Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins

Autor: Kohji Yamada, Yoshito Hannya, Tsunekazu Oikawa, Ayano Yoshida, Kuniko Katagiri, Saishu Yoshida, Rei Koizumi, Naoko Tago, Yuya Shimoyama, Akira Kawamura, Yuta Mochimaru, Ken Eto, Kiyotsugu Yoshida

Publikováno v: Molecules, Vol 28, Iss 10, p 4033 (2023)

Extended-synaptotagmin 1 (E-Syt1) is an endoplasmic reticulum membrane protein that is involved in cellular lipid transport. Our previous study identified E-Syt1 as a key factor for the unconventional protein secretion of cytoplasmic proteins in live

Externí odkaz: https://doaj.org/article/dfed7482292e4ad4a87b529df1a3e663

Data from Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer

Autor: Kiyotsugu Yoshida, Masaya Ono, Masayuki Saruta, Toshiaki Tachibana, Katsuhiko Aoki, Yuya Shimoyama, Chika Nakagawa, Chisato Saeki, Tomotaka Kumamoto, Saishu Yoshida, Saya Motohashi, Ryusuke Kizawa, Tsunekazu Oikawa, Kohji Yamada

Expression of human protein kinase C delta (PKCδ) protein has been linked to many types of cancers. PKCδ is known to be a multifunctional PKC family member and has been rigorously studied as an intracellular signaling molecule. Here we show that PK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08677ee13405558bdee369db15925078
https://doi.org/10.1158/0008-5472.c.6512445

Extracellular PKCδ signals to epidermal growth factor receptor for tumor proliferation in liver cancer cells

Autor: Kohji Yamada, Ryusuke Kizawa, Ayano Yoshida, Rei Koizumi, Saya Motohashi, Yuya Shimoyama, Yoshito Hannya, Saishu Yoshida, Tsunekazu Oikawa, Masayuki Shimoda, Kiyotsugu Yoshida

Publikováno v: Cancer Science. 113:2378-2385

Protein kinase C delta (PKCδ) is a multifunctional PKC family member and has been implicated in many types of cancers, including liver cancer. Recently, we have reported that PKCδ is secreted from liver cancer cells, and involved in cell proliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04685c842e033161d4f9efbe055bc16f
https://doi.org/10.1111/cas.15386

Evaluation of the Outcome of Local Surgery for Stomal Prolapse

Autor: Yasunobu Kobayashi, Seiichiro Eto, Tomotaka Kumamoto, Yuya Shimoyama, Yasuhiro Takeda, Masahisa Ohkuma, Makoto Kosuge, Takafumi Nakano, Hiroshi Sugano, Yuta Imaizumi, Muneyuki Koyama, Saori Yatabe, Yasuhiro Takano, Ken Eto, Naoki Takada

Publikováno v: Journal of Clinical Medicine, Vol 10, Iss 5438, p 5438 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 10; Issue 22; Pages: 5438

We reviewed the results of local surgical treatment of stoma prolapse, a long-term complication of stoma construction. Fifteen patients treated for stomal prolapse between 2009 and 2020 at the authors’ and affiliated hospitals were included in this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a434b67460e9e8efc5b4d6ae949e6890
https://www.mdpi.com/2077-0383/10/22/5438

Comparison of Strength of Anastomosis Between Four Different Techniques for Colorectal Surgery

Autor: Naoki Takada, Yuta Imaizumi, Kenta Tomori, Hiroshi Sugano, Tomotaka Kumamoto, Yuya Shimoyama, Katsuhiko Yanaga, Koichiro Haruki, Ken Eto

Publikováno v: Anticancer research. 40(4)

Background/aim Advances in stapling devices have led to their widespread use in colorectal surgery. We compared the strength of four types of anastomoses using bursting pressure. Materials and methods We created stapled anastomosis models [double sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd93db6227a5d955841ee35d6ddbac22
https://pubmed.ncbi.nlm.nih.gov/32234877