Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Yutaka Nakachi"'
Autor:
Hiroko Sugawara, Akitoshi Date, Satoshi Fuke, Yutaka Nakachi, Tadafumi Kato, Minoru Narita, Miki Bundo, Kazuya Iwamoto
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 250-255 (2024)
Abstract Quantifying cytosine modifications in various brain regions provides important insights into the gene expression regulation and pathophysiology of neuropsychiatric disorders. In this study, we quantified 5‐methylcytosine (5‐mC), 5‐hydr
Externí odkaz:
https://doaj.org/article/53b7f10946cf406ea9605263937b23d6
Autor:
Xichen Hu, Tadahito Yasuda, Noriko Yasuda-Yosihara, Atsuko Yonemura, Terumasa Umemoto, Yutaka Nakachi, Kohei Yamashita, Takashi Semba, Kota Arima, Tomoyuki Uchihara, Akiho Nishimura, Luke Bu, Lingfeng Fu, Feng Wei, Jun Zhang, Yilin Tong, Huaitao Wang, Kazuya Iwamoto, Takaichi Fukuda, Hayato Nakagawa, Koji Taniguchi, Yuji Miyamoto, Hideo Baba, Takatsugu Ishimoto
Publikováno v:
JHEP Reports, Vol 5, Iss 12, Pp 100892- (2023)
Background & Aims: Hepatocellular carcinoma (HCC) mainly develops from chronic hepatitis. Metabolic dysfunction-associated steatohepatitis (MASH) has gradually become the main pathogenic factor for HCC given the rising incidence of obesity and metabo
Externí odkaz:
https://doaj.org/article/866d6ebc777d4913969a931bf6ca5488
Autor:
Hitoshi Inoue, Masataka Hirasaki, Yasunao Kogashiwa, Yutaka Nakachi, Kiyomi Kuba, Yasuhiro Ebihara, Mitsuhiko Nakahira, Masanori Yasuda, Akihiko Okuda, Masashi Sugasawa
Publikováno v:
Clinical and Experimental Dental Research, Vol 9, Iss 4, Pp 711-720 (2023)
Abstract Objectives In recent years, an increase in oral cancer among elderly nonsmokers has been noted. The aim of this study was to identify novel oncogenes in oral cancer in older nonsmokers. Material and Methods Whole‐exome sequencing (WES) dat
Externí odkaz:
https://doaj.org/article/7e77489c7b04468b8fb6e115eadb1666
Autor:
Hiroko Sugawara, Miki Bundo, Takaoki Kasahara, Yutaka Nakachi, Junko Ueda, Mie Kubota-Sakashita, Kazuya Iwamoto, Tadafumi Kato
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract Bipolar disorder (BD) is a severe psychiatric disorder characterized by repeated conflicting manic and depressive states. In addition to genetic factors, complex gene–environment interactions, which alter the epigenetic status in the brain
Externí odkaz:
https://doaj.org/article/4e2ce5a08b574a38a809ce8dfba5f286
Autor:
Manabu Maeshiro, Satoru Shinriki, Rin Liu, Yutaka Nakachi, Yoshihiro Komohara, Yukio Fujiwara, Kazuaki Ohtsubo, Ryoji Yoshida, Kazuya Iwamoto, Hideki Nakayama, Hirotaka Matsui
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Once disseminated tumor cells (DTCs) arrive at a metastatic organ, they remain there, latent, and become seeds of metastasis. However, the clonal composition of DTCs in a latent state remains unclear. Here, we applied high-resolution DNA bar
Externí odkaz:
https://doaj.org/article/e68d442039ad4d76bd6f2a98e8a7ffa0
Autor:
Tempei Ikegame, Yosuke Hidaka, Yutaka Nakachi, Yui Murata, Risa Watanabe, Hiroko Sugawara, Tatsuro Asai, Emi Kiyota, Takeo Saito, Masashi Ikeda, Tsukasa Sasaki, Mamoru Hashimoto, Tomohisa Ishikawa, Minoru Takebayashi, Nakao Iwata, Chihiro Kakiuchi, Tadafumi Kato, Kiyoto Kasai, Miki Bundo, Kazuya Iwamoto
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract SLC6A4, which encodes the serotonin transporter, has a functional polymorphism called the serotonin transporter-linked polymorphic region (5-HTTLPR). The 5-HTTLPR consists of short (S) and long (L) alleles, each of which has 14 or 16 tandem
Externí odkaz:
https://doaj.org/article/17b9c7fc185445e79c6e9a586755ede8
Publikováno v:
Neuropsychopharmacology Reports, Vol 40, Iss 4, Pp 423-426 (2020)
Abstract Background Commercially available Illumina DNA methylation arrays (HumanMethylation 27K, HumanMethylation450, and MethylationEPIC BeadChip) can be used for comprehensive DNA methylation analyses of not only the human genome but also other ma
Externí odkaz:
https://doaj.org/article/0934bac1661749859d6b1c19a8202e55
Autor:
Jianbin Du, Yutaka Nakachi, Tomoki Kiyono, Shinya Fujii, Kiyoto Kasai, Miki Bundo, Kazuya Iwamoto
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Accumulating evidence suggests that the epigenetic alterations induced by antipsychotics contribute to the therapeutic efficacy. However, global and site-specific epigenetic changes by antipsychotics and those shared by different classes of antipsych
Externí odkaz:
https://doaj.org/article/6f9291070efd483385a1a105a03f85e7
Autor:
Yui Murata, Ayaka Fujii, Sho Kanata, Shinya Fujikawa, Tempei Ikegame, Yutaka Nakachi, Zhilei Zhao, Seiichiro Jinde, Kiyoto Kasai, Miki Bundo, Kazuya Iwamoto
Publikováno v:
Neuropsychopharmacology Reports, Vol 39, Iss 4, Pp 301-305 (2019)
Abstract Introduction Epigenetic information such as DNA methylation is a useful biomarker that reflects complex gene‐environmental interaction. Peripheral tissues such as blood and saliva are commonly collected as the source of genomic DNA in coho
Externí odkaz:
https://doaj.org/article/7f31428f6f654f17b0a1425cb0c280ec
Autor:
Masamitsu N. Asaka, Daichi Utsumi, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Yoshihiro Kawaoka, Keiji Kuba, Yasuhiro Yasutomi
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
COVID-19, caused by SARS-CoV-2, has spread worldwide with dire consequences. To urgently investigate the pathogenicity of COVID-19 and develop vaccines and therapeutics, animal models that are highly susceptible to SARS-CoV-2 infection are needed. In
Externí odkaz:
https://doaj.org/article/afea422794d241ba86355d7f4149ba23