Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yutaka Iigou"'
Autor:
Atsushi Satoh, Masao Tsubokawa, Jun Chiba, Fumito Muro, Nobuo Machinaga, Atsushi Nakayama, Yutaka Iigou, Shin Iimura, Yoshiyuki Yoneda, Gensuke Takayama, Tohru Takashi, Mika Yokoyama, Toshiyuki Watanabe
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1679-1693
A series of benzoic acid derivatives was synthesized as VLA-4 antagonists. Introduction of chlorine or bromine into the 3-position on the central benzene of the diphenylurea portion as in lead compound 2 led to improvement in the pharmacokinetic prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7f75fd64fcbfffa6081aaa2c8a0322
https://doi.org/10.1016/j.bmc.2006.12.006
https://doi.org/10.1016/j.bmc.2006.12.006
Autor:
Tohru Takashi, Mika Yokoyama, Jun Chiba, Fumito Muro, Takao Horiuchi, Yutaka Iigou, Tomomi Ogasawara, Nobuo Machinaga, Atsushi Nakayama, Shin Iimura, Yuichi Ochiai, Gensuke Takayama, Yoshiyuki Yoneda, Yoshimi Takata, Tomoe Taira, Yuichi Sugimoto, Masao Tsubokawa
Publikováno v:
Chemical and Pharmaceutical Bulletin. 54:1515-1529
A novel series of benzoic acid derivatives as VLA-4 antagonists were synthesized. Optimization, focusing on activity and lipophilicity needed for cell permeability, resulted in the identification of 15b and 15e with good activity (IC50 = 1.6 nM each)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b500c4c2d5a713262c292b29b04d0a
https://doi.org/10.1248/cpb.54.1515
https://doi.org/10.1248/cpb.54.1515
Autor:
Tomoe Taira, Yuuichi Sugimoto, Masaki Setoguchi, Atsushi Satoh, Nobuo Machinaga, Keiko Matsumoto, Yutaka Iigou, Yoshiyuki Yoneda, Fumihito Muro, Jun Chiba, Gensuke Takayama, Tohru Takashi, Mika Yokoyama, Toshiyuki Watanabe, Atsushi Nakayama, Shin Iimura
Publikováno v:
Journal of medicinal chemistry. 52(24)
We have focused on optimization of the inadequate pharmacokinetic profile of trans-4-substituted cyclohexanecarboxylic acid 5, which is commonly observed in many small molecule very late antigen-4 (VLA-4) antagonists. We modified the lipophilic moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a5b51ab26472225109f9623d1c4ac3
https://pubmed.ncbi.nlm.nih.gov/19891440
https://pubmed.ncbi.nlm.nih.gov/19891440
Autor:
Atsushi Nakayama, Gensuke Takayama, Yutaka Iigou, Shin Iimura, Nobuo Machinaga, Fumihito Muro, Tohru Takashi, Jun Chiba, Masaki Setoguchi, Mika Yokoyama, Toshiyuki Watanabe, Yoshiyuki Yoneda
Publikováno v:
Bioorganicmedicinal chemistry. 16(23)
Optimization of benzoic acid derivatives by introducing substituents into the diphenyl urea moiety led to the identification of compound 20l as a potent VLA-4 antagonist. Compound 20l inhibited eosinophil infiltration into bronchial alveolar lavage f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688c297f6cb706e7dc2e40b57ba0beca
https://pubmed.ncbi.nlm.nih.gov/18952443
https://pubmed.ncbi.nlm.nih.gov/18952443
Autor:
Hiroshi Serizawa, Makoto Suematsu, Yukio Suzuki, Kouichi Suzuki, Takuya Aoki, Yuzuru Ishimura, Kazumi Nishio, Harukuni Tsumura, Yutaka Iigou, Atsusi Miyata, Kazuhiro Yamaguchi
Publikováno v:
The American journal of physiology. 273(5)
This study aimed to examine the behavior of stimulated leukocytes in the pulmonary microcirculation. The leukocyte-endothelium interaction was visualized under physiological shear rates in perfused rat lungs using high-speed confocal laser video micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbbda03798d5decb583df6d9a74cdba
https://pubmed.ncbi.nlm.nih.gov/9374773
https://pubmed.ncbi.nlm.nih.gov/9374773
Autor:
Hidekazu Suzuki, Makoto Suematsu, Frank A. DeLano, Benjamin W. Zweifach, Takuya Tamatani, Geert W. Schmid-Schönbein, Yuzuru Ishimura, Masayuki Miyasaka, Reiji Kannagi, Michael J. Forrest, Yutaka Iigou
Publikováno v:
The Journal of clinical investigation. 96(4)
The present study was designed to elucidate whether molecular mechanisms for leukocyte adhesion to microvascular endothelium may differ between spontaneously hypertensive rats and Wistar Kyoto rats. Leukocyte rolling and adhesion were investigated wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3d3fde190292d868f6f5b142233c98
https://pubmed.ncbi.nlm.nih.gov/7560094
https://pubmed.ncbi.nlm.nih.gov/7560094