Výsledky vyhledávání - "Yves A, DeClerck"

Akademický článek

The capture of extracellular vesicles endogenously released by xenotransplanted tumours induces an inflammatory reaction in the premetastatic niche

Autor: Laurence Blavier, Rie Nakata, Paolo Neviani, Khounish Sharma, Hiroyuki Shimada, Aitor Benedicto, Irina Matei, David Lyden, Yves A. DeClerck

Publikováno v: Journal of Extracellular Vesicles, Vol 12, Iss 5, Pp n/a-n/a (2023)

Abstract The capture of tumour‐derived extracellular vesicles (TEVs) by cells in the tumour microenvironment (TME) contributes to metastasis and notably to the formation of the pre‐metastatic niche (PMN). However, due to the challenges associated

Externí odkaz: https://doaj.org/article/6ec20ddebcdc41519688e2d3bb29de3a

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Akademický článek

Fibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-β/IL-6 pathway in neuroblastoma

Autor: Kevin Louault, Tania Porras, Meng-Hua Lee, Sakunthala Muthugounder, Rebekah J. Kennedy, Laurence Blavier, Emily Sarte, G. Esteban Fernandez, Fusheng Yang, Bruce R. Pawel, Hiroyuki Shimada, Shahab Asgharzadeh, Yves A. DeClerck

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Tumor-associated macrophages (TAM) and cancer-associated fibroblasts (CAF) and their precursor mesenchymal stromal cells (MSC) are often detected together in tumors, but how they cooperate is not well understood. Here, we show that TAM and CAF are th

Externí odkaz: https://doaj.org/article/e3a9711c53f144c9ad2f0492fa1ecbf7

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Data from Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance

Autor: Hua Yu, Yves A. DeClerck, Lucia Borriello, Adar Makovski-Silverstein, Heehyoung Lee, Gregory Cherryholmes, Wenzhao Li, Saul J. Priceman, Veronica Lifshitz

Drug resistance is a major barrier for the development of effective and durable cancer therapies. Overcoming this challenge requires further defining the cellular and molecular mechanisms underlying drug resistance, both acquired and environment-medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c45c7c6b94516b0aed02918814027b5
https://doi.org/10.1158/1535-7163.c.6539556.v1

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Supplemental figure legends from Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance

Autor: Hua Yu, Yves A. DeClerck, Lucia Borriello, Adar Makovski-Silverstein, Heehyoung Lee, Gregory Cherryholmes, Wenzhao Li, Saul J. Priceman, Veronica Lifshitz

Supplemental Figure 1. Bone marrow stromal cells enhance NB resistance to etoposide; Supplemental Figure 2. Overexpression of S1PR1 in CHLA-171 cells activates STAT3 and renders cells resistant to etoposide via JAK2/STAT3 signaling; Supplemental Figu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8925f0e373702942420f8488b5087f
https://doi.org/10.1158/1535-7163.22510248

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Data from Bone Marrow–Derived Mesenchymal Stromal Cells Promote Survival and Drug Resistance in Tumor Cells

Autor: Yves A. DeClerck, Laurence Blavier, Scott A. Bergfeld

Bone marrow mesenchymal stromal cells (BMMSC) have antitumorigenic activities. Here, we hypothesized that circulating BMMSC are incorporated into tumors and protect tumor cells from therapy-induced apoptosis. Adherent cells harvested from murine bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2da49ec5aa3a93b23a342493b5c3de0f
https://doi.org/10.1158/1535-7163.c.6536745.v1

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Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6 from Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance

Autor: Hua Yu, Yves A. DeClerck, Lucia Borriello, Adar Makovski-Silverstein, Heehyoung Lee, Gregory Cherryholmes, Wenzhao Li, Saul J. Priceman, Veronica Lifshitz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7a5f3c0651cac3d7a4326d90fda673
https://doi.org/10.1158/1535-7163.22510251

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Supplementary Figures 1 through 3 from Bone Marrow–Derived Mesenchymal Stromal Cells Promote Survival and Drug Resistance in Tumor Cells

Autor: Yves A. DeClerck, Laurence Blavier, Scott A. Bergfeld

PDF - 74K, Supplemental Figure S1. Expansion of LL/2 tumor cells exposed to BMMSC; Supplemental Figure S2. Cell cycle progression in 4T1 tumor cells exposed to BMMSC; Supplemental Figure S3. Stress-induced apoptosis in LL/2 tumor cells exposed to BMM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a95f9e0499695ba23b359a39ddd6d3f
https://doi.org/10.1158/1535-7163.22501305.v1

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