Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yuzuru, Itoh"'
Autor:
Takaaki A. Kobayashi, Hiroto Shimada, Fumiya K. Sano, Yuzuru Itoh, Sawako Enoki, Yasushi Okada, Tsukasa Kusakizako, Osamu Nureki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Vitamin C plays important roles as a cofactor in many enzymatic reactions and as an antioxidant against oxidative stress. As some mammals including humans cannot synthesize vitamin C de novo from glucose, its uptake from dietary sources is e
Externí odkaz:
https://doaj.org/article/f5a87d612bbc4dee96b6a0b432ab3cc5
Autor:
Vivek Singh, Yuzuru Itoh, Samuel Del’Olio, Asem Hassan, Andreas Naschberger, Rasmus Kock Flygaard, Yuko Nobe, Keiichi Izumikawa, Shintaro Aibara, Juni Andréll, Paul C. Whitford, Antoni Barrientos, Masato Taoka, Alexey Amunts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifi
Externí odkaz:
https://doaj.org/article/25b459b1c9f4493c81a55c314635cfbf
Autor:
Yuzuru Itoh, Vivek Singh, Anas Khawaja, Andreas Naschberger, Minh Duc Nguyen, Joanna Rorbach, Alexey Amunts
Publikováno v:
eLife, Vol 11 (2022)
The mitoribosome regulates cellular energy production, and its dysfunction is associated with aging. Inhibition of the mitoribosome can be caused by off-target binding of antimicrobial drugs and was shown to be coupled with a bilateral decreased visu
Externí odkaz:
https://doaj.org/article/71e26c92444548e79d73d278270bfc82
Autor:
Patrick Cottilli, Yuzuru Itoh, Yuko Nobe, Anton S. Petrov, Purificación Lisón, Masato Taoka, Alexey Amunts
Publikováno v:
Plant Communications, Vol 3, Iss 5, Pp 100342- (2022)
Protein synthesis in crop plants contributes to the balance of food and fuel on our planet, which influences human metabolic activity and lifespan. Protein synthesis can be regulated with respect to changing environmental cues via the deposition of c
Externí odkaz:
https://doaj.org/article/3edf429bdf4a4e71af9ca6e9bcefbd4e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Structural analyses of the translating mitoribosome from Neurospora crassa reveal insights into the interactions with mRNA and tRNA, assembly of the large subunit, and evolution of the tunnel for nascent polypeptide.
Externí odkaz:
https://doaj.org/article/e256947c606d41568f70372041d9abc0
Autor:
Anas Khawaja, Yuzuru Itoh, Cristina Remes, Henrik Spåhr, Olessya Yukhnovets, Henning Höfig, Alexey Amunts, Joanna Rorbach
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Translation within mitochondria relies upon specialized mitoribosomes and initiation factors. Here the authors use Cryo-EM and single molecule approaches to describe the early steps leading to translation initiation in human mitochondria, and the rol
Externí odkaz:
https://doaj.org/article/c511e0e642764f37845e6699bdca4970
Autor:
Kyoko Hanawa-Suetsugu, Yuzuru Itoh, Maisarah Ab Fatah, Tamako Nishimura, Kazuhiro Takemura, Kohei Takeshita, Satoru Kubota, Naoyuki Miyazaki, Wan Nurul Izzati Wan Mohamad Noor, Takehiko Inaba, Nhung Thi Hong Nguyen, Sayaka Hamada-Nakahara, Kayoko Oono-Yakura, Masashi Tachikawa, Kenji Iwasaki, Daisuke Kohda, Masaki Yamamoto, Akio Kitao, Atsushi Shimada, Shiro Suetsugu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The Bin/Amphiphysin/Rvs167 (BAR) domain superfamily, which includes FCH-BAR (F-BAR) domain proteins are membrane-sculpting proteins. Here the authors combine a range of techniques and show that the F-BAR domain of growth-arrest specific protein 7 (GA
Externí odkaz:
https://doaj.org/article/e2ed47610d894146b620955e644b5a77
Autor:
Neha Nirwan, Yuzuru Itoh, Pratima Singh, Sutirtha Bandyopadhyay, Kutti R. Vinothkumar, Alexey Amunts, Kayarat Saikrishnan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
McrBC is a bacterial antiphage defense system that cleaves methylated DNA and is composed of the AAA+ GTPase motor McrB and the endonuclease McrC. Here, the authors present the cryo-EM structure of E. coli McrBC that reveals how McrC inserts a stalk-
Externí odkaz:
https://doaj.org/article/5c68680d22bd42158914fb12b267b2bd
Autor:
Vivek Singh, Yuzuru Itoh, Samuel Del'Olio, Asem Hassan, Andreas Naschberger, Rasmus Kock Flygaard, Yuko Nobe, Keiichi Izumikawa, Shintaro Aibara, Juni Andrell, Paul Whitford, Antoni Barrientos, Masato Taoka, Alexey Amunts
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifications,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1efaf31ac006ac97aa3f9e165d32dd
https://doi.org/10.1101/2023.05.24.542018
https://doi.org/10.1101/2023.05.24.542018
Autor:
Ryoya Nakagawa, Hisato Hirano, Satoshi N. Omura, Suchita Nety, Soumya Kannan, Han Altae-Tran, Xiao Yao, Yuriko Sakaguchi, Takayuki Ohira, Wen Y. Wu, Hiroshi Nakayama, Yutaro Shuto, Tatsuki Tanaka, Fumiya K. Sano, Tsukasa Kusakizako, Yoshiaki Kise, Yuzuru Itoh, Naoshi Dohmae, John van der Oost, Tsutomu Suzuki, Feng Zhang, Osamu Nureki
Publikováno v:
Nature 616 (2023) 7956
Nature, 616(7956), 390-397
Nature, 616(7956), 390-397
The class 2 type V CRISPR effector Cas12 is thought to have evolved from the IS200/IS605 superfamily of transposon-associated TnpB proteins1. Recent studies have identified TnpB proteins as miniature RNA-guided DNA endonucleases2,3. TnpB associates w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3678c60506fb09e5ce6035ba20014725
https://research.wur.nl/en/publications/cryo-em-structure-of-the-transposon-associated-tnpb-enzyme
https://research.wur.nl/en/publications/cryo-em-structure-of-the-transposon-associated-tnpb-enzyme