Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Yuuya Kasahara"'
Publikováno v:
Molecules, Vol 28, Iss 23, p 7911 (2023)
Enzymatic oligonucleotide synthesis is used for the development of functional oligonucleotides selected by in vitro selection. Expanding available sugar modifications for in vitro selection helps the functional oligonucleotides to be used as therapeu
Externí odkaz:
https://doaj.org/article/978f011dfb1d4899b9167269c88721f3
Autor:
Tomohiro Yamasaki, Takahiro Horie, Satoshi Koyama, Tetsushi Nakao, Osamu Baba, Masahiro Kimura, Naoya Sowa, Kazuhisa Sakamoto, Kazuhiro Yamazaki, Satoshi Obika, Yuuya Kasahara, Jun Kotera, Kozo Oka, Ryo Fujita, Takashi Sasaki, Akihiro Takemiya, Koji Hasegawa, Kenji Minatoya, Takeshi Kimura, Koh Ono
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Abdominal aortic aneurysm (AAA) is a lethal disease, but no beneficial therapeutic agents have been established to date. Previously, we found that AAA formation is suppressed in microRNA (miR)-33-deficient mice compared with wild-type mice.
Externí odkaz:
https://doaj.org/article/445284dacf4046649dd1ebec40553f4f
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 440-449 (2021)
Intracellular delivery of oligonucleotides is important for their use as therapeutic drugs. The conjugation of molecules interacting with cell membrane proteins to enhance their internalization into cells is an effective strategy for delivering oligo
Externí odkaz:
https://doaj.org/article/5f3d08e1a0944291bea47105a4434068
Autor:
Mitsuro Kanda, Yuuya Kasahara, Dai Shimizu, Takashi Miwa, Shinichi Umeda, Koichi Sawaki, Shunsuke Nakamura, Yasuhiro Kodera, Satoshi Obika
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 791-802 (2020)
Patients with peritoneal metastasis of gastric cancer have dismal prognosis, mainly because of inefficient systemic delivery of drugs to peritoneal tumors. We aimed to develop an intraperitoneal treatment strategy using amido-bridged nucleic acid (Am
Externí odkaz:
https://doaj.org/article/92531560c84e43a29c646adf1debc614
Autor:
Shinji Matsumoto, Taku Yamamichi, Koei Shinzawa, Yuuya Kasahara, Satoshi Nojima, Takahiro Kodama, Satoshi Obika, Tetsuo Takehara, Eiichi Morii, Hiroomi Okuyama, Akira Kikuchi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The mechanisms promoting hepatoblastoma (HB) progression through Wnt/β-catenin signaling are unclear. Here, the authors show that the Wnt/ β-catenin axis induces GREB1 expression and nuclear localization, and suppresses TGFβ pathway, and propose G
Externí odkaz:
https://doaj.org/article/9394e1f418b34459a5c6f905377fa254
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 888 (2021)
Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides. Chemical modification is an effective approach for improving the fun
Externí odkaz:
https://doaj.org/article/ceb400b8f3144db4a5402c5b5781c4f3
Autor:
Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
Publikováno v:
Molecules, Vol 25, Iss 7, p 1732 (2020)
Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective a
Externí odkaz:
https://doaj.org/article/4ce98c0bf38746ac93fee78a19bcd4db
Publikováno v:
Chemosensors, Vol 3, Iss 2, Pp 36-54 (2015)
Nucleic acids that change their properties upon photo-irradiation could be powerful materials for molecular sensing with high spatiotemporal resolution. Recently, we reported a photo-isomeric nucleoside bearing azobenzene at the C5 position of 2'-deo
Externí odkaz:
https://doaj.org/article/ab989b30003947319bed4b4477b96ede
Autor:
Naoki Sugimoto, Masayasu Kuwahara, Yuuya Kasahara, Shunsuke Kitadume, Hiroaki Ozaki, Yuri Imaizumi, Hiroto Fujita
Publikováno v:
Pharmaceuticals, Vol 6, Iss 9, Pp 1082-1093 (2013)
We recently selected DNA aptamers that bind to camptothecin (CPT) and CPT derivatives from a 70-mer oligodeoxyribonucleotide (ODN) library using the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method. The target-binding activity
Externí odkaz:
https://doaj.org/article/923a849ab45d404fbd68132d7fec0d7c
Autor:
Satoshi Obika, Akio Sugiyama, Hiroaki Sawai, Hiroaki Ozaki, Yuuya Kasahara, Hiroki Nara, Yuuki Takano, Masayasu Kuwahara
Publikováno v:
Molecules, Vol 15, Iss 11, Pp 8229-8240 (2010)
Recently, KOD and its related DNA polymerases have been used for preparing various modified nucleic acids, including not only base-modified nucleic acids, but also sugar-modified ones, such as bridged/locked nucleic acid (BNA/LNA) which would be prom
Externí odkaz:
https://doaj.org/article/24b88a9c81bd4045bc043bae26c6518f