Necl2/3-mediated mechanism for tripartite synapse formation

Autor: Osamu Nozawa, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Ryouhei Komaki, Tatsuhiro Shimizu, Toshihiko Kuriu, Yutaro Kashiwagi, Yuka Sato, Michinori Koebisu, Atsu Aiba, Shigeo Okabe, Kiyohito Mizutani, Yoshimi Takai

Publikováno v: Development. 150

Ramified, polarized protoplasmic astrocytes interact with synapses via perisynaptic astrocyte processes (PAPs) to form tripartite synapses. These astrocyte-synapse interactions mutually regulate their structures and functions. However, molecular mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eef7b1bf78bdc386c0bfde5ab0c94c9b
https://doi.org/10.1242/dev.200931

Imaging of spine synapses using super-resolution microscopy

Autor: Yutaro Kashiwagi, Shigeo Okabe

Publikováno v: Anatomical science international. 96(3)

Neuronal circuits in the neocortex and hippocampus are essential for higher brain functions such as motor learning and spatial memory. In the mammalian forebrain, most excitatory synapses of pyramidal neurons are formed on spines, which are tiny prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2ef43e492a828f82cc378ed0f3be2e
https://pubmed.ncbi.nlm.nih.gov/33459976

Computational geometry analysis of dendritic spines by structured illumination microscopy

Autor: Seth G. N. Grant, Shigeo Okabe, Yutaro Kashiwagi, Yuka Sato, Kazuki Obashi, Takahito Higashi, Noboru H. Komiyama

Publikováno v: Kashiwagi, Y, Higashi, T, Obashi, K, Sato, Y, Komiyama, N H, Grant, S G N & Okabe, S 2019, ' Computational geometry analysis of dendritic spines by structured illumination microscopy ', Nature Communications, vol. 10, no. 1 . https://doi.org/10.1038/s41467-019-09337-0
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Dendritic spines are the postsynaptic sites that receive most of the excitatory synaptic inputs, and thus provide the structural basis for synaptic function. Here, we describe an accurate method for measurement and analysis of spine morphology based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c8fc4bb2709fc23480f98414ffff59
https://doi.org/10.1038/s41467-019-09337-0

Temporal Sequences of Synapse Disintegration Triggered by Afferent Axon Transection, Time-Lapse Imaging Study of Presynaptic and Postsynaptic Molecules

Autor: Shigeo Okabe, Yutaro Kashiwagi, Takusei Cho

Publikováno v: eNeuro

Traumatic brain injury (TBI) is one of the major causes of death and disability. Multiple animal models have been developed to explore therapeutic targets for TBI. However, heterogeneity of pathophysiology obstructs discovery of therapeutic targets.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7b3be4f582491e01cffffba9255529
https://doi.org/10.1523/eneuro.0459-18.2019

LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites

Autor: Masamichi Ohkura, Anthony Wynshaw-Boris, Shigeo Okabe, Kazuki Obashi, Junichi Nakai, Yutaro Kashiwagi, Izumi Kawabata, Yuchio Yanagawa

Publikováno v: Nature Communications

Synaptic remodelling coordinated with dendritic growth is essential for proper development of neural connections. After establishment of synaptic contacts, synaptic junctions are thought to become stationary and provide fixed anchoring points for fur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5cc801c1a433977b85c6493ef6c3f3
https://doi.org/10.1038/ncomms1736