Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yuzuru, Ninoyu"'
Autor:
Ely Cheikh Boussaty, Yuzuru Ninoyu, Leonardo R Andrade, Qingzhong Li, Ryu Takeya, Hideki Sumimoto, Takahiro Ohyama, Karl J Wahlin, Uri Manor, Rick A Friedman
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011211 (2024)
Age-related hearing loss (ARHL) is a common sensory impairment with complex underlying mechanisms. In our previous study, we performed a meta-analysis of genome-wide association studies (GWAS) in mice and identified a novel locus on chromosome 18 ass
Externí odkaz:
https://doaj.org/article/ac94d3baa66a4707867124f7352245ec
Autor:
Ely Cheikh Boussaty, Neil Tedeschi, Mark Novotny, Yuzuru Ninoyu, Eric Du, Clara Draf, Yun Zhang, Uri Manor, Richard H. Scheuermann, Rick Friedman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Age-related hearing loss (ARHL) is the most common cause of hearing loss and one of the most prevalent conditions affecting the elderly worldwide. Despite evidence from our lab and others about its polygenic nature, little is known about the specific
Externí odkaz:
https://doaj.org/article/fe06f769e4d24d9f9b0b1d86f5294812
Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology
Autor:
Eric Y. Du, Briana K. Ortega, Yuzuru Ninoyu, Robert W. Williams, Gary P. Cofer, James J. Cook, Kathryn J. Hornburg, Yi Qi, G. Allan Johnson, Rick A. Friedman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Numerous shown consequences of age-related hearing loss have been unveiled; however, the relationship of the cortical and subcortical structures of the auditory pathway with aging is not well known. Investigations into neural structure analysis remai
Externí odkaz:
https://doaj.org/article/6a8811bcadb44f6385348548acc67a51
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Inner ear macrophages play a vital role in cochlear homeostasis. Recent studies have demonstrated the existence of macrophages at different sites of the cochlea, with increased cochlear infiltration as an inflammatory response mechanism to injury. Ho
Externí odkaz:
https://doaj.org/article/8d0e6d9e732c494c9ba10500c875cc26
Autor:
Miguel A. Ramirez, Yuzuru Ninoyu, Cayla Miller, Leonardo R. Andrade, Seby Edassery, Ewa Bomba-Warczak, Briana Ortega, Uri Manor, Mark A. Rutherford, Rick A. Friedman, Jeffrey N. Savas
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104803- (2022)
Summary: Hearing depends on precise synaptic transmission between cochlear inner hair cells and spiral ganglion neurons through afferent ribbon synapses.Neuroligins (Nlgns) facilitate synapse maturation in the brain, but they have gone unstudied in t
Externí odkaz:
https://doaj.org/article/2d83c1d5d98a4ed9a50479488748c93e
Publikováno v:
Journal of International Advanced Otology, Vol 17, Iss 5, Pp 465-467 (2021)
Externí odkaz:
https://doaj.org/article/54a07b57b0aa4d1eaf78b179897750b4
Autor:
Boussaty, Ely Cheikh, Tedeschi, Neil, Novotny, Mark, Yuzuru Ninoyu, Du, Eric, Draf, Clara, Yun Zhang, Manor, Uri, Scheuermann, Richard H., Friedman, Rick
Publikováno v:
Frontiers in Cellular Neuroscience; 2023, p1-17, 17p
Autor:
Takashi Nakamura, Hirofumi Sakaguchi, Hiroaki Mohri, Yuzuru Ninoyu, Akihiro Goto, Taro Yamaguchi, Yoshitaka Hishikawa, Michiyuki Matsuda, Naoaki Saito, Takehiko Ueyama
Publikováno v:
Journal of Molecular Medicine.
Abstract Rac small GTPases play important roles during embryonic development of the inner ear; however, little is known regarding their function in cochlear hair cells (HCs) after specification. Here, we revealed the localization and activation of Ra
Autor:
Takehiko Ueyama, Yuzuru Ninoyu, Shin‐ya Nishio, Takushi Miyoshi, Hiroko Torii, Koji Nishimura, Kazuma Sugahara, Hideaki Sakata, Dean Thumkeo, Hirofumi Sakaguchi, Naoki Watanabe, Shin‐ichi Usami, Naoaki Saito, Shin‐ichiro Kitajiri
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 11, Pp 1310-1324 (2016)
Abstract DIAPH1 encodes human DIA1, a formin protein that elongates unbranched actin. The c.3634+1G>T DIAPH1 mutation causes autosomal dominant nonsyndromic sensorineural hearing loss, DFNA1, characterized by progressive deafness starting in childhoo
Externí odkaz:
https://doaj.org/article/8ba343c90b2e49b3816b0a1f746534e5
Autor:
Takashi Ishino, Daisuke Kikuchi, Toshinori Kubota, Noriko Ogasawara, Misako Hyogo, Chiharu Kihara, Tomoko Esaki, Satoshi Iwasaki, Jun Nakayama, Masahiro Takahashi, Yumiko Kobayashi, Yoh ichiro Iwasa, Masako Nakai, Yuika Sakurai, Mayuri Okami, Hidehiko Takeda, Sakiko Furutate, Nana Tsuchihashi, Yukihide Maeda, Marina Kobayashi, Hiroshi Yoshihashi, Tomoko Shintani, Tadao Yoshida, Tetsuo Ikezono, Hidekane Yoishimura, Shin-ichi Usami, Han Matsuda, Yasuhiro Arai, Yuko Kataoka, Kozo Kumakawa, Taisuke Kobayashi, Risa Tona, Kyoko Nagai, Shinya Morita, Akiko Sugaya, Yohei Honkura, Remi Motegi, Shuji Izumi, Hiroshi Yamazaki, Yasushi Naito, Shin-ya Nishio, Yuzuru Ninoyu, Hideaki Sakata, Yukihiko Kanda, Shinichiro Oka, Mayumi Suematsu
Publikováno v:
Human Genetics. 141:865-875
Mutations in the OTOF gene are a common cause of hereditary hearing loss and the main cause of auditory neuropathy spectrum disorder (ANSD). Although it is reported that most of the patients with OTOF mutations have stable, congenital or prelingual o