Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Yutaka Kofuku"'
Autor:
Yutaro Shiraishi, Yutaka Kofuku, Takumi Ueda, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Arun K. Shukla, Ichio Shimada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
β-arrestins commonly bind to two distinct elements in GPCRs: the phosphorylated carboxyl terminal tail (C tail) and the cytoplasmic face of the transmembrane region (TM core). Here, the authors use methyl-TROSY NMR measurements to characterise the i
Externí odkaz:
https://doaj.org/article/c2744b4652694e1eb22b0a1f83faea09
Autor:
Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji, Sosuke Yoshinaga, Kazuhiro Okumura, Francis H. W. Shand, Yoshihiro Komohara, Mitsuhiro Takeda, Kana Kokubo, Ming-Chen Chen, Sana Yokoi, Hirofumi Rokutan, Yutaka Kofuku, Koji Ohnishi, Miki Ohira, Toshihiko Iizasa, Hirofumi Nakano, Takayoshi Okabe, Hirotatsu Kojima, Akira Shimizu, Shiro Kanegasaki, Ming-Rong Zhang, Ichio Shimada, Hiroki Nagase, Hiroaki Terasawa, Kouji Matsushima
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a r
Externí odkaz:
https://doaj.org/article/a4d75cebbb8f47a985d666129063bb6d
Autor:
Yutaro Shiraishi, Mei Natsume, Yutaka Kofuku, Shunsuke Imai, Kunio Nakata, Toshimi Mizukoshi, Takumi Ueda, Hideo Iwaï, Ichio Shimada
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Upon stimulation by agonist binding, the C-terminal regions of G-protein-coupled receptors (GPCRs) become phosphorylated by GPCR kinases, and phosphorylated GPCRs bind arrestin. Here the authors give structural insights into the phosphorylation induc
Externí odkaz:
https://doaj.org/article/11dca4d48ec6418dbf505466ac65a7b4
Autor:
Koh Takeuchi, Yutaka Kofuku, Shunsuke Imai, Takumi Ueda, Yuji Tokunaga, Yuki Toyama, Yutaro Shiraishi, Ichio Shimada
Publikováno v:
Membranes, Vol 11, Iss 8, p 604 (2021)
A primary biological function of multi-spanning membrane proteins is to transfer information and/or materials through a membrane by changing their conformations. Therefore, particular dynamics of the membrane proteins are tightly associated with thei
Externí odkaz:
https://doaj.org/article/399a52ea34974dbb844af3cc8f0e5f6e
Publikováno v:
Nihon Kessho Gakkaishi. 64:279-284
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851cb35a97307882841b56bf72d741f8
https://doi.org/10.5940/jcrsj.64.279
https://doi.org/10.5940/jcrsj.64.279
Publikováno v:
Nature Chemical Biology. 16:430-439
G-protein-coupled receptors (GPCRs) are seven-transmembrane proteins mediating cellular signals in response to extracellular stimuli. Although three-dimensional structures showcase snapshots that can be sampled in the process and nuclear magnetic res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38971dce764431d2a4cb03db0de5d51e
https://doi.org/10.1038/s41589-019-0457-5
https://doi.org/10.1038/s41589-019-0457-5
The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key physiological processes, and thus have long been attractive as drug targets. With crystal structure determinations of more than 50 different human GPCRs during the last de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454ab6c348b013fc57fc5ce93996f04b
https://doi.org/10.1142/9789811235795_0024
https://doi.org/10.1142/9789811235795_0024
Autor:
Ichio Shimada, Shunsuke Imai, Yuji Tokunaga, Takumi Ueda, Koh Takeuchi, Yutaka Kofuku, Yuki Toyama, Yutaro Shiraishi
Publikováno v:
Membranes
Membranes, Vol 11, Iss 604, p 604 (2021)
Membranes, Vol 11, Iss 604, p 604 (2021)
A primary biological function of multi-spanning membrane proteins is to transfer information and/or materials through a membrane by changing their conformations. Therefore, particular dynamics of the membrane proteins are tightly associated with thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2da6435e8956ea97e473ed33111b3c2
http://europepmc.org/articles/PMC8398610
http://europepmc.org/articles/PMC8398610
Autor:
Ichio Shimada, Masatoshi Kurita, Yutaro Shiraishi, Yutaka Kofuku, Keita Kondo, Takuya Mizumura, Mei Natsume, Takumi Ueda, Shunsuke Imai
Publikováno v:
Science Advances. 6
The lipid composition of the plasma membrane is a key parameter in controlling signal transduction through G protein-coupled receptors (GPCRs). Adenosine A2A receptor (A2AAR) is located in the lipid bilayers of cells, containing acyl chains derived f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15090f7e83c9c7ad52c20063c0bce01b
https://doi.org/10.1126/sciadv.aay8544
https://doi.org/10.1126/sciadv.aay8544
Autor:
Sana Yokoi, Takayoshi Okabe, Ichio Shimada, Toshihiko Iizasa, Etsuko Toda, Koji Ohnishi, Francis H. W. Shand, Shiro Kanegasaki, Hiroki Nagase, Meiji Itakura, Hirofumi Nakano, Mitsuhiro Takeda, Sosuke Yoshinaga, Miki Ohira, Ming-Rong Zhang, Kazuhiro Okumura, Yuya Terashima, Hirotatsu Kojima, Kana Kokubo, Ming Chen Chen, Mikiya Otsuji, Yoshihiro Komohara, Yutaka Kofuku, Hirofumi Rokutan, Hiroaki Terasawa, Kouji Matsushima, Akira Shimizu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target to control tumor-associated macrophages. The low level FROUNT expression in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5ea522550499798f4ebb8e0eda0242
https://doi.org/10.1038/s41467-020-14338-5
https://doi.org/10.1038/s41467-020-14338-5