells. Activation of any of the four JAK family members leads to phosphorylation of one or more of seven STAT family members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5178451b640e1bf93529834bd86826d
https://doi.org/10.1038/gene.2010.35
https://doi.org/10.1038/gene.2010.35
Autor:
Nitai C. Hait, Sarah Spiegel, Johanna K. Morales, Yves T. Falanga, John J. Ryan, Sheldon Milstien, Carole A. Oskeritzian, Dmitri Kapitonov, Megan M. Price
Publikováno v:
The Journal of Experimental Medicine
Systemic exacerbation of allergic responses, in which mast cells play a critical role, results in life-threatening anaphylactic shock. Sphingosine-1–phosphate (S1P), a ligand for a family of G protein–coupled receptors, is a new addition to the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da37cb93f1ea1e1e9df65e2d89708d1d
http://europepmc.org/articles/PMC2839150
http://europepmc.org/articles/PMC2839150
Publikováno v:
World Allergy Organization Journal, Vol 2, Iss 10, Pp 224-232 (2009)
The World Allergy Organization Journal
The World Allergy Organization Journal
Mast cells are well known as principle effector cells of type I hypersensitivity responses. Beyond this role in allergic disease, these cells are now appreciated as playing an important role in many inflammatory conditions. This review summarizes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346bffd5bf335e9c2ac7f20d95a983d9
http://www.sciencedirect.com/science/article/pii/S1939455119305538
http://www.sciencedirect.com/science/article/pii/S1939455119305538
Autor:
Yves T. Falanga, Kuzhuvelil B. Harikumar, Sarah Spiegel, Elizabeth Motunrayo Kolawole, Megan M. Price, Carole A. Oskeritzian, Alena P. Chumanevich, Sheldon Milstien, John J. Ryan, Roger A. Sabbadini, Nitai C. Hait, Piper Wedman
Publikováno v:
The Journal of allergy and clinical immunology. 135(4)
Background Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid produced by mast cells (MCs) on cross-linking of their high-affinity receptors for IgE by antigen that can amplify MC responses by binding to its S1P receptors. An acute MC-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c979f2f031a41ff00db48c6d025bb4f
https://pubmed.ncbi.nlm.nih.gov/25512083
https://pubmed.ncbi.nlm.nih.gov/25512083
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Frontiers in Immunology
Frontiers in Immunology
Mast cells are central players in immune surveillance and activation, positioned at the host-environment interface. Understanding the signaling events controlling mast cell function, especially those that maintain host homeostasis, is an important an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8603409dd2f36958f2c6bc6f9a7d02a
Autor:
Kazuya Mizuno, Yves T. Falanga, Petr Dráber, Bridget S. Wilson, Nicholas Pullen, Emily A. Harry, Zhengqi Wang, Michele C. Khurana, Tenchee Lama Tamang, Ryo Suzuki, John J. Ryan, Kevin D. Bunting, Brian O. Barnstein
Publikováno v:
The Journal of biological chemistry. 287(3)
Previous studies indicate that STAT5 expression is required for mast cell development, survival, and IgE-mediated function. STAT5 tyrosine phosphorylation is swiftly and transiently induced by activation of the high affinity IgE receptor, FcϵRI. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ab666f04f3b54f6df8371b47c7fb6c
https://pubmed.ncbi.nlm.nih.gov/22130676
https://pubmed.ncbi.nlm.nih.gov/22130676
Autor:
Daniel H. Conrad, Yves T. Falanga, Sarah Spiegel, Carole A. Oskeritzian, John J. Ryan, Jeremy C. Allegood, Kuzhuvelil B. Harikumar, Sheldon Milstien, Megan M. Price, Sergio E. Alvarez
Publikováno v:
The Journal of allergy and clinical immunology. 131(2)
Background: Sphingosine-1-phosphate (S1P), which is produced by 2 sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2, has been implicated in IgE-mediated mast cell responses. However, studies of allergic inflammation in isotype-specific SphK knock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22d7dcfb82bb8efc3f2cc54bace7179
https://pubmed.ncbi.nlm.nih.gov/22939756
https://pubmed.ncbi.nlm.nih.gov/22939756