Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yuto Unoh"'
Autor:
Takahiro Kawajiri, Akihito Kijima, Atsuhiro Iimuro, Eisaku Ohashi, Katsuya Yamakawa, Kazushi Agura, Kengo Masuda, Kensuke Kouki, Koji Kasamatsu, Shuichi Yanagisawa, Sho Nakashima, Setsuya Shibahara, Takashi Toyota, Takafumi Higuchi, Takahiro Suto, Tadashi Oohara, Toshikatsu Maki, Naoto Sahara, Nobuaki Fukui, Hisayuki Wakamori, Hidaka Ikemoto, Hiroaki Murakami, Hiroyasu Ando, Masahiro Hosoya, Mizuki Sato, Yusuke Suzuki, Yuta Nakagawa, Yuto Unoh, Yoichi Hirano, Yoshitomo Nagasawa, Satoshi Goda, Takafumi Ohara, Takayuki Tsuritani
Publikováno v:
ACS Central Science, Vol 9, Iss 4, Pp 836-843 (2023)
Externí odkaz:
https://doaj.org/article/9f38b46b1b194cdaac85377b26776798
Autor:
Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Yukiko Yamatsu, Shiho Yamamoto, Yuki Maruyama, Yoshiyuki Taoda, Koji Kasamatsu, Takahiro Suto, Kensuke Kouki, Atsufumi Nakahashi, Sho Kawashima, Takao Sanaki, Shinsuke Toba, Kentaro Uemura, Tohru Mizutare, Shigeru Ando, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Takafumi Sato, Teruhisa Kato, Yuki Tachibana
Publikováno v:
Journal of Medicinal Chemistry. 65:6499-6512
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda3f19d8c44fa9a7e86dcee58fa2330
https://doi.org/10.1021/acs.jmedchem.2c00117
https://doi.org/10.1021/acs.jmedchem.2c00117
Autor:
Takahiro Kawajiri, Akihito Kijima, Atsuhiro Iimuro, Eisaku Ohashi, Katsuya Yamakawa, Kazushi Agura, Kengo Masuda, Kensuke Kouki, Koji Kasamatsu, Shuichi Yanagisawa, Sho Nakashima, Setsuya Shibahara, Takashi Toyota, Takafumi Higuchi, Takahiro Suto, Tadashi Oohara, Toshikatsu Maki, Naoto Sahara, Nobuaki Fukui, Hisayuki Wakamori, Hidaka Ikemoto, Hiroaki Murakami, Hiroyasu Ando, Masahiro Hosoya, Mizuki Sato, Yusuke Suzuki, Yuta Nakagawa, Yuto Unoh, Yoichi Hirano, Yoshitomo Nagasawa, Satoshi Goda, Takafumi Ohara, Takayuki Tsuritani
We describe the development of the practical manufacturing of Ensitrelvir, which was discovered as a SARS-CoV-2 antiviral candidate. Scalable synthetic methods of indazole, 1,2,4-triazole and 1,3,5-triazinone structures were established, and converge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe8efc31eb0dbe319232ced6f96b7a
https://doi.org/10.26434/chemrxiv-2022-wx3nl
https://doi.org/10.26434/chemrxiv-2022-wx3nl
Autor:
Shinsuke Toba, Akihiko Sato, Makoto Kawai, Yoshiyuki Taoda, Yuto Unoh, Shinji Kusakabe, Haruaki Nobori, Shota Uehara, Kentaro Uemura, Keiichi Taniguchi, Masanori Kobayashi, Takeshi Noshi, Ryu Yoshida, Akira Naito, Takao Shishido, Junki Maruyama, Slobodan Paessler, Michael J. Carr, William W. Hall, Kumiko Yoshimatsu, Jiro Arikawa, Keita Matsuno, Yoshihiro Sakoda, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Hiroshi Kida
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Viral hemorrhagic fevers caused by members of the order Bunyavirales comprise endemic and emerging human infections that are significant public health concerns. Despite the disease severity, there are few therapeutic options available, and therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfca5615a1abcdaf4cb99e387c3b5d6
https://pubmed.ncbi.nlm.nih.gov/36037386
https://pubmed.ncbi.nlm.nih.gov/36037386
Autor:
Yoshiyuki Taoda, Akihiko Sato, Shinsuke Toba, Yuto Unoh, Makoto Kawai, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 83:129175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76986ab5040219f53b49f36015789910
https://doi.org/10.1016/j.bmcl.2023.129175
https://doi.org/10.1016/j.bmcl.2023.129175
Publikováno v:
Advanced Synthesis & Catalysis. 361:2000-2003
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c5a7d51eda4ac59581786af875035e1
https://doi.org/10.1002/adsc.201900106
https://doi.org/10.1002/adsc.201900106
Publikováno v:
Chemistry - A European Journal. 24:13089-13092
A phosphenium-cation-mediated formal [3+2]-cycloaddition reaction of internal alkynes is reported. The reaction proceeds under metal-free conditions to give the corresponding C-P rearranged benzophospholes regioselectively, even when ortho- and para-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070a88e11d4aa1b8d1d1df48d74f00a2
https://doi.org/10.1002/chem.201803225
https://doi.org/10.1002/chem.201803225
Publikováno v:
Journal of the American Chemical Society. 139:6106-6109
A metal-free electrophilic phosphination reaction has been developed. Electrophilic phosphorus species generated in situ from secondary phosphine oxides and Tf2O smoothly couple with alkynes possessing pendant nucleophiles to afford the corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e318e246000f4cad860922dedf39b533
https://doi.org/10.1021/jacs.7b02977
https://doi.org/10.1021/jacs.7b02977
Publikováno v:
The Journal of Organic Chemistry. 81:2474-2481
The dehydrogenative annulation of thiophen-2-carboxamides with 2 equiv of alkynes proceeds efficiently in the presence of a rhodium catalyst and a copper oxidant to furnish multiply substituted benzo[c]thiophenes. Some of the synthesized benzo[c]thio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfd52ca4d6f318e354ab3c94e56fad1
https://doi.org/10.1021/acs.joc.6b00030
https://doi.org/10.1021/acs.joc.6b00030
Publikováno v:
ACS Catalysis. 5:6634-6639
The redox-neutral direct coupling of arylphosphine oxides with heterobicyclic alkenes proceeds smoothly under rhodium(III) catalysis involving hydroarylation followed by dehydrative aromatization to form biarylphosphine oxides. Related phenylphosphin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01d07346ff9c4760e87849ba14498468
https://doi.org/10.1021/acscatal.5b01896
https://doi.org/10.1021/acscatal.5b01896