Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yvan Campos"'
Autor:
Jason A. Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G. Robinson, Yvan Campos, Ashutosh Mishra, Leigh E. Fremuth, Elida Gomero, Huimin Hu, Alessandra d’Azzo
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114117- (2024)
Summary: Endoplasmic reticulum-plasma membrane (ER-PM) junctions mediate Ca2+ flux across neuronal membranes. The properties of these membrane contact sites are defined by their lipid content, but little attention has been given to glycosphingolipids
Externí odkaz:
https://doaj.org/article/82ef0594197640f998e89cdc49f6a710
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Ozz, a member of the SOCS-box family of proteins, is the substrate-binding component of CRL5Ozz, a muscle-specific Cullin-RING ubiquitin ligase complex composed of Elongin B/C, Cullin 5 and Rbx1. CRL5Ozz targets for proteasomal degradation s
Externí odkaz:
https://doaj.org/article/d42e09fbc0154d1aaea9af92878e6e3f
Autor:
Huimin Hu, Rosario Mosca, Elida Gomero, Diantha van de Vlekkert, Yvan Campos, Leigh E. Fremuth, Scott A. Brown, Jason A. Weesner, Ida Annunziata, Alessandra d’Azzo
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 644-658 (2021)
AAV-mediated gene therapy holds promise for the treatment of lysosomal storage diseases (LSDs), some of which are already in clinical trials. Yet, ultra-rare subtypes of LSDs, such as some glycoproteinoses, have lagged. Here, we report on a long-term
Externí odkaz:
https://doaj.org/article/4f4d2859730e48d497c3d91716323069
Autor:
Ida Annunziata, Diantha van de Vlekkert, Elmar Wolf, David Finkelstein, Geoffrey Neale, Eda Machado, Rosario Mosca, Yvan Campos, Heather Tillman, Martine F. Roussel, Jason Andrew Weesner, Leigh Ellen Fremuth, Xiaohui Qiu, Min-Joon Han, Gerard C. Grosveld, Alessandra d’Azzo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by
Externí odkaz:
https://doaj.org/article/642d6aea132848be83c0cf12d1e5c471
Autor:
Min-Joon Han, Ida Annunziata, Jason Weesner, Yvan Campos, Muneeb Salie, Carla O'Reilly, Alessandra d'Azzo
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101836- (2020)
Sialidosis is an autosomal recessive lysosomal storage disease, belonging to the glycoproteinoses. The disease is caused by deficiency of the sialic acid-cleaving enzyme, sialidase 1 or neuraminidase 1 (NEU1). Patients with sialidosis are classified
Externí odkaz:
https://doaj.org/article/54b0b88fc04045d5b1ac57709d78fd3a
Autor:
Yvan Campos, Xiaohui Qiu, Elida Gomero, Randall Wakefield, Linda Horner, Wojciech Brutkowski, Young-Goo Han, David Solecki, Sharon Frase, Antonella Bongiovanni, Alessandra d’Azzo
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Correct assembly of intercellular junctions is required to maintain epithelial polarity and barrier function. Here Campos et al. show that the scaffold protein Alix interacts with F-actin, the Par complex and ZO-1 to ensure the formation and maintena
Externí odkaz:
https://doaj.org/article/c1feeee6b4234f208945cf8f377982ec
Autor:
Rosario Mosca, Diantha van de Vlekkert, Yvan Campos, Leigh E. Fremuth, Jaclyn Cadaoas, Vish Koppaka, Emil Kakkis, Cynthia Tifft, Camilo Toro, Simona Allievi, Cinzia Gellera, Laura Canafoglia, Gepke Visser, Ida Annunziata, Alessandra d’Azzo
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 3, p 695 (2020)
Congenital deficiency of the lysosomal sialidase neuraminidase 1 (NEU1) causes the lysosomal storage disease, sialidosis, characterized by impaired processing/degradation of sialo-glycoproteins and sialo-oligosaccharides, and accumulation of sialylat
Externí odkaz:
https://doaj.org/article/ce7fd4838b01444890527e8e9cf0a0b9
Autor:
Edmar Zanoteli, Naja Vergani, Yvan Campos, Mariz Vainzof, Acary S.B. Oliveira, Alessandra d'Azzo
Publikováno v:
Arquivos de Neuro-Psiquiatria, Vol 67, Iss 1, Pp 102-104 (2009)
Externí odkaz:
https://doaj.org/article/44c996fbae3e4eea90a6bff2736eaedf
Autor:
Yvan Campos, Xiaohui Qiu, Edmar Zanoteli, Simon Moshiach, Naja Vergani, Antonella Bongiovanni, A John Harris, Alessandra d'Azzo
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9866 (2010)
Muscle contractile proteins are expressed as a series of developmental isoforms that are in constant dynamic remodeling during embryogenesis, but how obsolete molecules are recognized and removed is not known. Ozz is a developmentally regulated prote
Externí odkaz:
https://doaj.org/article/819429bbe6fa40818af3ea631a21a59b
Autor:
Xiaohui Qiu, Yvan Campos, Diantha van de Vlekkert, Elida Gomero, Ajay C. Tanwar, Ravi Kalathur, Jason A. Weesner, Antonella Bongiovanni, Jeroen Demmers, Alessandra d’Azzo
Publikováno v:
Journal of Biological Chemistry, 298(10):102425. American Society for Biochemistry and Molecular Biology Inc.
Alix is a ubiquitously expressed scaffold protein that participates in numerous cellular processes related to the remodeling/repair of membranes and the actin cytoskeleton. Alix exists in monomeric and dimeric/multimeric configurations, but how dimer