Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Yutaro Kumagai"'
Autor:
Takumi Kishimoto, Ken Nishimura, Kana Morishita, Aya Fukuda, Yusaku Miyamae, Yutaro Kumagai, Kimio Sumaru, Mahito Nakanishi, Koji Hisatake, Masayuki Sano
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-18 (2024)
Abstract Background Viral vectors are attractive gene delivery vehicles because of their broad tropism, high transduction efficiency, and durable expression. With no risk of integration into the host genome, the vectors developed from RNA viruses suc
Externí odkaz:
https://doaj.org/article/c388b8ab39e64e45a019a45dd94f3471
Autor:
Yubo Zhang, Wenbo Yang, Yutaro Kumagai, Martin Loza, Weihang Zhang, Sung-Joon Park, Kenta Nakai
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Macrophages display extreme plasticity, and the mechanisms and applications of polarization and de-/repolarization of macrophages have been extensively investigated. However, the regulation of macrophage hysteresis after de-/repolarization remains un
Externí odkaz:
https://doaj.org/article/962d4203d85f4cad8ef6cc96f355d7e9
Autor:
Yoshihiro Miyazaki, Tatsuya Oda, Yuki Inagaki, Hiroko Kushige, Yutaka Saito, Nobuhito Mori, Yuzo Takayama, Yutaro Kumagai, Toutai Mitsuyama, Yasuyuki S. Kida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cancer-associated fibroblasts (CAFs) are the key components of the densely proliferated stroma in pancreatic ductal adenocarcinoma (PDAC) and contribute to tumor progression and drug resistance. CAFs comprise heterogeneous subpopulations pla
Externí odkaz:
https://doaj.org/article/4dd4de5030214100981257e70a7cbe46
Autor:
Erika Sugisawa, Takeshi Kondo, Yutaro Kumagai, Hiroki Kato, Yasunori Takayama, Kayako Isohashi, Eku Shimosegawa, Naoki Takemura, Yoshinori Hayashi, Takuya Sasaki, Mikaël M. Martino, Makoto Tominaga, Kenta Maruyama
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110462- (2022)
Summary: Nociceptors can fine-tune local or systemic immunity, but the mechanisms of nociceptive modulation in endotoxic death remain largely unknown. Here, we identified C-type lectin Reg3γ as a nociceptor-enriched hormone that protects the host fr
Externí odkaz:
https://doaj.org/article/eab16290279b42c39ee70f9d8694fbde
Autor:
Yukiko Imai, Nobuhito Mori, Yuma Nihashi, Yutaro Kumagai, Yoichiro Shibuya, Junya Oshima, Masahiro Sasaki, Kaoru Sasaki, Yukiko Aihara, Mitsuru Sekido, Yasuyuki S. Kida
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2388 (2022)
Scars are composed of stiff collagen fibers, which contract strongly owing to the action of myofibroblasts. To explore the substances that modulate scar contracture, the fibroblast-populated collagen lattice (FPCL) model has been used. However, the m
Externí odkaz:
https://doaj.org/article/7b9ea9c524ca47b5bd80fb1ea35762f2
Autor:
Kenta Maruyama, Hiroyasu Kidoya, Naoki Takemura, Erika Sugisawa, Osamu Takeuchi, Takeshi Kondo, Mohammed Mansour Abbas Eid, Hiroki Tanaka, Mikaël M. Martino, Nobuyuki Takakura, Yasunori Takayama, Shizuo Akira, Alexis Vandenbon, Yutaro Kumagai
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107906- (2020)
Summary: Zinc finger protein St18 was initially reported as candidate tumor suppressor gene, and also suggested that fibroblast St18 positively regulates NF-κB activation. Despite the pleiotropic functions of St18, little is known about its roles in
Externí odkaz:
https://doaj.org/article/39335951d565447b9f5690311309b724
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background The importance of transcription factors (TFs) and epigenetic modifications in the control of gene expression is widely accepted. However, causal relationships between changes in TF binding, histone modifications, and gene expressi
Externí odkaz:
https://doaj.org/article/c1e1cacddeaf4a85aff1b3af01cdc1fa
Autor:
Kenta Maruyama, Yasunori Takayama, Erika Sugisawa, Yu Yamanoi, Takashi Yokawa, Takeshi Kondo, Ken-ichi Ishibashi, Bikash Ranjan Sahoo, Naoki Takemura, Yuki Mori, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M. Martino, Yoshichika Yoshioka, Hisao Nishijo, Hiroki Tanaka, Atsushi Sasaki, Naohito Ohno, Yoichiro Iwakura, Yoshinori Moriyama, Masatoshi Nomura, Shizuo Akira, Makoto Tominaga
Publikováno v:
iScience, Vol 6, Iss , Pp 306-318 (2018)
Summary: Candida albicans infection can cause skin, vulvar, or oral pain. Despite the obvious algesic activity of C. albicans, the molecular mechanisms of fungal nociception remain largely unknown. Here we show that the C. albicans-specific signaling
Externí odkaz:
https://doaj.org/article/af790e5323b74bdb88c067532d689b01
Autor:
Kenta Maruyama, Yasunori Takayama, Takeshi Kondo, Ken-ichi Ishibashi, Bikash Ranjan Sahoo, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M. Martino, Hiroki Tanaka, Naohito Ohno, Yoichiro Iwakura, Naoki Takemura, Makoto Tominaga, Shizuo Akira
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2730-2742 (2017)
Candida albicans can enter skeletal tissue through a skin wound in an immunocompromised host or by contamination during orthopedic surgery. Such Candida osteomyelitis is accompanied by severe pain and bone destruction. It is established that nocicept
Externí odkaz:
https://doaj.org/article/1d2bc973c974426cb9cc52333f235fa0
Publikováno v:
Microorganisms, Vol 9, Iss 2, p 409 (2021)
The ltsA gene of Corynebacterium glutamicum encodes a purF-type glutamine-dependent amidotransferase, and mutations in this gene result in increased susceptibility to lysozyme. Recently, it was shown that the LtsA protein catalyzes the amidation of d
Externí odkaz:
https://doaj.org/article/d616f932fe39415c82ffaad5ef1c0865