Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yuya Isoda"'
Autor:
Yuya Isoda, Kazumasa Ohtake, Wen Piao, Taiji Oashi, Fumika Kiku, Aiko Uchida, Masahiro Ikeda, Kazuhiro Masuda, Kensaku Sakamoto, Yasuhisa Shiraishi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Antibodies are widely used as therapeutic agents to tackle various diseases. In the present study, to enhance their clinical values, we rationally designed pH-responsivity by exploiting the idiosyncratic protonation/deprotonation profiles of
Externí odkaz:
https://doaj.org/article/b3974d48ef1640889cf0b0a808f2255b
Autor:
Yoshitake Sakae, Tadashi Satoh, Hirokazu Yagi, Saeko Yanaka, Takumi Yamaguchi, Yuya Isoda, Shigeru Iida, Yuko Okamoto, Koichi Kato
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins. In particular, core fu
Externí odkaz:
https://doaj.org/article/50ad649d668846048983c729179b56da
Autor:
Daisuke Shinmi, Ryosuke Nakano, Keisuke Mitamura, Minami Suzuki‐Imaizumi, Junko Iwano, Yuya Isoda, Junichi Enokizono, Yasuhisa Shiraishi, Emi Arakawa, Kazuma Tomizuka, Kazuhiro Masuda
Publikováno v:
Cancer Medicine, Vol 6, Iss 4, Pp 798-808 (2017)
Abstract Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been tested, to the best of our knowledge, there are currently
Externí odkaz:
https://doaj.org/article/bb89aaf8f1514e1dadc670cc4bef52df
Autor:
Yuya Isoda, Hirokazu Yagi, Tadashi Satoh, Mami Shibata-Koyama, Kazuhiro Masuda, Mitsuo Satoh, Koichi Kato, Shigeru Iida
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140120 (2015)
Antibody-dependent cellular cytotoxicity (ADCC) is an important effector function determining the clinical efficacy of therapeutic antibodies. Core fucose removal from N-glycans on the Fc portion of immunoglobulin G (IgG) improves the binding affinit
Externí odkaz:
https://doaj.org/article/1979f6e4fdcc478fbcbf5c219f94cd06
Publikováno v:
DSAA
To improve utilization of existing data assets in an enterprise, it is important to reduce the time required for data preparation, which is currently time-consuming for data scientists. In recent years, data catalogs have attracted attention as a sol
Autor:
Kazuma Tomizuka, Aiko Uchida, Junichi Enokizono, Yasuhisa Shiraishi, Yuya Isoda, Eri Taguchi, Kiyomi Yoshikawa, Junko Iwano, Shigeki Takaoka, Wen Piao, Emi Arakawa, Kazuhiro Masuda
Publikováno v:
Oncotarget
Photodynamic therapy (PDT) utilize a photosensitizing agent and light for cancer therapy. It exerts anti-cancer effect mainly by inducing vascular occlusion at the irradiated site. By controlling the irradiation area, PDT can be used in a tumor-speci
Autor:
Junichi Enokizono, Emi Arakawa, Ryosuke Nakano, Junko Iwano, Kazuhiro Masuda, Daisuke Shinmi, Keisuke Mitamura, Yuya Isoda, Minami Suzuki-Imaizumi, Yasuhisa Shiraishi, Kazuma Tomizuka
Publikováno v:
Cancer Medicine
Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been tested, to the best of our knowledge, there are currently no clinic
Autor:
Mami Shibata-Koyama, Mitsuo Satoh, Yuya Isoda, Emi Takemoto, Hirokazu Yagi, Koichi Kato, Kazuhiro Masuda, Shigeru Iida, Tsunehiro Mizushima
Publikováno v:
Genes to Cells
Removal of the fucose residue from the N-glycans of the Fc portion of immunoglobulin G (IgG) results in a dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC) through improved affinity for Fcγ receptor IIIa (FcγRIIIa). Here, we p
Autor:
Saeko Yanaka, Shigeru Iida, Yoshitake Sakae, Hirokazu Yagi, Yuko Okamoto, Takumi Yamaguchi, Tadashi Satoh, Koichi Kato, Yuya Isoda
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins. In particular, core fucosylatio
Autor:
Kazuhiro Masuda, Koichi Kato, Shigeru Iida, Mitsuo Satoh, Mami Shibata-Koyama, Tadashi Satoh, Yuya Isoda, Hirokazu Yagi
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140120 (2015)
PLoS ONE
PLoS ONE
Antibody-dependent cellular cytotoxicity (ADCC) is an important effector function determining the clinical efficacy of therapeutic antibodies. Core fucose removal from N-glycans on the Fc portion of immunoglobulin G (IgG) improves the binding affinit