Výsledky vyhledávání - "Yuuki Takaoka"

p15INK4bin HDAC inhibitor-induced growth arrest

Autor: Tomoya Yokota, Toshiyuki Sakai, Yuuki Takaoka, Youichirou Matsuzaki, Toshiaki Hitomi

Publikováno v: FEBS Letters. 554:347-350

Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin-dependent kinase inhibitor, p21(WAF1/Cip1). However, several studies have suggested the existence of a p21(WAF1/Cip1)-independent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09346861c2a74ffca1f8135b5d871ba
https://doi.org/10.1016/s0014-5793(03)01186-4

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A case of early-onset sarcoidosis with a six-base deletion in the NOD2 gene

Autor: Tomoki Kawai, Ikuo Okafuji, Yuuki Takaoka, Tatsutoshi Nakahata, Megumu K. Saito, Hidemasa Sakai, Toshio Heike, Takahiro Yasumi, Ryuta Nishikomori, Shusaku Ito

Publikováno v: Rheumatology. 49:194-196

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4b5b8f9e527901cc2406afcfcad13f0
https://doi.org/10.1093/rheumatology/kep315

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A Japanese case of familial Mediterranean fever with a MEFV gene mutation

Autor: Hidenobu, Kawabata, Manabu, Murakami, Ryuta, Nishikomori, Megumu, Saito, Yuuki, Takaoka, Kyoko, Nanao, Masaji, Maezawa

Publikováno v: [Hokkaido igaku zasshi] The Hokkaido journal of medical science. 84(6)

A 17-year-old Japanese male with a three-year history of recurrent episodic chest pain and fever, each lasting for one to three days, was diagnosed with familial Mediterranean fever (FMF) because of the following: 1) short attacks of chest pain and f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35c13450836978871a047a9397d87e89
https://pubmed.ncbi.nlm.nih.gov/19998717

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15-Deoxy-Δ12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor

Autor: Toshiaki Hitomi, Toshiyuki Sakai, Makoto Koyama, Youichirou Matsuzaki, Mayumi Kawanaka, Yuuki Takaoka

Publikováno v: International Journal of Oncology.

15-deoxy-Delta12, 14-prostaglandin J2 (15-d-PGJ2) inhibits cellular proliferation primarily in the G1 phase of the cell cycle. However, the molecular mechanism responsible for this effect has not been sufficiently elucidated. Here, we show that the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36896f4f80327f9cde733ca7a61a7988
https://doi.org/10.3892/ijo.27.2.497

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15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor

Autor: Youichirou, Matsuzaki, Makoto, Koyama, Toshiaki, Hitomi, Yuuki, Takaoka, Mayumi, Kawanaka, Toshiyuki, Sakai

Publikováno v: International journal of oncology. 27(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6446da9e70946113c4ad00632454d088
https://pubmed.ncbi.nlm.nih.gov/16010433

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Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c)

Autor: Toshiyuki Sakai, Toshiaki Hitomi, Hoyoku Nishino, Yuuki Takaoka, Youichirou Matsuzaki

Publikováno v: Oncogene. 23(31)

p18(INK4c), a member of INK4 family of cyclin-dependent kinase inhibitors, negatively regulates the cyclin D-cyclin-dependent kinase 4/6 complexes which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. Seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0714596699d3cb3c94fc311de96992b4
https://pubmed.ncbi.nlm.nih.gov/15107819

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