Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Yuval Kluger"'
Autor:
Dijana Djureinovic, Sarah A. Weiss, Irina Krykbaeva, Rihao Qu, Ioannis Vathiotis, Myrto Moutafi, Lin Zhang, Ana L. Perdigoto, Wei Wei, Gail Anderson, William Damsky, Michael Hurwitz, Barbara Johnson, David Schoenfeld, Amit Mahajan, Frank Hsu, Kathryn Miller-Jensen, Yuval Kluger, Mario Sznol, Susan M. Kaech, Marcus Bosenberg, Lucia B. Jilaveanu, Harriet M. Kluger
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background Stimulating inflammatory tumor associated macrophages can overcome resistance to PD-(L)1 blockade. We previously conducted a phase I trial of cabiralizumab (anti-CSF1R), sotigalimab (CD40-agonist) and nivolumab. Our current purpos
Externí odkaz:
https://doaj.org/article/4fa1a648e79343f59ea5d04accc2e62b
Autor:
Fang Lyu, Chase Burzynski, Yuan yuan Fang, Aya Tal, Alice Y. Chen, Jacqueline Kisa, Kriti Agrawal, Yuval Kluger, Hugh S. Taylor, Reshef Tal
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
CXCR4 is a key regulator of the development of NK cells and DCs, both of which play an important role in early placental development and immune tolerance at the maternal-fetal interface. However, the role of CXCR4 in pregnancy is not well understood.
Externí odkaz:
https://doaj.org/article/e0dcd37ba2b541bd85c39ad2644c5b24
Publikováno v:
Entropy, Vol 26, Iss 3, p 258 (2024)
Ensuring robustness of image classifiers against adversarial attacks and spurious correlation has been challenging. One of the most effective methods for adversarial robustness is a type of data augmentation that uses adversarial examples during trai
Externí odkaz:
https://doaj.org/article/180a0bafd1484f2b93dadf1c6f337e4e
Autor:
Joanna Zyla, Anna Papiez, Jun Zhao, Rihao Qu, Xiaotong Li, Yuval Kluger, Joanna Polanska, Christos Hatzis, Lajos Pusztai, Michal Marczyk
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4663-4674 (2023)
Recent advances in sample preparation and sequencing technology have made it possible to profile the transcriptomes of individual cells using single-cell RNA sequencing (scRNA-Seq). Compared to bulk RNA-Seq data, single-cell data often contain a high
Externí odkaz:
https://doaj.org/article/c03801a5d24e494192c443cac632db19
Autor:
Rihao Qu, Yuval Kluger, Junchen Yang, Jun Zhao, David A. Hafler, Diane S. Krause, Alexey Bersenev, Marcus Bosenberg, Michael Hurwitz, Liliana Lucca, Harriet M. Kluger
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Abstract Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) is being studied in multiple tumor types. However, little is known about clonal cell expansion in vitro and persistence of the ACT product in vivo. We performed single-ce
Externí odkaz:
https://doaj.org/article/e09d03f52a094f57b08ab8aaea9a56a2
Autor:
Jan Martinek, Ryan C Fields, Scott Gettinger, Karolina Palucka, Katerina Politi, Jun Zhao, Ye Bi, Richard A Flavell, Frank Detterbeck, Obi Griffith, Liang Shan, Malachi Griffith, Michael Chiorazzi, Bradley Krasnick, Yunjiang Zheng, Keenan J Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A Henze, Frederic Brösecke, Adam Adonyi, Esen Sefik, Jacqueline Mudd, S Peter Goedegebuure, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Yuval Kluger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)
Background Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as
Externí odkaz:
https://doaj.org/article/9479165cf09946f8937b35f6027d8425
Autor:
Micha Sam Brickman Raredon, Junchen Yang, James Garritano, Meng Wang, Dan Kushnir, Jonas Christian Schupp, Taylor S. Adams, Allison M. Greaney, Katherine L. Leiby, Naftali Kaminski, Yuval Kluger, Andre Levchenko, Laura E. Niklason
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the function of tissues and organs. However, the quantification and visualization o
Externí odkaz:
https://doaj.org/article/667f51d390964320809ccc3bfb1c4a68
Autor:
George C. Linderman, Jun Zhao, Manolis Roulis, Piotr Bielecki, Richard A. Flavell, Boaz Nadler, Yuval Kluger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Missing values in scRNA-seq datasets can bias their analysis. Here, the authors threshold the low rank approximation of the expression matrix, so false zeros can be imputed while true zeros are preserved.
Externí odkaz:
https://doaj.org/article/f22657b2a43a4a529d2ffb2b9a0fba0e
Autor:
Shelli F. Farhadian, Ofir Lindenbaum, Jun Zhao, Michael J. Corley, Yunju Im, Hannah Walsh, Alyssa Vecchio, Rolando Garcia-Milian, Jennifer Chiarella, Michelle Chintanaphol, Rachela Calvi, Guilin Wang, Lishomwa C. Ndhlovu, Jennifer Yoon, Diane Trotta, Shuangge Ma, Yuval Kluger, Serena Spudich
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
People with HIV (PWH) on antiretroviral therapy (ART) experience elevated rates of neurological impairment, despite controlling for demographic factors and comorbidities, suggesting viral or neuroimmune etiologies for these deficits. Here, we apply m
Externí odkaz:
https://doaj.org/article/8d52c86ee987477d88bfffe03876da1a
Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Autor:
Tao Qing, Hussein Mohsen, Michal Marczyk, Yixuan Ye, Tess O’Meara, Hongyu Zhao, Jeffrey P. Townsend, Mark Gerstein, Christos Hatzis, Yuval Kluger, Lajos Pusztai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while a
Externí odkaz:
https://doaj.org/article/6465db3a292f40d4a8d14f8e7096e431