Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yuxian Xiong"'
Autor:
Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Wenning Zhu, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism o
Externí odkaz:
https://doaj.org/article/e0b510d04f0846f9afbec3f3b04bc27e
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Ye, Xiong et al. present crystal structures of bacterial E3 ubiquitin ligase IpaH9.8 and IpaH9.8LRR–hGBP1. They find that substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of IpaH9.8. This study provides insights
Externí odkaz:
https://doaj.org/article/a1ceec4815714a919c357f452df6c888
Autor:
Yuxian Xiong, Bin Huang, Ying Yang, Xinming Fu, Ziyang Fu, Huidong Xu, Ming Liu, Dan Cao, Manman Zhang, Haibin Yang, Xiaogang Niu, Cong Yu, Hao Huang
Publikováno v:
Science Signaling. 16
Coronaviruses that can infect humans can cause either common colds (HCoV-NL63, HCoV-229E, HCoV-HKU1, and HCoV-OC43) or severe respiratory symptoms (SARS-CoV-2, SARS-CoV, and MERS-CoV). The papain-like proteases (PLPs) of SARS-CoV, SARS-CoV-2, MERS-Co
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING
Publikováno v:
Science Signaling. 16
The SARS-CoV-2 papain-like protease (PLpro), which has deubiquitinating activity, suppresses the type I interferon (IFN-I) antiviral response. We investigated the mechanism by which PLpro antagonizes cellular antiviral responses. In HEK392T cells, PL
Autor:
Dan Cao, Ziyang Fu, Jinle Tang, Yuxian Xiong, Yong Juan Zhao, Zhihong Liu, Guoliang Zhang, Jihui Li, Hao Huang, Huan Zhou, Ming Liu, Wenning Zhu, Bin Huang, Shuyan Liu, Yuxin Ye, Xiaogang Niu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus maturation, dysregulation of host inflammation, and antiviral immune respon
Autor:
Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease has been implicated in virus maturation, dysregulation of host inflammation and antiviral immune responses. We showed that PLpro preferably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f78589d342e21e7519c712edd0b2664
https://doi.org/10.1101/2020.07.17.208959
https://doi.org/10.1101/2020.07.17.208959
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
IpaH enzymes are bacterial E3 ligases targeting host proteins for ubiquitylation. Two autoinhibition modes of IpaH enzymes have been proposed based on the relative positioning of the Leucine-rich repeat domain (LRR) with respect to the NEL domain. In
A central theme in time perception research is whether subsecond timing relies on a dedicated centralized clock, or on distributed neural temporal dynamics. A fundamental constraint is the interval- and modality-specificity in perceptual learning of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e437d750e4eaf6316118e59654d0de