Zobrazeno 1 - 10
of 2 008
pro vyhledávání: '"Yves L"'
Autor:
Michal Nemergut, Daniel Pluskal, Jana Horackova, Tereza Sustrova, Jan Tulis, Tomas Barta, Racha Baatallah, Glwadys Gagnot, Veronika Novakova, Marika Majerova, Karolina Sedlackova, Sérgio M. Marques, Martin Toul, Jiri Damborsky, Zbynek Prokop, David Bednar, Yves L. Janin, Martin Marek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational techniques are combined, revealing that imidazopyrazinone luciferins bind to an
Externí odkaz:
https://doaj.org/article/02510bf81fd243d0bfed12a6fdc366d5
Autor:
Yves L. Janin
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1355-1378 (2022)
This perspective is an attempt to document the problems that medicinal chemists are facing in drug discovery. It is also trying to identify relevant/possible, research areas in which academics can have an impact and should thus be the subject of gran
Externí odkaz:
https://doaj.org/article/a1033dcbdd2443598749efea074ba5dc
Autor:
Pierre Legrand, Yves L. Janin
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 935-943 (2022)
In 1949, Reuben G. Jones disclosed an original synthesis of 2-hydroxypyrazines involving a double condensation between 1,2-dicarbonyls and α-aminoamides upon treatment with sodium hydroxide at low temperature. This discovery turned out to be of impo
Externí odkaz:
https://doaj.org/article/2d3b5a6edb3540eb8540f5d5975bd11a
Publikováno v:
BBA Advances, Vol 3, Iss , Pp 100068- (2023)
Gaussia luciferase (GLuc 18.2kDa; 168 residues) is a marine copepod luciferase that emits a bright blue light when oxidizing coelenterazine (CTZ). It is a helical protein where two homologous sequential repeats form two anti-parallel bundles, each ma
Externí odkaz:
https://doaj.org/article/bc1a572b9c3443de8f65a15580671118
Autor:
Tahm Spitznagel, Laurenz S. Matter, Yves L. Kaufmann, Jakob Nilsson, Seraina von Moos, Thomas Schachtner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundIndication biopsies for deterioration of kidney allograft function often require follow-up biopsies to assess treatment response or lack of improvement. Immune-mediated injury, namely borderline rejection (BLR), T-cell mediated rejection (T
Externí odkaz:
https://doaj.org/article/1014f8d7fb694b3cb9dc1481efa85d3b
Autor:
Aiman H. Alnahwi, Samia Ait-Mohand, Véronique Dumulon-Perreault, Yves L. Dory, Brigitte Guérin
Publikováno v:
ACS Omega, Vol 5, Iss 19, Pp 10731-10739 (2020)
Externí odkaz:
https://doaj.org/article/1ed2359947ed4611adce177b6c164c2d
Publikováno v:
Ingenius: Revista de Ciencia y Tecnología, Iss 27 (2021)
This article describes the methodology used to train and test a Deep Neural Network (DNN) with Photoplethysmography (PPG) data performing a regression task to estimate the Respiratory Rate (RR). The DNN architecture is based on a model used to infer
Externí odkaz:
https://doaj.org/article/72d23290a2524302bab3bed4e9815588
Autor:
Henk-Willem Veltkamp, Yves L. Janssens, Meint J. de Boer, Yiyuan Zhao, Remco J. Wiegerink, Niels R. Tas, Joost C. Lötters
Publikováno v:
Micromachines, Vol 13, Iss 11, p 1908 (2022)
In micro-machined micro-electromechanical systems (MEMS), refilled high-aspect-ratio trench structures are used for different applications. However, these trenches often show keyholes, which have an impact on the performance of the devices. In this p
Externí odkaz:
https://doaj.org/article/0696249c50ab453eaba5c142d025a0dd
Autor:
Soon Gang Choi, Julien Olivet, Patricia Cassonnet, Pierre-Olivier Vidalain, Katja Luck, Luke Lambourne, Kerstin Spirohn, Irma Lemmens, Mélanie Dos Santos, Caroline Demeret, Louis Jones, Sudharshan Rangarajan, Wenting Bian, Eloi P. Coutant, Yves L. Janin, Sylvie van der Werf, Philipp Trepte, Erich E. Wanker, Javier De Las Rivas, Jan Tavernier, Jean-Claude Twizere, Tong Hao, David E. Hill, Marc Vidal, Michael A. Calderwood, Yves Jacob
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Comprehensive mapping of binary protein-protein interactions requires to combine several complementary assays. Here, the authors show that complete coverage could be reached with a minimal number of assays as long as they explore various experimental
Externí odkaz:
https://doaj.org/article/2f419fab78844c44ac0e5edf56d0f33d
Autor:
Glwadys Gagnot, Vincent Hervin, Eloi P. Coutant, Sarah Desmons, Racha Baatallah, Victor Monnot, Yves L. Janin
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2846-2852 (2018)
We report here on the use of ethyl nitroacetate as a glycine template to produce α-amino esters. This started with a study of its condensation with various arylacetals to give ethyl 3-aryl-2-nitroacrylates followed by a reduction (NaBH4 and then zin
Externí odkaz:
https://doaj.org/article/12addb5134e5435196e264acdefc2f95