Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Yves Genisson"'
Autor:
Coralie Carivenc, Laurent Maveyraud, Claire Blanger, Stéphanie Ballereau, Coralie Roy-Camille, Minh Chau Nguyen, Yves Génisson, Christophe Guilhot, Christian Chalut, Jean-Denis Pedelacq, Lionel Mourey
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Owing to their role in activating enzymes essential for bacterial viability and pathogenicity, phosphopantetheinyl transferases represent novel and attractive drug targets. In this work, we examined the inhibitory effect of the aminido-urea
Externí odkaz:
https://doaj.org/article/f57ec08b40274ca4ab42e00bdf4c4481
Autor:
Pascal Demange, Etienne Joly, Julien Marcoux, Patrick RA Zanon, Dymytrii Listunov, Pauline Rullière, Cécile Barthes, Céline Noirot, Jean-Baptiste Izquierdo, Alexandrine Rozié, Karen Pradines, Romain Hee, Maria Vieira de Brito, Marlène Marcellin, Remy-Felix Serre, Olivier Bouchez, Odile Burlet-Schiltz, Maria Conceição Ferreira Oliveira, Stéphanie Ballereau, Vania Bernardes-Génisson, Valérie Maraval, Patrick Calsou, Stephan M Hacker, Yves Génisson, Remi Chauvin, Sébastien Britton
Publikováno v:
eLife, Vol 11 (2022)
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that t
Externí odkaz:
https://doaj.org/article/793efaee61f44925b2fa3f2f6920aeac
Autor:
Romain Galy, Stéphanie Ballereau, Yves Génisson, Lionel Mourey, Jean-Christophe Plaquevent, Laurent Maveyraud
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1282 (2021)
The mycolic acid biosynthetic pathway represents a promising source of pharmacological targets in the fight against tuberculosis. In Mycobacterium tuberculosis, mycolic acids are subject to specific chemical modifications introduced by a set of eight
Externí odkaz:
https://doaj.org/article/869c4c95e0134e7ba56dcb8fa892eb3e
Publikováno v:
Molecules, Vol 26, Iss 23, p 7223 (2021)
Pompe disease (PD), a lysosomal storage disease, is caused by mutations of the GAA gene, inducing deficiency in the acid alpha-glucosidase (GAA). This enzymatic impairment causes glycogen burden in lysosomes and triggers cell malfunctions, especially
Externí odkaz:
https://doaj.org/article/f7a715ee1d2240fd978baaab1445a5c4
Autor:
V. Bernardes-Genisson, P. Rulliere, M. V. de Brito, P. R. A. Zanon, Julien Marcoux, C. Barthes, M. Marcellin, Odile Burlet-Schiltz, Pascal Demange, Etienne Joly, Patrick Calsou, Sébastien Britton, R. Hee, K. Pradines, Maria da Conceição F. de Oliveira, S. M. Hacker, Olivier Bouchez, Dymytrii Listunov, Céline Noirot, J.-B. Izquierdo, Remi Chauvin, Valérie Maraval, Stéphanie Ballereau, Remy-Felix Serre, Yves Genisson
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd904a0f5f3ad56cf1d37a1e4ddafdb
https://hal.archives-ouvertes.fr/hal-03371218
https://hal.archives-ouvertes.fr/hal-03371218
Publikováno v:
Molecules
Molecules, 2021, 26 (23), pp.7223. ⟨10.3390/molecules26237223⟩
Molecules, Vol 26, Iss 7223, p 7223 (2021)
Molecules, 2021, 26 (23), pp.7223. ⟨10.3390/molecules26237223⟩
Molecules, Vol 26, Iss 7223, p 7223 (2021)
International audience; Pompe disease (PD), a lysosomal storage disease, is caused by mutations of the GAA gene, inducing deficiency in the acid alpha-glucosidase (GAA). This enzymatic impairment causes glycogen burden in lysosomes and triggers cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96a00d5d7866cca51c3ee92d2b692f3
https://hal.science/hal-03758482
https://hal.science/hal-03758482
Publikováno v:
Tetrahedron. 69:7227-7233
A rapid access to jaspine B and its enantiomer ent-jaspine B from a 2,3-aziridino-γ-lactone is reported. This synthesis relies on a one pot regioselective aziridine ring-opening followed by intramolecular cyclization to install the cis-amino–alcoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c07cb83c814aed6f00ce2c01b94e5ebc
https://doi.org/10.1016/j.tet.2013.06.091
https://doi.org/10.1016/j.tet.2013.06.091
Publikováno v:
Current Organic Chemistry. 17:238-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb491453044f591d584126f03656424b
https://doi.org/10.2174/1385272811317030006
https://doi.org/10.2174/1385272811317030006
Publikováno v:
ResearcherID
Sphingolipids, which are complex lipidic components of the cell membranes, lie in a key position to modulate the pathways of trans-membrane signaling and allow the cell to adapt to environmental stresses. In malignancies, reduced production of some s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39dd1c0e223b36c3610c138bbe19d29d
https://doi.org/10.2174/187152012800228634
https://doi.org/10.2174/187152012800228634
Publikováno v:
Current Organic Chemistry. 15:953-986
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b99709b907bebe7517cb26737fdf38
https://doi.org/10.2174/138527211794785127
https://doi.org/10.2174/138527211794785127