Výsledky vyhledávání - "Yutaka Hisada"

Akademický článek

A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro.

Autor: Takehisa Kawata, Shin Tokunaga, Miki Murai, Nami Masuda, Waka Haruyama, Youji Shoukei, Yutaka Hisada, Tetsuya Yanagida, Hiroshi Miyazaki, Michihito Wada, Tadao Akizawa, Masafumi Fukagawa

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0195316 (2018)

Cinacalcet hydrochloride (cinacalcet), an oral calcimimetic agent has been widely used for the management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD). In sharp contrast to vitamin D receptor activators, cinacalcet suppress

Externí odkaz: https://doaj.org/article/ac2d2caae5b94be0b3ff292f83e53552

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Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:2055-2060

The calcium-sensing receptor (CaSR) plays an important role in sensing extracellular calcium ions and regulating parathyroid hormone secretion by parathyroid gland cells, and the receptor is a suitable target for the treatment of hyperparathyroidism.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38595c9fa253c9741813c46283641921
https://doi.org/10.1016/j.bmcl.2018.04.055

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A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro

Autor: Masafumi Fukagawa, Takehisa Kawata, Yutaka Hisada, Tadao Akizawa, Tetsuya Yanagida, Michihito Wada, Miki Murai, Nami Masuda, Waka Haruyama, Youji Shoukei, Hiroshi Miyazaki, Shin Tokunaga

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0195316 (2018)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aab7cad4e87923044ec7940dcc0b32
https://doi.org/10.1371/journal.pone.0195316

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An Essential Role of Angiotensin II Receptor Type 1a in Recipient Kidney, Not in Transplanted Peripheral Blood Leukocytes, in Progressive Immune-Mediated Renal Injury

Autor: Yutaka Hisada, Akiyoshi Fukamizu, Kenjiro Kimura, Sumiko Tanaka, Yusuke Suzuki, Chisei Ra, Takeshi Sugaya

Publikováno v: Laboratory Investigation. 81:1243-1251

Despite an intensive effort of elucidating the pathogenic role of angiotensin II (AII) in immune-mediated renal injury, the precise mechanisms are poorly understood. In the present study, we examined the site of AII action, peripheral blood leukocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8f81b1e831630e0361450934b630d0
https://doi.org/10.1038/labinvest.3780338

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Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome

Autor: Takashi Yokoo, Yutaka Hisada, Toya Ohashi, Jin-Song Shen, Yoshikatsu Eto, Tatsuo Hosoya, Tetsuya Kawamura, Yasunori Utsunomiya

Publikováno v: Blood. 98:57-64

In chronic inflammation, macrophages and neutrophils, which are derived from bone marrow, play a pivotal role. Therefore, reconstitution of bone marrow with anti-inflammatory stem cells may modify inflammation. In this study, transplantation-based ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ba8bffcfd769289d1b48fd536576ee
https://doi.org/10.1182/blood.v98.1.57

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Anti-GBM glomerulonephritis in mice lacking IL-1β-converting enzyme (ICE)

Autor: Taroh Kogure, Takashi Yokoo, Tatsuo Hosoya, Toya Ohashi, Toshiyuki Imasawa, Makoto Ueno, Yasunori Utsunomiya, Yutaka Hisada, Tsuneya Ohno, Tetsuya Kawamura

Publikováno v: Clinical and Experimental Nephrology. 4:114-118

Background. Interleukin-1 (IL-1) has been reported to play a major role in the initiation and progression of several glomerulonephritis, and inhibition of IL-1 by the blockade of IL-1β-converting enzyme (ICE) has been suggested to be an ideal therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4886221e4c111c19d95a950974421a61
https://doi.org/10.1007/pl00012161

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Cell to Cell Interaction between Mesangial Cells and Macrophages Induces the Expression of Monocyte Chemoattractant Protein-1 through Nuclear Factor-κB Activation

Autor: Hiroaki Sakurai, Takeshi Sugaya, Yutaka Hisada

Publikováno v: Biochemical and Biophysical Research Communications. 269:309-316

The interaction between mesangial cells (MCs) and monocytes/macrophages (Mo/Mo) is an important pathogenic feature of glomerulonephritis. However, its mechanism is not fully elucidated. Studies to date have focused on the interactions through mediato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4a3a2e90c212b3a20b0c82138c1138
https://doi.org/10.1006/bbrc.2000.2297

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Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice

Autor: Kazuo Murakami, Hiromi Uchida, Hisako Fujimura, Akiyoshi Fukamizu, Yutaka Hisada, Hiroaki Sakurai, Takeshi Sugaya, Masaya Yamanouchi

Publikováno v: Scopus-Elsevier

Clinical and experimental studies indicate thatangiotensin II (AII) plays a pathophysiological role inthe progression of chronic renal diseases, especiallywhen hemodynamic abnormalities are involved (1).This concept is based on the observations thata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ebfc2e46425a7d469a193b108f96f3
https://doi.org/10.1172/jci2454

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Suppression of NF-κB and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: molecular mechanisms of anti-nephritic action

Autor: Keisuke Kawashima, Takahisa Sugita, Tohru Ishizuka, Yutaka Hisada, Hiroaki Sakurai, Noriko Shigemori

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1362(2-3):252-262

Transcription factors nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1) play an important role in the induction of pro-inflammatory factors such as cytokines and cell adhesion molecules, which could be involved in the pathogenesis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5b45324d9c309fe2da3fbce51bec70

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