Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yves Ruff"'
Autor:
Xavier Pelle, Pierre Nimsgern, Pascale Fille, Yves Ruff, Frederic Berst, Maxim Ratnikov, Roberto Martinez
Publikováno v:
ACS Combinatorial Science. 22:120-128
The use of DNA-encoded libraries has emerged as a powerful hit generation technology. Combining the power of combinatorial chemistry to enumerate large compound collections with the efficiency of affinity selection in pools, the methodology makes it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d85bb9dafd6f294d55d76f8a65e945
https://doi.org/10.1021/acscombsci.9b00164
https://doi.org/10.1021/acscombsci.9b00164
Publikováno v:
ACS Biomater Sci Eng
The development of tumor-targeted nanoscale carriers for the delivery of cancer therapeutics offers the ability to increase efficacy while limiting off-target toxicity. In this work we focused on targeting death receptor 5 (DR5), which is highly expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efab7ecff5a74887b49e0c0bac04aeaa
https://doi.org/10.1021/acsbiomaterials.9b01259
https://doi.org/10.1021/acsbiomaterials.9b01259
Autor:
Frederic Berst, Yves Ruff
Publikováno v:
MedChemComm. 9:1188-1193
Herein, we describe the development of copper-catalyzed cross-coupling of DNA-conjugated aryl iodides with aliphatic amines. This protocol leverages a novel ligand, 2-((2,6-dimethoxyphenyl)amino)-2-oxoacetic acid, to effect the transformation in aque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59873ab2abc86dc512d4db1aa5d3ef10
https://doi.org/10.1039/c8md00185e
https://doi.org/10.1039/c8md00185e
Herein, we describe the development of a practical catch-and release methodology utilizing a cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c45a82d3fb177b72b19fce7bd034a6
https://doi.org/10.26434/chemrxiv.8174864.v1
https://doi.org/10.26434/chemrxiv.8174864.v1
Publikováno v:
Journal of the American Chemical Society. 136:6333-6339
The broad interest of using reversible covalent bonds in chemistry, in particular at its interfaces with biology and materials science, has been recently established through numerous examples in the literature. However, the challenging exchange of pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05809e376da808f0f8d57a8fd481a996
https://doi.org/10.1021/ja4129845
https://doi.org/10.1021/ja4129845
Publikováno v:
New J. Chem.. 38:3336-3349
Because of their recent interest towards dynamic combinatorial systems, chemists have to challenge their capacity to analyse complex mixtures of components exchanging their molecular fragments over time. Here we present, by a selection of practical e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86fd79eb0863878b0dd3ab4f64c507b3
https://doi.org/10.1039/c4nj00304g
https://doi.org/10.1039/c4nj00304g
Publikováno v:
Journal of the American Chemical Society. 135:6211-6219
We report here the preparation of filamentous virus-like particles by the encapsulation of a linear or circular double-stranded DNA template with preassembled mushroom-shaped nanostructures having a positively charged domain. These nanostructures mim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571079efe8567a1bdf377cb08f6e82e8
https://doi.org/10.1021/ja4008003
https://doi.org/10.1021/ja4008003
Autor:
Yves Ruff, Jean-Marie Lehn
Publikováno v:
Angewandte Chemie (English Edition)
Angewandte Chemie (English Edition), John Wiley & Sons, 2008, pp.3556
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, pp.3556. ⟨10.1002/anie.200703490⟩
Angewandte Chemie (English Edition), John Wiley & Sons, 2008, pp.3556
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, pp.3556. ⟨10.1002/anie.200703490⟩
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839c3b4a1b0e5f0674ad5947359db695
https://doi.org/10.1002/ange.200703490
https://doi.org/10.1002/ange.200703490
Autor:
Bernd Kuhn, Hans Peter Wessel, Jens-Uwe Peters, Patrizio Mattei, Robert Narquizian, Pierre C. Wyss, Luca Gobbi, Daniel Hunziker, Thomas Lübbers, Bernd Michael Löffler, Markus Bohringer, Yves Ruff, Michael Hennig
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2966-2970
In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd6c90da848493eb8e57076b093f2bc
https://doi.org/10.1016/j.bmcl.2007.03.072
https://doi.org/10.1016/j.bmcl.2007.03.072
Publikováno v:
ChemInform. 45
Because of their recent interest towards dynamic combinatorial systems, chemists have to challenge their capacity to analyse complex mixtures of components exchanging their molecular fragments over time. Here we present, by a selection of practical e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3dee84525b7c51d3b112a82f44bd90d
https://doi.org/10.1002/chin.201437263
https://doi.org/10.1002/chin.201437263