Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yves A. Chantigny"'
Autor:
Yves A. Chantigny, Ralph P. Robinson, Kleinman Edward F, Jon Bordner, Patricia A. McNiff, Yuriy A. Abramov, John C. Murray, Michael A. Plotkin, Leonard Buckbinder, Michele L. Millham, Matthew R. Reese, Jean Schaefer
Publikováno v:
Journal of Medicinal Chemistry. 58:2658-2677
A significant improvement in agonist activity of the previously described 2-aryloctahydrophenanthrene-2,3,7-triol series of dissociated glucocorticoid receptor agonists (DAGRs) was achieved by modifying the substitution at C3 from (S)-3-hydroxy to (R
Autor:
Yuriy A. Abramov, John C. Murray, Leonard Buckbinder, Ellen R. Laird, Matthew R. Reese, Kleinman Edward F, Yves A. Chantigny, Matthew David Wessel, E. D. Salter, Sue A. Yocum, Morgan Bradley P, Ralph P. Robinson, Jean Schaefer, Amber I. Haugeto, Jon Bordner, Patricia A. McNiff, Michele L. Millham
Publikováno v:
Journal of Medicinal Chemistry. 52:1731-1743
As exemplified by the lead compound 2, octahydrophenanthrene-2,7-diol analogues exhibit the profile of a pathway-selective or "dissociated" agonist of the glucocorticoid receptor (GR), retaining the potent activity that glucocorticoids have for trans
Autor:
Sylvain Lefebvre, Silvana Leit, Alina Nicolescu, Marielle Fournel, Anthony Panetta, Jeffrey M. Besterman, Jubrail Rahil, Amal Wahhab, Anne-Marie Lemieux, Sukhdev Manku, Christiane R. Maroun, Yves Andre Chantigny, Theresa P. Yan, Robert Deziel, Zuomei Li, David Smil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:688-692
In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/II
Publikováno v:
Canadian Journal of Chemistry. 80:875-884
Transannular DielsAlder (TADA) adducts constitute a collection of rigid structures, whose conformational diversity is rich. It is possible to design such specifically functionalized molecules capable of binding to known biological targets by molecu
Publikováno v:
The Journal of Organic Chemistry. 74:1388-1390
Herein described is an operationally simple procedure for generating benzyl indium species from readily available benzyl bromides and indium metal followed by in situ palladium-catalyzed coupling with aryl halides. The procedure provides diarylmethan
Publikováno v:
ChemInform. 30
A procedure is described for the stereospecific synthesis of 13-membered trienic macrocycles from suitable acyclic bis-allylic chlorides via an intramolecular gem-dialkylation of malononitrile or methyl cyanoacetate.
Publikováno v:
ChemInform. 40
Herein described is an operationally simple procedure for generating benzyl indium species from readily available benzyl bromides and indium metal followed by in situ palladium-catalyzed coupling with aryl halides. The procedure provides diarylmethan
Autor:
Zuomei Li, Alain Ajamian, Sukhdev Manku, Silvana Leit, Marielle Fournel, Martin Allan, Jeffrey M. Besterman, Yves Andre Chantigny, Amal Wahhab, Eric Therrien, Theresa P. Yan, Sylvain Lefebvre, Jubrail Rahil, Andrea J. Petschner, Alina Nicolescu, David Smil, Robert Deziel, Aihua Lu, Samuel Montcalm, Natalie Nguyen
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(2)
The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-se
Publikováno v:
Tetrahedron Letters. 39:7839-7840
A procedure is described for the stereospecific synthesis of 13-membered trienic macrocycles from suitable acyclic bis-allylic chlorides via an intramolecular gem-dialkylation of malononitrile or methyl cyanoacetate.
Autor:
Ralph P. Robinson, Leonard Buckbinder, Amber I. Haugeto, Patricia A. McNiff, Michele L. Millham, Matthew R. Reese, Jean F. Schaefer, Yuriy A. Abramov, Jon Bordner, Yves A. Chantigny, Edward F. Kleinman, Ellen R. Laird, Bradley P. Morgan, John C. Murray, Eben D. Salter, Matthew D. Wessel, Sue A. Yocum
Publikováno v:
Journal of Medicinal Chemistry; Mar2009, Vol. 52 Issue 6, p1731-1743, 13p