Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Yuzhong Deng"'
Autor:
Martin Weber, Sang-Won Min, Tom Truong, Jeffrey Hung, Stephanie Dale, Mike Reichelt, Savita Ubhayakar, Carol Cain-Hom, Miriam Baca, Zhiyu Jiang, Qingling Li, Robert Brendza, Han Lin, Chung Kung, William F. Forrest, Cristine Quiason-Huynh, Wendy Sandoval, Buyun Chen, Yuzhong Deng, Amy Easton, Oded Foreman, Abdoulaye Sene, Baris Bingol
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop ocular phenotypes, we determined whether ocular phenotypes might result from impa
Externí odkaz:
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
Autor:
Jeffrey Hung, Buyun Chen, Robert Brendza, Zhiyu Jiang, William F. Forrest, Cristine M. Quiason-Huynh, Tom Truong, Savita Ubhayakar, Abdoulaye Sene, Carol Cain-Hom, Mike Reichelt, Oded Foreman, Martin Weber, Stephanie Dale, Amy Easton, Han Lin, Sang-Won Min, Qingling Li, Chung Kung, Baris Bingol, Miriam Baca, Yuzhong Deng, Wendy Sandoval
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop ocular phenotypes, we determined whether ocular phenotypes might result from impaired GCas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc9a3a93b3b95a4d22a4ff91dd3c1a3
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
Autor:
Karthik Nagapudi, Po-Chang Chiang, Jason R. Zbieg, Jia Liu, James J. Crawford, Emile Plise, Yuzhong Deng
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2256-2263
It is well acknowledged that the oral absorption of a drug can be influenced by its solubility, which is usually associated with its solid form properties. G1032 is a retinoic acid–related orphan receptor inverse agonist. Crystalline solid (form A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0e126d1d7d15f1da105815957b0987
https://doi.org/10.1016/j.xphs.2019.01.031
https://doi.org/10.1016/j.xphs.2019.01.031
Autor:
Thomas H. Pillow, Yuzhong Deng, Katherine R. Kozak, Peter S. Dragovich, Liling Liu, Robert T. Cass, Yichin Liu, S. Cyrus Khojasteh, Aimee Fourie-O'Donohue, Donglu Zhang, Jack Sadowsky, Cornelis E. C. A. Hop
Publikováno v:
Drug Metabolism and Disposition. 47:1156-1163
In cells, catalytic disulfide cleavage is an essential mechanism in protein folding and synthesis. However, detailed enzymatic catalytic mechanism relating cleavage of disulfide bonds in xenobiotics is not well understood. This study reports an enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e8affd3c247730a18fefcdc3bf9965
https://doi.org/10.1124/dmd.118.086132
https://doi.org/10.1124/dmd.118.086132
Autor:
Josep Tabernero, Yuzhong Deng, Andrés Cervantes, Vikram Malhi, Jian Huang, Premal Patel, Bianca M. Liederer, Raymond D. Meng, Nageshwar Budha, Luna Musib, Rucha Sane
Publikováno v:
Cancer chemotherapy and pharmacology. 88(6)
To examine the single- and multiple-dose pharmacokinetics (PK), CYP3A inhibition potential of ipatasertib, and effect of food on PK of ipatasertib in patients with refractory solid tumors and a dedicated food effect assessment in healthy subjects. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60990e06fb64b8d8cfb6a000c517ac4
https://pubmed.ncbi.nlm.nih.gov/34471960
https://pubmed.ncbi.nlm.nih.gov/34471960
Autor:
Nicholas Choong, Yuzhong Deng, Ilsung Chang, Sandhya Girish, Luna Musib, Ian Templeton, Sravanthi Cheeti, Kit Wun Kathy Cheung, Isabela Georgescu
Publikováno v:
Clinical Pharmacology in Drug Development
Cobimetinib is a kinase inhibitor indicated for use in combination with vemurafenib for treatment of unresectable/metastatic melanoma with specific BRAF mutations. Cobimetinib is extensively metabolized in liver; thus, patients with hepatic impairmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09689ac191d1cd71733df0ecf52f48ef
https://pubmed.ncbi.nlm.nih.gov/32696585
https://pubmed.ncbi.nlm.nih.gov/32696585
Autor:
Peter S. Dragovich, Sheila Ulufatu, John S. Wai, James Lee, Reginald Delarosa, Carl Ng, Zijin Xu, Chunjiao Chen, Shang-Fan Yu, S. Cyrus Khojasteh, Gail Lewis Phillips, Rebecca K. Rowntree, Keyang Xu, Aimee Fourie-O'Donohue, Zhonghua Pei, Isabel Figueroa, Liling Liu, Josefa dela Cruz-Chuh, Jiawei Lu, Jun Guo, Weiwei Jin, Jing Wang, Jinhua Chen, Eva Lin, Nicola J. Stagg, David Stokoe, Scott E. Martin, Trung Nguyen, Donglu Zhang, Hui Yao, Guangmin Li, Rachana Ohri, Thomas H. Pillow, Katherine R. Kozak, Brandon Latifi, Yuzhong Deng, Vishal Verma
Publikováno v:
Molecular Pharmaceutics. 15:3979-3996
A number of cytotoxic pyrrolobenzodiazepine (PBD) monomers containing various disulfide-based prodrugs were evaluated for their ability to undergo activation (disulfide cleavage) in vitro in the presence of either glutathione (GSH) or cysteine (Cys).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e6f9931e607d2a0302bf2150b678d
https://doi.org/10.1021/acs.molpharmaceut.8b00431
https://doi.org/10.1021/acs.molpharmaceut.8b00431
Autor:
Edna F. Choo, Scott Savage, Yang Gao, Brian Dean, Kelly Zhang, Pingping Lu, Dugan Freeman, Yuzhong Deng, Dennis Milanwoski, Buyun Chen, Kevin DeMent, Lichuan Liu
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 154:116-122
The pH labile metabolite, hydrophobicity, high oral dose and systematic exposure of GDC-0810 posed tremendous challenges to develop a LC–MS method for a stable isotope labeled aBA study. In this study, we explored practical solutions to balance sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d338a779e4351dfdc25056c962a90b49
https://doi.org/10.1016/j.jpba.2018.02.050
https://doi.org/10.1016/j.jpba.2018.02.050
Autor:
Yuzhong Deng, Hoangdung Ho, Jian Payandeh, Cornelis E. C. A. Hop, Ze Yang, Brian Dean, Xiaorong Liang, Yuan Chen, Buyun Chen, Liling Liu
Publikováno v:
The AAPS Journal. 19:1469-1478
Huge variation of drug transporter abundance was seen in the literature, making PBPK prediction difficult when transporters play a major role. Among multiple factors such as membrane fraction, digestion, and peptide selection that contributed to such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d92d45b6b60e2fe60b4ff5db6d771b5
https://doi.org/10.1208/s12248-017-0106-4
https://doi.org/10.1208/s12248-017-0106-4
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 369(3)
The ability of rodent immune-mediated arthritis models to quantitatively predict therapeutic activity of antiarthritis agents is poorly understood. Two commonly used preclinical models of arthritis are adjuvant-induced arthritis (AIA) and collagen-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d761790b127abb5f089bce3f0b9df5
https://pubmed.ncbi.nlm.nih.gov/30940693
https://pubmed.ncbi.nlm.nih.gov/30940693