Výsledky vyhledávání - "Yvan Le Huerou"

Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

Autor: Eli M. Wallace, Francis X. Sullivan, Yvan Le Huerou, Stefan D. Gross, Jennifer Garrus, P LouAnn Cable, Richard Woessner, Kurtis D. Davies, Ira von Carlowitz

Publikováno v: Cancer Biology & Therapy. 12:788-796

Inhibition of the checkpoint kinase Chk1, both as a monotherapy and in combination with DNA damaging cytotoxics, is a promising therapeutic approach for the treatment of a wide array of human cancers. However, much remains to be elucidated in regard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0494919b800bb720622467c9bd507a7e
https://doi.org/10.4161/cbt.12.9.17673

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Novel acyl coenzyme A (CoA): Diacylglycerol acyltransferase-1 inhibitors: Synthesis and biological activities of diacylethylenediamine derivatives

Autor: Steve A. Boyd, Shuji Kitamura, Thomas Daniel Aicher, Koki Kato, Yoshihisa Nakada, Turner Timothy M, Scott Alan Pratt, Hiroshi Yamaguchi, Hiroshi Miki, Stephen S. Gonzales, Toshihiro Yamamoto, Yvan Le Huerou

Publikováno v: Bioorganic & Medicinal Chemistry. 18:2785-2795

A series of diacylethylenediamine derivatives were synthesized and evaluated for their inhibitory activity against DGAT-1 and pharmacokinetic profile to discover new small molecule DGAT-1 inhibitors. Among the compounds, N-[2-({[1-phenyl-3-(trifluoro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099c43ff8025bbb995fca867fe4634c4
https://doi.org/10.1016/j.bmc.2010.01.067

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Prodrug thiamine analogs as inhibitors of the enzyme transketolase

Autor: Allen A. Thomas, Todd Romoff, Laura Hayter, Jed Pheneger, Jason De Meese, Patrice Lee, Boyd Steven A, S. Kirk Wright, Christine Lemieux, Gunawardana Indrani W, Steven S. Gonzales, Walter E. DeWolf, Francis X. Sullivan, Yvan Le Huerou, Jie Lin, Gregory K. Poch, May Han, Tomas Kaplan, Solly Weiler

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:505-508

Transketolase, a key enzyme in the pentose phosphate pathway, has been suggested as a target for inhibition in the treatment of cancer. Compound 5a ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c52fc62ae58a00ee42cd9c0ad1223c8
https://doi.org/10.1016/j.bmcl.2007.11.100

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Total Synthesis of (−)-Steganone Utilizing a Samarium(II) Iodide Promoted 8-Endo Ketyl−Olefin Cyclization

Autor: and Magnus Rönn, Lauren G. Monovich, Yvan Le Huerou, Gary A. Molander

Publikováno v: Journal of the American Chemical Society. 122:52-57

A six-step synthesis of (±)-steganone from commercially available 3,4,5-trimethoxybenzyl alcohol features a samarium(II) iodide promoted 8-endo ketyl−olefin coupling to install, in a single transformation, the 8,5 ring system common to the lignan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65afa9365d9deeb6e32e27100fd0a698
https://doi.org/10.1021/ja9930059

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ChemInform Abstract: Synthesis and Cytotoxic Activity of Acetogenin Analogues

Autor: René Grée, Brigitte Renoux, Yvan Le Huerou, Alain Pierre, Stephane Rodier, Jean-Pierre Gesson, Julien Doyon, Pierre Renard

Publikováno v: ChemInform. 31

A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipophilic side chains (alkyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fa3d5705a73b46bab235a5fa44d4c23
https://doi.org/10.1002/chin.200039219

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The microbiological hydroxylation of 3 alpha,5-cycloandrostanes by Cephalosporium aphidicola

Autor: James R. Hanson, Caroline S. Bensasson, Yvan Le Huerou

Publikováno v: Phytochemistry. 52(7)

The microbiological hydroxylation of some 3 alpha,5-cycloandrostanes by the fungus, Cephalosporium aphidicola has been shown to take place at C-2 alpha and C-14 alpha and a 6 beta-alcohol was oxidized to the 6-ketone.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f777e09ef508bb0df7da8c803ccb48bc
https://pubmed.ncbi.nlm.nih.gov/10647215

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Abstract 2939: Chk1 inhibition and Wee1 inhibition combine synergistically to inhibit cellular proliferation

Autor: Yvan Le Huerou, Francis J. Sullivan, Eli M. Wallace, Ira von Carlowitz, Richard Woessner, Stefan Gross, Kurtis D. Davies

Publikováno v: Cancer Research. 71:2939-2939

Inhibition of the checkpoint kinase Chk1, both as a monotherapy and in combination with DNA damaging cytotoxics, is a promising therapeutic strategy for human cancer. However, much remains to be learned in regard to the patient populations that will

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3b827ce4619f3cb56fb94d7ff0f74c1
https://doi.org/10.1158/1538-7445.am2011-2939

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Abstract 3874: Single-agent Chk1 inhibition is anti-proliferative in leukemia cells in vitro and in vivo

Autor: Yvan Le Huerou, Michael J. Humphries, Francis J. Sullivan, Bin Wang, Eli M. Wallace, Jim Blake, Kurtis D. Davies, Mark Joseph Chicarelli, Lyon Michael, Ira von Carlowitz, Gunawardana Indrani W, Stefan Gross, Mohr Peter

Publikováno v: Cancer Research. 70:3874-3874

Chk1 is a serine/threonine kinase that plays important roles in the cellular response to genotoxic stress. For this reason, there is a great deal of interest in using inhibitors of Chk1 to potentiate the effects of DNA-damaging chemotherapeutics. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29a2999b099dc916d7e888297fa2fb4a
https://doi.org/10.1158/1538-7445.am10-3874

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