Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yves Poitevin"'
Autor:
Anja Seckinger, Sara Majocchi, Valéry Moine, Lise Nouveau, Hoang Ngoc, Bruno Daubeuf, Ulla Ravn, Nicolas Pleche, Sebastien Calloud, Lucile Broyer, Laura Cons, Adeline Lesnier, Laurence Chatel, Anne Papaioannou, Susana Salgado-Pires, Sebastian Krämer, Ines Gockel, Florian Lordick, Krzysztof Masternak, Yves Poitevin, Giovanni Magistrelli, Pauline Malinge, Limin Shang, Sonja Kallendrusch, Klaus Strein, Dirk Hose
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-23 (2023)
Abstract Background T-cell retargeting to eliminate CEACAM5-expressing cancer cells via CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly due to insufficient T-cell activation, dose-limiting toxicities, and for
Externí odkaz:
https://doaj.org/article/30b29a2c343143119fd06970474edb47
Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody
Autor:
Anja Seckinger, Vanessa Buatois, Valéry Moine, Bruno Daubeuf, Françoise Richard, Laurence Chatel, Alizée Viandier, Nicolas Bosson, Emeline Rousset, Krzysztof Masternak, Susana Salgado-Pires, Claudia Batista, Christelle Mougin, Flora Juan-Bégeot, Yves Poitevin, Dirk Hose
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundBlocking the CD47 “don’t eat me”-signal on tumor cells with monoclonal antibodies or fusion proteins has shown limited clinical activity in hematologic malignancies and solid tumors thus far. Main side effects are associated with non-
Externí odkaz:
https://doaj.org/article/54cec0396f744440a1e37f2a5e4704e8
Autor:
Walter Ferlin, Stéphanie Hugues, Xavier Chauchet, Elise Pernarrieta, Nicolas Bosson, Sébastien Calloud, Louis Hellequin, Margaux Legrand, Alizée Viandier, Françoise Richard, Laura Cons, Pauline Malinge, Tereza Bautzova, Jérémie Bourguignon, Guillemette Pontini, Mengzhu Sun, Ulla Ravn, Valéry Moine, Yves Poitevin, Nicolas Fischer, Limin Shang, Krzysztof Masternak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/fd883ac37182497abd025cc9848e0fb7
Autor:
Giovanni Magistrelli, Guillemette Pontini, Yves Poitevin, Pauline Malinge, Jérémie Bourguignon, Florence Gauye, Elise Fleury, Nicolas Plèche, Lydia Galissaires, Nicolas Fischer
Publikováno v:
Antibodies, Vol 7, Iss 3, p 29 (2018)
Bispecific antibodies (bsAbs) are often composed of several polypeptide chains that have to be expressed adequately to enable optimal assembly and yield of the bsAb. κλ bodies are a bispecific format with a native IgG structure, composed of two dif
Externí odkaz:
https://doaj.org/article/3190ff1b9542462b83d6255b1fa429d0
Autor:
Anja Seckinger, Vanessa Buatois, Valéry Moine, Lise Nouveau, Bruno Daubeuf, Sara Majocchi, Ulla Ravn, Nicolas Bosson, Krzysztof Masternak, Yves Poitevin, Giovanni Magistrelli, Pauline Malinge, Limin Shang, Nicolas Fischer, Klaus Strein, Walter Ferlin, Dirk Hose
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Xavier Chauchet, Sebastien Calloud, Margaux Legrand, Laura Cons, Laurence Chatel, Adeline Lesnier, Nicolas Bosson, Pauline Lloveras, Pauline Malinge, Ulla Ravn, Valery Moine, Bruno Daubeuf, Yves Poitevin, Giovanni Magistrelli, Susana Salgado-Pires, Dmitry Shchelokov, Oleg Demin, Limin Shang, Krzysztof Masternak, Walter Ferlin
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Anja Seckinger, Lise Nouveau, Sara Majocchi, Valéry Moine, Vanessa Buatois, Bruno Daubeuf, Franck Gueneau, Ulla Ravn, Krzysztof Masternak, Yves Poitevin, Emeline Rousset, Giovanni Magistrelli, Pauline Malinge, Limin Shang, Nicolas Fischer, Klaus Strein, Walter Ferlin, Dirk Hose
Publikováno v:
Cancer Research. 83:5100-5100
Background: The CEAxCD3 bispecific antibody (bsAb) NILK-2301 couples CEA (CEACAM5) on cancer cells and CD3 on T-cells inducing T-cell activation (signal 1) and tumor cell killing (TDCC). T-cell activation can be boosted by CEA-targeted CD28-costimula
Autor:
Xavier Chauchet, Sebastien Calloud, Pauline LLoveras, Nicolas Bosson, Margaux Legrand, Laurence Chatel, Laura Cons, Adeline Lesnier, Pauline Malinge, Guillemette Pontini, Christophe Guillamo, Dmitry Shchelokov, Oleg Demin, Ulla Ravn, Valéry Moine, Bruno Daubeuf, Giovanni Magistrelli, Yves Poitevin, Susana Salgado-Pires, Limin Shang, Nicolas Fischer, Walter Ferlin, Krzysztof Masternak
Publikováno v:
Cancer Research. 83:2951-2951
To enhance efficacy of anti-PD-1/PD-L1 antibodies, many combinations with various therapeutic agents are being investigated. Blocking the CD47/SIRPα myeloid checkpoint with monoclonal antibodies (mAbs) or decoy receptors is emerging as an effective
Autor:
Xavier Chauchet, Nicolas Bosson, Margaux Legrand, Laura Cons, Sébastien Calloud, Alizée Viandier, Françoise Richard, Pauline Malinge, Tereza Bautzova, Jérémie Bourguignon, Guillemette Pontini, Elise Penarrieta, Mengzhu Sun, Ulla Ravn, Valéry Moine, Giovanni Magistrelli, Yves Poitevin, Stéphanie Hugues, Limin Shang, Walter Ferlin, Krzysztof Masternak
Publikováno v:
Cancer Research. 82:3429-3429
PD-1/PD-L1 blockade has improved survival across many types of cancer, but only in a minority of patients. Co-targeting PD-1/PD-L1 and the CD47/SIRPα myeloid checkpoint with monoclonal antibody (mAb) combinations showed increased antitumor responses
Autor:
Xavier Chauchet, Sébastien Calloud, Margaux Legrand, Laura Cons, Laurence Chatel, Pauline Lloveras, Coline Burnet-Merlin, Louis Hellequin, Nicolas Bosson, Pauline Malinge, Nicolas Pleche, Jérémie Bourguignon, Guillemette Pontini, Christophe Guillamo, Ulla Ravn, Valéry Moine, Bruno Daubeuf, Yves Poitevin, Giovanni Magistrelli, Limin Shang, Walter Ferlin, Krzysztof Masternak
Publikováno v:
Cancer Research. 82:3428-3428
Blocking the CD47/SIRPα checkpoint has recently emerged as an effective approach to mobilize the myeloid cell compartment and to improve antitumor responses in the clinic. Preclinical models have demonstrated the synergistic benefit of combined CD47