Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Yves Gorin"'
Autor:
Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug‐Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jiang
Publikováno v:
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
Abstract CSF‐1 is a key factor in regulating bone remodeling; osteocytes express CSF‐1 and its receptor. Viable osteocytes are essential for bone remodeling through cell–cell contact and secretion of factors that regulate osteoblasts and osteoc
Externí odkaz:
https://doaj.org/article/6ed315a5d37f442e9dd1522fe1d931e5
Publikováno v:
Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: Glomerular injury is a prominent pathological feature of diabetic kidney disease (DKD). Constitutively active NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species that mediates hyperglycemia-induced mesangial cell (MC) fibro
Externí odkaz:
https://doaj.org/article/4e43f18e7fe64e63b0525663b385cc93
Autor:
Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207285 (2018)
TGFβ promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. Both mTORC1 and mTORC2 are hyperactive in response to TGFβ in various renal diseases. Deptor is a component of mTOR compl
Externí odkaz:
https://doaj.org/article/57b6441881c548a084884a91c4cb14f5
Autor:
John P Fitzgerald, Bijaya Nayak, Karthigayan Shanmugasundaram, William Friedrichs, Sunil Sudarshan, Assaad A Eid, Thomas DeNapoli, Dipen J Parekh, Yves Gorin, Karen Block
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30712 (2012)
Inflammatory cytokines are detected in the plasma of patients with renal cell carcinoma (RCC) and are associated with poor prognosis. However, the primary cell type involved in producing inflammatory cytokines and the biological significance in RCC r
Externí odkaz:
https://doaj.org/article/f966c6a97bb24d6f9387878eec669568
Publikováno v:
University of the Future: Re-Imagining Research and Higher Education.
Introduction: Obesity is a major risk factor for type-2 diabetes predisposing patients to diabetic nephropathy (DN), the leading cause of end-stage renal failure. Glomerular injury is a prominent pathological feature of DN. Sestrin2 (Sesn2) is a stre
Autor:
Yves Gorin, Sumin Gu, Jean X. Jiang, Kathleen Woodruff, Doug-Yoon Lee, Roberto J. Fajardo, Ramaswamy Sharma, Samy L. Habib, Rui Hua, Stephen E. Harris, Sherry L. Werner, Diane Horn
Publikováno v:
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
JBMR Plus
JBMR Plus
CSF‐1 is a key factor in regulating bone remodeling; osteocytes express CSF‐1 and its receptor. Viable osteocytes are essential for bone remodeling through cell–cell contact and secretion of factors that regulate osteoblasts and osteoclasts. In
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 36, Iss, Pp-(2020)
Molecular Metabolism, Vol 36, Iss, Pp-(2020)
Objective Glomerular injury is a prominent pathological feature of diabetic kidney disease (DKD). Constitutively active NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species that mediates hyperglycemia-induced mesangial cell (MC) fibrot
Autor:
Doug Yoon Lee, Goutam Ghosh-Choudhury, Meenalakshmi M. Mariappan, Hak Joo Lee, Hanna E. Abboud, Balakuntalam S. Kasinath, Yves Gorin, Denis Feliers
Publikováno v:
Journal of Biological Chemistry. 292:5665-5675
High-glucose increases NADPH oxidase 4 (NOX4) expression, reactive oxygen species generation, and matrix protein synthesis by inhibiting AMP-activated protein kinase (AMPK) in renal cells. Because hydrogen sulfide (H2S) inhibits high glucose-induced
Autor:
Yves Gorin, Stephanie Eid, Kawthar Braych, Sarah Moodad, Assaad A. Eid, Karen Block, Hanna E. Abboud, Charbel Massaad, Awad Rashid, Ramzi Sabra, Suzan S. Boutary, Ahmed Hamdy
Publikováno v:
Antioxidants & Redox Signaling. 25:703-719
Aim: Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Oxidative stress plays a critical role in hyperglycemia-induced glomerular injury. We explored the hypothesis that mammalian tar
Publikováno v:
The FASEB Journal. 33