A Role for the V0 Sector of the V-ATPase in Neuroexocytosis: Exogenous V0d Blocks Complexin and SNARE Interactions with V0c

Autor: Christian Lévêque, Yves Maulet, Qili Wang, Marion Rame, Léa Rodriguez, Sumiko Mochida, Marion Sangiardi, Fahamoe Youssouf, Cécile Iborra, Michael Seagar, Nicolas Vitale, Oussama El Far

Publikováno v: Cells, Vol 12, Iss 5, p 750 (2023)

V-ATPase is an important factor in synaptic vesicle acidification and is implicated in synaptic transmission. Rotation in the extra-membranous V1 sector drives proton transfer through the membrane-embedded multi-subunit V0 sector of the V-ATPase. Int

Externí odkaz: https://doaj.org/article/59f893d975e14efca870c5732bb32957

Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1

Autor: Jorge Ramirez-Franco, Kévin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian Lévêque, Claire Debarnot, Pascale Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh R Irani, Oussama El Far

Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cellular and su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46b7a577bd302c4ec0743f8baca25c26
https://doi.org/10.1101/2022.03.29.486232

Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B

Autor: Kévin Debreux, Géraldine Ferracci, Marion Sangiardi, Richard Desplantes, Jacques Fantini, Christian Lévêque, Marie-Pierre Blanchard, Fahamoe Youssouf, Cécile Iborra, Oussama El Far, Jorge Ramírez-Franco, Yves Maulet, Alessandra Flores, Michel R. Popoff, Florian Wernert, Michael Seagar

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (36), pp.18098-18108. ⟨10.1073/PNAS.1908051116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (36), pp.18098-18108. ⟨10.1073/PNAS.1908051116⟩

International audience; Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor components: a polysialoganglioside, predominantly GT1b, and synaptotagmin 1/2. It is widely thought that BoNT/B initially binds to GT1b t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ece8a080cc84fd202aa04b00b7394c
https://www.hal.inserm.fr/inserm-02274412/document

LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels

Autor: Léa Rodriguez, Fabrice Usseglio, Michaël Russier, Morgane Boillot, Fahamoe Youssouf, Norah Boumedine-Guignon, Mickaël Zbili, Christine Formisano-Tréziny, Michael Seagar, María J. Benítez, Marion Sangiardi, Laure Fronzaroli-Molinieres, Stéphanie Baulac, Olivier Caillard, Juan José Garrido, Yves Maulet, Marina De San Feliciano, Dominique Debanne, Oussama El Far

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (29), pp.7719-7724. ⟨10.1073/pnas.1618656114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (29), pp.7719-7724. ⟨10.1073/pnas.1618656114⟩
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Autosomal dominant epilepsy with auditory features results from mutations in leucine-rich glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons. Animal models of LGI1 depletion display spontaneous seizures, ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f623ed8dbbc0511470554df8022dc0f5
https://www.hal.inserm.fr/inserm-01708767

Calcium-dependent translocation of synaptotagmin to the plasma membrane in the dendrites of developing neurones

Autor: Yannick Schwab, Isabelle Marty, Sylvette Chasserot-Golaz, Jérôme Mouton, Yves Maulet, Emmanuel Jover

Publikováno v: Molecular Brain Research. 96:1-13

In neurones, the morphological complexity of the dendritic tree requires regulated growth and the appropriate targeting of membrane components. Accurate delivery of specific supplies depends on the translocation and fusion of transport vesicles. Vesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257925bf3e3b41a461ad40836bd8e1ec
https://doi.org/10.1016/s0169-328x(01)00244-3