Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Yves T, Wang"'
Autor:
Pei-Lun Chu, Joseph C. Gigliotti, Sylvia Cechova, Gabor Bodonyi-Kovacs, Yves T. Wang, Luojing Chen, Sylvia Wassertheil-Smoller, Jianwen Cai, Brant E. Isakson, Nora Franceschini, Thu H. Le
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F30-F42
The findings of our study are significant in several ways: 1) loss of an amino acid chaperone in the proximal tubule is sufficient to cause hypertension, 2) the results in global and proximal tubule-specific collectrin knockout mice support the notio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8916a7e38d01f9f03b405373b05af6d2
https://doi.org/10.1152/ajprenal.00176.2022
https://doi.org/10.1152/ajprenal.00176.2022
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2617-2628 (2018)
Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II. Herein, using stable-isotope-res
Externí odkaz:
https://doaj.org/article/a1dc1048aabd47c6a5b6e7a8209630d9
Autor:
Emilie H. Lothet, Kendrick M. Shaw, Hui Lu, Junqi Zhuo, Yves T. Wang, Shi Gu, Donna B. Stolz, E. Duco Jansen, Charles C. Horn, Hillel J. Chiel, Michael W. Jenkins
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the
Externí odkaz:
https://doaj.org/article/ef485175ef8c4bb4ada77f91c156fa83
Autor:
Pei-Lun, Chu, Joseph C, Gigliotti, Sylvia, Cechova, Gabor, Bodonyi-Kovacs, Yves T, Wang, Luojing, Chen, Sylvia, Wassertheil-Smoller, Jianwen, Cai, Brant E, Isakson, Nora, Franceschini, Thu H, Le
Publikováno v:
American journal of physiology. Renal physiology. 324(1)
Collectrin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::018f2d8ddd6d9d2fbf9b241e033a6e4f
https://pubmed.ncbi.nlm.nih.gov/36264884
https://pubmed.ncbi.nlm.nih.gov/36264884
Publikováno v:
Hypertension. 79
Hypertension (HTN) is highly prevalent and is a significant risk factor for CVD. Excessive vasoconstriction contributes to HTN. Recently, p90 ribosomal S6 kinase, isoform 2 (RSK2) signaling has been shown to play a significant role in the regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf78674e43b812fa3ae6677ac120356
https://doi.org/10.1161/hyp.79.suppl_1.p333
https://doi.org/10.1161/hyp.79.suppl_1.p333
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183761 (2017)
Human cardiac myocytes derived from pluripotent stem cells (hCM) have invigorated interest in genetic disease mechanisms and cardiac safety testing; however, the technology to fully assess electrophysiological function in an assay that is amenable to
Externí odkaz:
https://doaj.org/article/83c0dfd6e6bb4b7fa5c740ba3b10a862
Publikováno v:
Hypertension. 78
The glutathione S-transferase ( Gst ) gene family encodes antioxidant enzymes. In humans, a common null allele deletion variant of GST μ-1 ( GSTM1 ) is highly prevalent across populations and is associated with increased risk and progression of vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273414a68e48b2952e9fbef70cd593d5
https://doi.org/10.1161/hyp.78.suppl_1.mp58
https://doi.org/10.1161/hyp.78.suppl_1.mp58
Publikováno v:
Hypertension. 78
Nuclear Factor of Activated T Cells 1 (NFATC1) plays a role in the immune response and has been shown to be required for cardiac development. A recent trans-ethnic meta-analysis of genome-wide association studies (GWAS) found the NFATC1 gene in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c03447d564f33bef2a8bfbff957c94
https://doi.org/10.1161/hyp.78.suppl_1.mp33
https://doi.org/10.1161/hyp.78.suppl_1.mp33
Autor:
Guang Yang, Yves T. Wang, Bing Yu, Gabor Bodonyi-Kovacs, Phillip Ruiz, Janet V. Cross, Anna Köttgen, Eric Boerwinkle, Megan L. Grove, Nhu T. Nguyen, Adrienne Tin, Sylvia Cechova, Fang Chan, Josef Coresh, Shirin Pourafshar, Casey M. Rebholz, Sun-Sang J. Sung, Joseph C. Gigliotti, Robert B. Scharpf, Morgan E. Grams, Thu H. Le
Publikováno v:
J Am Soc Nephrol
Background GSTM1 encodes glutathione S-transferase μ-1 (GSTM1), which belongs to a superfamily of phase 2 antioxidant enzymes. The highly prevalent GSTM1 deletion variant is associated with kidney disease progression in human cohorts: the African Am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c434a3f3238a7aadabf65ce56caaefac
https://doi.org/10.1681/asn.2019050449
https://doi.org/10.1681/asn.2019050449
Autor:
Matthew N. McCall, Keith Nehrke, Yunki Lim, Yves T. Wang, Cole M. Haynes, Paul S. Brookes, Kai-Ting Huang
Publikováno v:
Am J Physiol Heart Circ Physiol
The mitochondrial unfolded protein response (UPRmt) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPRmt activation upregulates chaperones, proteases, antioxidants, and glycolysis at the gene level to restore proteostas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954515ef3d3380432917ed7a30ef2410
https://doi.org/10.1152/ajpheart.00244.2019
https://doi.org/10.1152/ajpheart.00244.2019