A five amino acids deletion in NKCC2 of C57BL/6 mice affects analysis of NKCC2 phosphorylation but does not impact kidney function

Autor: Viktoria Fisi, Agnieszka Wengi, Dominique Loffing-Cueni, Robert A. Fenton, Marta Mariniello, James A. McCormick, Sandra Moser, Yuya Sugano, Johannes Loffing, Lena Lindtoft Rosenbaek

Publikováno v: Moser, S, Sugano, Y, Wengi, A, Fisi, V, Lindtoft Rosenbaek, L, Mariniello, M, Loffing-Cueni, D, McCormick, J A, Fenton, R A & Loffing, J 2021, ' A five amino acids deletion in NKCC2 of C57BL/6 mice affects analysis of NKCC2 phosphorylation but does not impact kidney function ', Acta Physiologica
, vol. 233, no. 1, e13705 . https://doi.org/10.1111/apha.13705
Acta Physiologica (Oxford, England)

Aim: The phosphorylation level of the furosemide-sensitive Na +-K +-2Cl − cotransporter (NKCC2) in the thick ascending limb (TAL) is used as a surrogate marker for NKCC2 activation and TAL function. However, in mice, analyses of NKCC2 phosphorylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c42f9acd9ff97476045a353660fa8e
https://pure.au.dk/portal/da/publications/a-five-amino-acids-deletion-in-nkcc2-of-c57bl6-mice-affects-analysis-of-nkcc2-phosphorylation-but-does-not-impact-kidney-function(3db88d28-8d8c-4c74-967b-c92ddbc167bb).html

Novel Transgenic Lines to Analyze Renal Glutathione Redox Potential In Vivo

Autor: Hugo Siegfried, Erin Merkel, Iain A. Drummond, Yuya Sugano

Publikováno v: Zebrafish. 17:153-155

Reactive oxygen species (ROS) are important regulators of intracellular signaling pathways in health and disease. It is implicated that ROS may play critical roles in pathogenesis of a number of kidney diseases including diabetic nephropathy. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d1f6fff5846df88ea5c0617a62bc0af
https://doi.org/10.1089/zeb.2020.1862

Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases.

Autor: Cardenas-Rodriguez, Magdalena, Austin-Tse, Christina, Bergboer, Judith G. M., Molinari, Elisa, Yuya Sugano, Bachmann-Gagescu, Ruxandra, Sayer, John A., Drummond, Iain A.

Publikováno v: Journal of Cell Science; Jul2021, Vol. 134 Issue 14, p1-13, 13p

Reverse genetics tools in zebrafish: A forward dive into endocrinology

Autor: Yuya Sugano, Stephan C.F. Neuhauss

Publikováno v: General and comparative endocrinology

The zebrafish is a powerful genetic model organism. In recent years, zebrafish has been increasingly used to model human diseases. Due to a number of recent technological advancements, the genetic tool box is now also stocked with sophisticated trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da203b8aaa7d0027884df41a4e1809a
https://doi.org/10.1016/j.ygcen.2013.02.002

MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and golgi architecture as a central mechanism in growth regulation

Autor: Christian Thiel, Andreas Giessl, Steffen Uebe, Kristin Kessler, Heinrich Sticht, Helmuth-Günther Dörr, Arif B. Ekici, Holger Blessing, Stephan C.F. Neuhauss, Yuya Sugano, Diana Zahnleiter, André Reis, Nadine N. Hauer

Numerous genes are involved in human growth regulation. Recently, autosomal-recessive inherited variants in centrosomal proteins have been identified in Seckel syndrome, primary microcephaly, or microcephalic osteodysplastic primary dwarfism. Common

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762649a0e12c4edc2e2b2509a398a446
https://www.zora.uzh.ch/id/eprint/104947/