Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yuwen Linda, Lin"'
Autor:
Juan Jenny Li, Yuwen Linda Lin, Saileta Prabhu, Kevin Lin, Suzie J. Scales, Gizette Sperinde, Shan Chung, Kathi Williams, Saloumeh K Fischer, James A. Ernst, Kai Zheng, An Song, Siddharth Sukumaran, Julien Lafrance-Vanasse, Van Nguyen, Devin Tesar, Rong Deng, Greg A. Lazar
Publikováno v:
mAbs. 11:942-955
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd5cc1f2d9b349c5ce6517191eeda48
https://doi.org/10.1080/19420862.2019.1605270
https://doi.org/10.1080/19420862.2019.1605270
Publikováno v:
Journal of Immunological Methods. 462:101-105
The neonatal Fc receptor (FcRn) binds to the Fc domain of IgG in a pH-dependent manner, guides the intracellular movement of the bound antibodies and protects them from lysosomal degradation. Proper characterization of Fc-FcRn interactions is fundame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a4460635708065ba4ffbcf08ae6e45
https://doi.org/10.1016/j.jim.2018.07.004
https://doi.org/10.1016/j.jim.2018.07.004
Autor:
Shan, Chung, Van, Nguyen, Yuwen Linda, Lin, Julien, Lafrance-Vanasse, Suzie J, Scales, Kevin, Lin, Rong, Deng, Kathi, Williams, Gizette, Sperinde, Juan Jenny, Li, Kai, Zheng, Siddharth, Sukumaran, Devin, Tesar, James A, Ernst, Saloumeh, Fischer, Greg A, Lazar, Saileta, Prabhu, An, Song
Publikováno v:
mAbs
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b24934924be00d9ba5b5fc66744542b7
https://pubmed.ncbi.nlm.nih.gov/30982394
https://pubmed.ncbi.nlm.nih.gov/30982394
Autor:
Raymond K. Tong, Travis W. Bainbridge, Christoph Spiess, Y. Joy Yu Zuchero, Hok Seon Kim, Jasvinder Atwal, Randall J. Brezski, Jessica Couch, Megan Lo, Shan Chung, Mark S. Dennis, James A. Ernst, Yin Zhang, Jean-Michel Vernes, Yuwen Linda Lin, Y. Gloria Meng, Ryan J. Watts
Publikováno v:
The Journal of biological chemistry. 292(9)
The antibody Fc region regulates antibody cytotoxic activities and serum half-life. In a therapeutic context, however, the cytotoxic effector function of an antibody is often not desirable and can create safety liabilities by activating native host i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993d2b0b0421c3ca4eb6e3735db854b2
https://pubmed.ncbi.nlm.nih.gov/28077575
https://pubmed.ncbi.nlm.nih.gov/28077575
Publikováno v:
Journal of immunological methods. 447
In vitro antibody-dependent cell-mediated cytotoxicity (ADCC) assays are routinely performed to support the research and development of therapeutic antibodies. In ADCC assays, target cells bound by the antibodies are lysed by activated effector cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51078bfc84677e1060fcb8dd97d7da3
https://pubmed.ncbi.nlm.nih.gov/28434980
https://pubmed.ncbi.nlm.nih.gov/28434980
Autor:
Chung, Shan, Nguyen, Van, Lin, Yuwen Linda, Lafrance-Vanasse, Julien, Scales, Suzie J., Lin, Kevin, Deng, Rong, Williams, Kathi, Sperinde, Gizette, Li, Juan Jenny, Zheng, Kai, Sukumaran, Siddharth, Tesar, Devin, Ernst, James A., Fischer, Saloumeh, Lazar, Greg A., Prabhu, Saileta, Song, An
Publikováno v:
mAbs; Jul2019, Vol. 11 Issue 5, p942-955, 14p
Autor:
Megan Lo1,2,3, Hok Seon Kim4, Tong, Raymond K.1, Bainbridge, Travis W.1, Vernes, Jean-Michel5, Yin Zhang4, Yuwen Linda Lin6, Shan Chung6, Dennis, Mark S.4, Joy Yu Zuchero, Y.7, Watts, Ryan J.7, Couch, Jessica A.7,8, Meng, Y. Gloria5, Atwal, Jasvinder K.7, Brezski, Randall J.4, Spiess, Christoph4 spiess.christoph@gene.com, Ernst, James A.1,7 ernst.james@gene.com
Publikováno v:
Journal of Biological Chemistry. 3/3/2017, Vol. 292 Issue 9, p3900-3908. 9p.