Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yuzuru Minemoto"'
Autor:
Yukihito Ishizaka, Tsuneo Saga, Daisuke Kokuryo, Jun Hirose, Takayoshi Koyama, Yuzuru Minemoto, Kenji Kono, Sadahito Aoshima, Ichio Aoki, Misao Yoneyama, Shuhei Murayama, Rumiana Bakalova
Publikováno v:
Translational Research. 166(6):660-673
The objective of this study was to develop a thermotriggered, polymer-based liposomal drug carrier with an activatable magnetic resonance imaging (MRI) contrast property for monitoring the release of substances and for localized tumor therapy. The mu
Autor:
Shigeyuki Kano, Kenzo Tokunaga, Yuzuru Minemoto, Daiki Taneichi, Akihiro Doi, Takayoshi Koyama, Mari Shimura, Yukihito Ishizaka, Kenta Iijima
Publikováno v:
Journal of Neuroimmune Pharmacology. 6:177-187
Vpr, an accessory gene of human immunodeficiency virus type 1, encodes a virion-associated nuclear protein that plays an important role in the primary viral infection of resting macrophages. It has a variety of biological functions, including roles i
Autor:
Kenta Iijima, Akio Mimori, Yuzuru Minemoto, Yukihito Ishizaka, Shigeyuki Kano, Noriyuki Okudaira, Takayoshi Koyama
Publikováno v:
Proceedings of the National Academy of Sciences. 107:18487-18492
Long interspersed nucleotide element-1 (L1) is a retroelement comprising about 17% of the human genome, of which 80–100 copies are competent as mobile elements (retrotransposition: L1-RTP). Although the genetic structures modified during L1-RTP hav
Publikováno v:
Molecular Immunology. 44:2139-2143
The CD95 (Apo1/Fas)/CD95 ligand system plays pivotal roles in various aspects of immune regulation and function by triggering apoptosis. Besides the apoptosis signaling pathway, CD95 ligation also induces the activation of NF-kappaB. Previous studies
Publikováno v:
Molecular Cell. 21(4):467-480
Ultraviolet (UV) exerts its biological activities by activating downstream effectors, including NF-kappaB, JNK, and caspases. Activation of JNK is required for UV-induced apoptosis. It is unknown whether any crosstalk occurs between NF-kappaB and JNK
Autor:
Fangming Tang, Jialing Xiang, Anning Lin, Jiyan Zhang, Chenfei Yu, Truc N. Bui, Yuzuru Minemoto, Jing Liu
Publikováno v:
Molecular Cell. 13(3):329-340
JNK has been suggested to be proapoptotic, antiapoptotic, or have no role in apoptosis depending on the cell type and stimulus used. The precise mechanism of JNK action, under conditions when it promotes cell survival, is not entirely clear. Here, we
Autor:
Toshiyuki Sasagawa, Mari Shimura, Yukihito Ishizaka, Sanae Uchida, Masato Hirata, Katsumi Yamashita, Hitoshi Nakagama, Yuzuru Minemoto, Motoaki Ohtsubo
Publikováno v:
Archives of Biochemistry and Biophysics. 412:13-19
Most cell lines that lack functional p53 protein are arrested in the G2 phase of the cell cycle due to DNA damage. When the G2 checkpoint is abrogated, these cells are forced into mitotic catastrophe. A549 lung adenocarcinoma cells, in which p53 was
Autor:
Hitoshi Nakagama, Masaki Inoue, Yuzuru Minemoto, Yukito Masamune, Toshiyuki Sasagawa, Katsumi Yamashita, Julian Gannon, Mitsuko Masutani
Publikováno v:
Experimental Cell Research. 262:37-48
We investigated the effect of Adriamycin on FL-amnion (FL) cells. After treatment with the drug, the cells arrested at G2, but we did not detect an increase in the p21 levels. We established a p53-deficient derivative of these cells, in which G2 arre
Publikováno v:
Current HIV research. 7(2)
We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infec
Publikováno v:
Molecular cell. 21(4)
Ultraviolet (UV) exerts its biological activities by activating downstream effectors, including NF-kappaB, JNK, and caspases. Activation of JNK is required for UV-induced apoptosis. It is unknown whether any crosstalk occurs between NF-kappaB and JNK