Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Yves, Durocher"'
Autor:
Tyler M. Renner, Matthew Stuible, Brian Cass, Sylvie Perret, Julie Guimond, Simon Lord-Dufour, Michael J. McCluskie, Yves Durocher, Bassel Akache
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-8 (2024)
Abstract The COVID-19 pandemic has emphasised the importance of vaccines and preparedness against viral threats crossing species barriers. In response, a worldwide vaccination campaign targeting SARS-CoV-2 was implemented, which provides some cross-p
Externí odkaz:
https://doaj.org/article/a8d0af306892431ba70122d09fbd30e1
Autor:
Levi Tamming, Diana Duque, Anh Tran, Casey Lansdell, Grant Frahm, Jianguo Wu, Emily E.F. Fekete, Marybeth Creskey, Sathya N. Thulasi Raman, Emmanuel Laryea, Wanyue Zhang, Annabelle Pfeifle, Caroline Gravel, Andrew Stalker, Anwar M. Hashem, Wangxue Chen, Matthew Stuible, Yves Durocher, David Safronetz, Jingxin Cao, Lisheng Wang, Simon Sauve, Michael Rosu-Myles, Xu Zhang, Michael J.W. Johnston, Xuguang Li
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 33, Iss 1, Pp 101388- (2025)
Externí odkaz:
https://doaj.org/article/e70f10219c4c423f87e16236b52365bb
Autor:
Marzia Martina, Umberto Banderali, Alvaro Yogi, Mehdi Arbabi Ghahroudi, Hong Liu, Traian Sulea, Yves Durocher, Greg Hussack, Henk van Faassen, Balu Chakravarty, Qing Yan Liu, Umar Iqbal, Binbing Ling, Etienne Lessard, Joey Sheff, Anna Robotham, Debbie Callaghan, Maria Moreno, Tanya Comas, Dao Ly, Danica Stanimirovic
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Genetic studies have identified the voltage‐gated sodium channel 1.7 (Nav1.7) as pain target. Due to the ineffectiveness of small molecules and monoclonal antibodies as therapeutics for pain, single‐domain antibodies (VHHs) are developed
Externí odkaz:
https://doaj.org/article/25473da9710e4c68b7eed6b4056350ba
Autor:
Callum M Ives, Linh Nguyen, Carl A Fogarty, Aoife M Harbison, Yves Durocher, John Klassen, Elisa Fadda
Publikováno v:
eLife, Vol 13 (2024)
Glycosylation of the SARS-CoV-2 spike (S) protein represents a key target for viral evolution because it affects both viral evasion and fitness. Successful variations in the glycan shield are difficult to achieve though, as protein glycosylation is a
Externí odkaz:
https://doaj.org/article/0002cdb6517c4b4284c739104f9833f0
Autor:
Matthew Stuible, Joseph D. Schrag, Joey Sheff, Daria Zoubchenok, Simon Lord-Dufour, Brian Cass, Denis L’Abbé, Alex Pelletier, Martin A. Rossotti, Jamshid Tanha, Christian Gervais, Roger Maurice, Majida El Bakkouri, Mauro Acchione, Yves Durocher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimi
Externí odkaz:
https://doaj.org/article/dc399963cdec43a6ac763c16fa63044f
Autor:
Janelle Sauvageau, Izel Koyuturk, Frank St. Michael, Denis Brochu, Marie-France Goneau, Ian Schoenhofen, Sylvie Perret, Alexandra Star, Anna Robotham, Arsalan Haqqani, John Kelly, Michel Gilbert, Yves Durocher
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Glycosylation is a key quality attribute that must be closely monitored for protein therapeutics. Established assays such as HILIC-Fld of released glycans and LC-MS of glycopeptides work well for glycoproteins with a few glycosylation sites
Externí odkaz:
https://doaj.org/article/b6b1904909a242f99f4b91f266f9ce1c
Autor:
Sergio P. Alpuche-Lazcano, Matthew Stuible, Bassel Akache, Anh Tran, John Kelly, Sabahudin Hrapovic, Anna Robotham, Arsalan Haqqani, Alexandra Star, Tyler M. Renner, Julie Blouin, Jean-Sébastien Maltais, Brian Cass, Kai Cui, Jae-Young Cho, Xinyu Wang, Daria Zoubchenok, Renu Dudani, Diana Duque, Michael J. McCluskie, Yves Durocher
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-12 (2023)
Abstract Background As the COVID-19 pandemic continues to evolve, novel vaccines need to be developed that are readily manufacturable and provide clinical efficacy against emerging SARS-CoV-2 variants. Virus-like particles (VLPs) presenting the spike
Externí odkaz:
https://doaj.org/article/e632d3165fd5455aba16eee54c396641
Autor:
Bernarda Pschunder, Lucia Locati, Oriana López, Pablo Martin Aispuro, Eugenia Zurita, Matthew Stuible, Yves Durocher, Daniela Hozbor
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
For several years, we have been committed to exploring the potential of Bordetella pertussis-derived outer membrane vesicles (OMVBp) as a promising third-generation vaccine against the reemerging pertussis disease. The results of our preclinical tria
Externí odkaz:
https://doaj.org/article/b9a1ba9445c54fc48adbf0208d084885
Autor:
Abdelhadi Djaïleb, Megan-Faye Parker, Étienne Lavallée, Matthew Stuible, Yves Durocher, Mathieu Thériault, Kim Santerre, Caroline Gilbert, Denis Boudreau, Mariana Baz, Jean-Francois Masson, Marc-André Langlois, Sylvie Trottier, Daniela Quaglia, Joelle N. Pelletier
Publikováno v:
PLoS ONE, Vol 19, Iss 12 (2024)
Externí odkaz:
https://doaj.org/article/51e81b0615ab48de91aff1a90b94d5fd
Autor:
Seyed Farzad Baniahmad, Romane Oliverio, Ines Obregon-Gomez, Alma Robert, Anne E.G. Lenferink, Elena Pazos, Nick Virgilio, Xavier Banquy, Gregory De Crescenzo, Yves Durocher
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTLong-term delivery is a successful strategy used to reduce the adverse effects of monoclonal antibody (mAb)-based treatments. Macroporous hydrogels and affinity-based strategies have shown promising results in sustained and localized delivery
Externí odkaz:
https://doaj.org/article/71ba275737b74e2f8835f58cc65a74d4