Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yutaka Ikeno"'
Autor:
Ken Ichi Yoshida, Isao Yasumatsu, Takeshi Isoyama, Yumi Matsui, Fumie Tanzawa, Yutaka Ikeno, Shin Iimura, Hiroyuki Hanzawa, Takako Nawano, Osamu Ubukata, Hajime Fukano
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 74:156-160
Mitogen-activated protein kinase (MAPK)-interacting kinases 1 (Mnk1) and 2 (Mnk2) modulate translation initiation through the phosphorylation of eukaryotic translation initiation factor 4E, which promotes tumorigenesis. However, Mnk1 and Mnk2 are dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d1ccd2351348da24a25e43fba98d27
https://doi.org/10.1107/s2053230x18002108
https://doi.org/10.1107/s2053230x18002108
Publikováno v:
Biochemical and Biophysical Research Communications. 364:163-168
Sphingosylphosphorylcholine (SPC) is a choline-containing naturally occurring derivative of sphingolipid involved in various biological processes. Here we show that SPC displays neurotrophic effects in cerebellar granule neurons (CGNs) and in PC12 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3718800f5bb396296a8c03ccbcb317b6
https://doi.org/10.1016/j.bbrc.2007.09.121
https://doi.org/10.1016/j.bbrc.2007.09.121
Autor:
Katsuhiko Kitamoto, Simone Ottonello, Yutaka Ikeno, Manabu Arioka, So-hyun Cheon, Naoko Konno, Angelo Bolchi
Publikováno v:
Journal of Biological Chemistry. 280:28044-28052
We previously demonstrated that secretory phospholipase A2 (sPLA2) and lysophosphatidylcholine (LPC) exhibit neurotrophin-like neuritogenic activity in the rat pheochromocytoma cell line PC12. In this study, we further analyzed the mechanism whereby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e49f6924c7eed1778129fd24ea6250
https://doi.org/10.1074/jbc.m503343200
https://doi.org/10.1074/jbc.m503343200
Publikováno v:
FEBS Letters. 579:2693-2701
Cultured cerebellar granule neurons (CGNs) require membrane depolarization or neurotrophic factors for their survival in vitro and undergo apoptosis when deprived of these survival-promoting stimuli. Here, we show that secretory phospholipases A(2)s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52c03c4547d7061468fa7fd63c0ce0c
https://doi.org/10.1016/j.febslet.2005.03.092
https://doi.org/10.1016/j.febslet.2005.03.092
Autor:
Simone Ottonello, Tatsuya Yokoyama, Manabu Arioka, Satoru Nakashima, Katsuhiko Kitamoto, Angelo Bolchi, Masakazu Kuwana, Yutaka Ikeno
Publikováno v:
Biochemical Journal. 376:655-666
sPLA(2)s (secretory phospholipases A(2)) belong to a broad and structurally diverse family of enzymes that hydrolyse the sn -2 ester bond of glycerophospholipids. We previously showed that a secreted fungal 15 kDa protein, named p15, as well as its o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ddd25ecdd1b4833383065b17038193
https://doi.org/10.1042/bj20030830
https://doi.org/10.1042/bj20030830
Publikováno v:
Journal of neuroscience research. 87(1)
Cultured cerebellar granule neurons (CGNs) undergo apoptosis when deprived of depolarizing stimulation and provide an in vitro model system with which to study the effects of neurotrophic substances. Our previous results showed that secretory phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b364170da71911ef8065779e7ecfeb
https://pubmed.ncbi.nlm.nih.gov/18711725
https://pubmed.ncbi.nlm.nih.gov/18711725