Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Yutaka Mizushima"'
Publikováno v:
Allergology International, Vol 49, Iss 2, Pp 143-149 (2000)
Y-241 80 ((±)-4-(2-chloro-phenyl)-2-[2-(4-isobuthyl- phenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2f][1,2,4] triazolo[4,3-a)[1,4]diazepine) is a lipophilic platelet- activating factor (PAF) antagonist. In the present study, we incorporated Y-24180 into li
Externí odkaz:
https://doaj.org/article/cb4fd18046c143489a489354f696520c
Autor:
K. Pervin, A. Hasan, D. C. Dumonde, Yutaka Mizushima, Thomas M. Shinnick, R. Whiston, H. Direskeneli, Miles Stanford, Thomas Lehner, R van der Zee, A. Childerstone, E. Kasp
Publikováno v:
Stress Proteins in Medicine ISBN: 9781003067474
Behcet's disease (BD) was first described by Hippocrates in ancient Greece, and the disease is named after Hulusi Behcet, a Turkish dermatologist. It is a multisystem disorder with oral and genital ulcers, uveitis, and cutaneous, arthritic, and neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c551deaac279f8463e7319eb8076fa
https://doi.org/10.1201/9781003067474-10
https://doi.org/10.1201/9781003067474-10
Autor:
Takushi Namba, Shoji Kudoh, Tsutomu Ishihara, Keizo Sato, Yuichi Tasaka, Yukihiko Sugiyama, Yutaka Mizushima, Tohru Mizushima, Tomoaki Ishihara, Toshihiro Nukiwa, Masahito Ebina, Arata Azuma, Ken Ichiro Tanaka
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 298:L348-L360
Idiopathic pulmonary fibrosis (IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species (ROS), in particular superoxide anion, and fibrosis (collagen deposition). No treatment has been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ba1fe17a658a1d321b6b1fba2299e8
https://doi.org/10.1152/ajplung.00289.2009
https://doi.org/10.1152/ajplung.00289.2009
Publikováno v:
International Journal of Pharmaceutics. 385:170-175
We have prepared polymeric nanoparticles using a blend of poly(lactic acid) and monomethoxy-polyethyleneglycol(PEG)-polylactide block copolymer along with betamethasone disodium phosphate (BP). Nanoparticles have been screened for anti-inflammatory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b6a77e655389a02bdddf97c75aa607
https://doi.org/10.1016/j.ijpharm.2009.10.025
https://doi.org/10.1016/j.ijpharm.2009.10.025
Autor:
Haruka Sakamoto, Yoshinari Okamoto, Hiroshi Kiwada, Tsutomu Ishihara, Tatsuhiro Ishida, Ken Ichiro Tanaka, Naoki Yamakawa, Rie Igarashi, Miho Takeda, Tohru Mizushima, Yutaka Mizushima, Naoko Takasaki, Masami Otsuka, Chisa Kobayashi, Ayumi Kimoto, Kanae Yuki, Mitsuko Takenaga, Taishi Maeda
Publikováno v:
Pharmaceutical Research. 26:2270-2279
We recently developed prostaglandin E(1) (PGE(1))-encapsulated nanoparticles, prepared with a poly(lactide) homopolymer (PLA, Mw = 17,500) and monomethoxy poly(ethyleneglycol)-PLA block copolymer (PEG-PLA) (NP-L20). In this study, we tested whether t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf30aa6308a4d87ea8dd6f292fe688dc
https://doi.org/10.1007/s11095-009-9943-x
https://doi.org/10.1007/s11095-009-9943-x
Autor:
Kanae Kodera, Tsutomu Ishihara, Megumu Higaki, Hideko Kanazawa, Yutaka Mizushima, Maoko Goto, Yasuko Murakami
Publikováno v:
Drug Delivery. 16:153-159
To achieve the effective intracellular delivery of siRNA and silence specific genes, various types of conjugates between cell-penetrating peptides (CPPs; Transportan, Penetratin, Tat) and cationic peptides were developed. Uptake, intracellular locali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ed37a78d56c1a287039e2c3bebd885
https://doi.org/10.1080/10717540902722774
https://doi.org/10.1080/10717540902722774
Publikováno v:
International Journal of Pharmaceutics. 365:200-205
Solid nanoparticles consisting of biodegradable polymers have emerged as a promising carrier for various drugs, but unfortunately the encapsulation of drugs remains challenging. In this study, a technique for encapsulation of water-soluble drugs in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206c6f3ae8346983daea2347fe65c166
https://doi.org/10.1016/j.ijpharm.2008.08.030
https://doi.org/10.1016/j.ijpharm.2008.08.030
Autor:
Mitsuko Takenaga, Tsutomu Ishihara, Jun Suzuki, Keizo Sato, Toshifumi Hibi, Rie Igarashi, Takushi Namba, Yutaka Mizushima, Yuichi Tasaka, Tomoaki Ishihara, Ken Ichiro Tanaka, Tohru Mizushima, Susumu Okamoto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:152-164
Ulcerative colitis (UC) involves intestinal mucosal damage induced by reactive oxygen species (ROS), in particular, superoxide anion. Superoxide dismutase (SOD) catalyzes dismutation of superoxide anion to hydrogen peroxide, which is subsequently det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1ceb723136cec2f47869ed438ccf68
https://doi.org/10.1124/jpet.108.144451
https://doi.org/10.1124/jpet.108.144451
Autor:
Freerk Broeyer, Jacobus Burggraaf, Adam F. Cohen, Yutaka Mizushima, Jun Suzuki, Masato Takebe
Publikováno v:
The Journal of Clinical Pharmacology. 48:184-192
To study the pharmacokinetics of single increasing intravenous doses (40-160 mg) and repeated doses (80 mg for 7 days) of lecithinized superoxide dismutase (PC-SOD) in Japanese volunteers and to compare the pharmacokinetics of PC-SOD between Caucasia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106207bd4b945461e9ca1f9204c5069a
https://doi.org/10.1177/0091270007309705
https://doi.org/10.1177/0091270007309705
Drug-Supported Microparticles of Calcium Carbonate Nanocrystals and Its Covering with Hydroxyapatite
Autor:
Junzo Tanaka, Yutaka Mizushima, Hajime Watanaba, Toru Tonegawa, Guoping Chen, Toshiyuki Ikoma
Publikováno v:
Journal of Nanoscience and Nanotechnology. 7:822-827
Drug-supported spherical microparticles with below 3 microm in diameter of calcium carbonate (CC) nanocrystals were precipitated by a complex decomposition method from Na2CO3 and CaCl2 solutions with hydrocortisone phosphate (HyC). The HyC was comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf628d0341edbc0cc9e224aaf26e7172
https://doi.org/10.1166/jnn.2007.523
https://doi.org/10.1166/jnn.2007.523