Estrogen-related receptor alpha modulates lactate dehydrogenase activity in thyroid tumors.

Autor: Delphine Mirebeau-Prunier, Soazig Le Pennec, Caroline Jacques, Jean-Fred Fontaine, Naig Gueguen, Nathalie Boutet-Bouzamondo, Audrey Donnart, Yves Malthièry, Frédérique Savagner

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58683 (2013)

Metabolic modifications of tumor cells are hallmarks of cancer. They exhibit an altered metabolism that allows them to sustain higher proliferation rates in hostile environment outside the cell. In thyroid tumors, the expression of the estrogen-relat

Externí odkaz: https://doaj.org/article/53a2b26cfc1a405c842e10c235e3de98

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

Autor: Yves Malthièry, Sébastien Faure, Ramaroson Andriantsitohaina, Emilie Lauret, Nicolas Clere

Publikováno v: Angiogenesis
Angiogenesis, Springer Verlag, 2012, 15 (4), pp.745-760. ⟨10.1007/s10456-012-9288-7⟩

International audience; Epidemiological studies report that exposure to pesticides like chlordecone and lindane increases risk of cancer. They may act as endocrine disruptors via the activation of estrogen receptor α (ERα). Carcinogenesis involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f637158d024e026248704a9ee635bc5
https://doi.org/10.1007/s10456-012-9288-7

Dynamic regulation of mitochondrial network and oxidative functions during 3T3-L1 fat cell differentiation

Autor: Mireille Weitheimer, Annie Durand, Mélissa Flamment, Lucie Duluc, Jennifer Rieusset, Mélanie Priou, Gilles Simard, Yves Malthièry, Pierre-Henri Ducluzeau, Raffaela Soleti, Ramaroson Andriantsitohaina, Fransceco Iacobazi

Publikováno v: Journal of Physiology and Biochemistry
Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2011, 67 (3), pp.285-296. ⟨10.1007/s13105-011-0074-6⟩

International audience; Mitochondria have been shown to be impaired in insulin resistance-related diseases but have not been extensively studied during the first steps of adipose cell development. This study was designed to determine the sequence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6f84121996d08e07198c84c0a6f6e4
https://doi.org/10.1007/s13105-011-0074-6

Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques

Autor: Elisabeth Mathieu, Pascal Reynier, Yves Malthièry, Valérie Moal, Yves Gallois

Publikováno v: Clinica Chimica Acta. 386:12-19

Background Low levels of serum testosterone, as typically found in women and children, cannot be measured reliably by immunoassays. Our aim was to develop a sensitive assay to quantitate low serum testosterone concentrations using liquid chromatograp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2acc600528cf332b93c9f9da422e842
https://doi.org/10.1016/j.cca.2007.07.013

Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A disease

Autor: Arnaud Chevrollier, Marc Ferré, Marie-Anne Pou de Crescenzo, Pascal Reynier, Dominique Loiseau, Naïg Gueguen, Agnès Guichet, Yves Malthièry, Marie-Claire Malinge, Dominique Bonneau, Guillaume Nicolas, Patrizia Amati-Bonneau, Christophe Verny, Virginie Guillet

Publikováno v: Annals of Neurology. 61:315-323

Objective Mutations of the mitofusin 2 gene (MFN2) may account for at least a third of the cases of Charcot–Marie–Tooth disease type 2 (CMT2). This study investigates mitochondrial cellular bioenergetics in MFN2-related CMT2A. Methods Mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1214cc538d0ddbf6660c3137287354
https://doi.org/10.1002/ana.21086