Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yves R. Juste"'
Autor:
Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R. Juste, Susanne Wegmann, Bindi Patel, Zapporah T. Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G. Lopez, Celeste M. Karch, Alison M. Goate, Jason E. Gestwicki, Bradley T. Hyman, Li Gan, Ana Maria Cuervo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathwa
Externí odkaz:
https://doaj.org/article/212054e33af24b80a55cb5e3dd710b36
Autor:
Yves R. Juste, Susmita Kaushik, Mathieu Bourdenx, Ranee Aflakpui, Sanmay Bandyopadhyay, Fernando Garcia, Antonio Diaz, Kristen Lindenau, Vincent Tu, Gregory J. Krause, Maryam Jafari, Rajat Singh, Javier Muñoz, Fernando Macian, Ana Maria Cuervo
Publikováno v:
Nature Cell Biology. 23:1255-1270
Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential
Autor:
Susmita Kaushik, Yves R. Juste, Kristen Lindenau, Shuxian Dong, Adrián Macho-González, Olaya Santiago-Fernández, Mericka McCabe, Rajat Singh, Evripidis Gavathiotis, Ana Maria Cuervo
Publikováno v:
Science Advances. 8
Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes.
Autor:
Peter Dongmin Sohn, Bindi Patel, Yves R. Juste, Chao Wang, Alison Goate, Bradley T. Hyman, Mathieu Bourdenx, Celeste M. Karch, Jose A. Rodriguez-Navarro, Susanne Wegmann, Antonio Diaz, Enrique Luengo, Jason E. Gestwicki, Li Gan, Hao Shao, Zapporah T. Young, Ana Maria Cuervo, Manuela G. López, Szu Yu Kuo, Xu Chen, Benjamin Caballero
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications 12(1), 2238 (2021). doi:10.1038/s41467-021-22501-9
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications 12(1), 2238 (2021). doi:10.1038/s41467-021-22501-9
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early pathological event in neurodegeneration. In this work, we find that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f11b5fa69254fffbb0ac8766e23868
https://escholarship.org/uc/item/08b6k9xc
https://escholarship.org/uc/item/08b6k9xc
Autor:
Yves R. Juste, Eugene V. Mosharov, Qisheng Xin, Aurora Scrivo, Enrique Luengo, Nevan J. Krogan, Jose A. Rodriguez-Navarro, Ludovic Collin, Antonio Diaz, Mathieu Bourdenx, Evripidis Gavathiotis, Erica Stevenson, Fiona Grueninger, Nadia J. Storm, Ana Maria Cuervo, David Sulzer, Adrián Martín-Segura, Cristina C. Clement, Se Joon Choi, Danielle L. Swaney, Laura Santambrogio, Inmaculada Tasset, Susmita Kaushik
Publikováno v:
Cell
Components of the proteostasis network malfunction in aging, and reduced protein quality control in neurons has been proposed to promote neurodegeneration. Here, we investigate the role of chaperone-mediated autophagy (CMA), a selective autophagy sho
Autor:
Yves R. Juste, Ana Maria Cuervo
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988723
Chaperone-mediated autophagy (CMA) is a selective type of autophagy whereby a specific subset of intracellular proteins is targeted to the lysosome for degradation. These proteins are identified by a chaperone that targets them to lysosomes. There, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67118c2cc2226f3098bb3546aea2575b
https://doi.org/10.1007/978-1-4939-8873-0_47
https://doi.org/10.1007/978-1-4939-8873-0_47
Autor:
Barbara Stiller, Eckhard Mandelkow, Eva Maria Mandelkow, Benjamin Caballero, Ana Maria Cuervo, Yves R. Juste, Inmaculada Tasset, Antonio Diaz, Yipeng Wang
Publikováno v:
Aging cell 17(1), e12692 (2017). doi:10.1111/acel.12692
Aging Cell
Aging Cell
Summary Loss of neuronal proteostasis, a common feature of the aging brain, is accelerated in neurodegenerative disorders, including different types of tauopathies. Aberrant turnover of tau, a microtubule‐stabilizing protein, contributes to its acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b95a92cdc02add0f08c195e65bd176