Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yutaka Fukuma"'
Autor:
Eiko Sakai, Megumi Shimada-Sugawara, Yu Yamaguchi, Hiroshi Sakamoto, Reiko Fumimoto, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Takayuki Tsukuba
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 288-298 (2013)
Abstract.: Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor. We recently demonstrated that regu
Externí odkaz:
https://doaj.org/article/e236d81c6871433690c105523f5efb79
Autor:
Reiko Fumimoto, Eiko Sakai, Yu Yamaguchi, Hiroshi Sakamoto, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Takayuki Tsukuba
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 479-486 (2012)
Osteoclasts (OCLs) are multinucleated bone resorbing cells whose differentiation is regulated by receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). It is known that inflammatory cytokines and
Externí odkaz:
https://doaj.org/article/ce8b2a09de524a29ba289a05231fb530
Autor:
Kuniaki Okamoto, Shunsuke Komaki, Kazuhisa Nishishita, Takayuki Tsukuba, Yutaka Fukuma, Eiko Sakai
Publikováno v:
Biomedical Research. 39:169-177
Osteoclasts are multinucleated bone resorbing cells whose differentiation is regulated by several important signaling pathways. Several lines of evidence indicate that dihydroartemisinin (DHA), an anti-malarial drug, inhibits osteoclast differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d03b7f98aa95f290e86972e655ca2fc8
https://doi.org/10.2220/biomedres.39.169
https://doi.org/10.2220/biomedres.39.169
Autor:
Eiko Sakai, Yutaka Fukuma, Kuniaki Okamoto, Kazuhisa Nishishita, Shunsuke Komaki, Takayuki Tsukuba
Publikováno v:
Clinical and experimental pharmacologyphysiology. 45(8)
Rutaecarpine is a major alkaloid isolated from Evodia rutaecarpa. Here, we investigated the effects of rutaecarpine on osteoclast differentiation induced by macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κ-B li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d38e738f540e3088e95a17276ea765b
https://pubmed.ncbi.nlm.nih.gov/29582460
https://pubmed.ncbi.nlm.nih.gov/29582460
Autor:
Takayuki Tsukuba, Erika Yoneshima, Kuniaki Okamoto, Yutaka Fukuma, Kazuhisa Nishishita, Kaho Uchino, Eiko Sakai, Mayumi Iwatake
Publikováno v:
Phytotherapy Research. 29:1714-1721
Bone is constantly controlled by a balance between osteoblastic bone formation and osteoclastic bone resorption. Liquiritigenin is a plant-derived flavonoid and has various pharmacological effects, such as antioxidative, antitumor, and antiinflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::252941afe49dde9d578b178ef470ec1d
https://doi.org/10.1002/ptr.5416
https://doi.org/10.1002/ptr.5416
Publikováno v:
BioFactors. 41:222-231
Bone homeostasis is regulated by a balance between osteoclast (OCL)-mediated bone resorption and osteoblast (OBL)-mediated bone formation. Thus, developing a compound that simultaneously inhibits OCL function and promotes OBL function would be useful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::501c62fba592c2e2a07824eb8e850e67
https://doi.org/10.1002/biof.1218
https://doi.org/10.1002/biof.1218
Autor:
Kazuhisa Nishishita, Takayuki Tsukuba, Masahiro Ohuchi, Masayuki Yamamoto, Yutaka Fukuma, Masanobu Morita, Eiko Sakai, Mizuho A. Kido, Kuniaki Okamoto, Ken Itoh
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(9)
Kelch-like ECH-associated protein 1 (Keap1) binds to nuclear factor E2 p45-related factor 2 (Nrf2), a transcription factor for antioxidant enzymes, to suppress Nrf2 activation. The role of oxidative stress in many diseases supports the possibility th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd89e5202004dd4661c99755d1fbbd9
https://pubmed.ncbi.nlm.nih.gov/28515152
https://pubmed.ncbi.nlm.nih.gov/28515152
Autor:
Takayuki Tsukuba, Kazuhisa Nishishita, Eiko Sakai, Kuniaki Okamoto, Megumi Shimada-Sugawara, Reiko Fumimoto, Yu Yamaguchi, Hiroshi Sakamoto, Yutaka Fukuma
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 288-298 (2013)
Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor. We recently demonstrated that regulation of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29247b8714fd82da7afbb09070390b6a
http://www.sciencedirect.com/science/article/pii/S1347861319303573
http://www.sciencedirect.com/science/article/pii/S1347861319303573
Autor:
Eiko Sakai, Takayuki Tsukuba, Yu Yamaguchi, Hiroshi Sakamoto, Kuniaki Okamoto, Reiko Fumimoto, Kazuhisa Nishishita, Yutaka Fukuma
Publikováno v:
Journal of Applied Toxicology. 34:49-56
Osteoclasts (OCLs)are multinucleated bone-resorbing cells that are differentiated by receptor activator of nuclearfactor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). Our recent studies have shown thatheme-oxygenase-1 (HO-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae758bf1602c6f8214000fe29f9aa6f
https://doi.org/10.1002/jat.2827
https://doi.org/10.1002/jat.2827
Autor:
Haruna Matsushima, Takayuki Tsukuba, Kazuhisa Nishishita, Yutaka Fukuma, Eiko Sakai, Shun Narahara, Kuniaki Okamoto
Publikováno v:
Cell and Tissue Research. 348(1):81-94
Osteoclasts (OCLs) are multinucleated giant cells and are formed by the fusion of mononuclear progenitors of monocyte/macrophage lineage. It is known that macrophages derived from different genetic backgrounds exhibit quite distinct characteristics o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded644ee4e8bb43f88827bb7866878db
https://nagasaki-u.repo.nii.ac.jp/records/10612
https://nagasaki-u.repo.nii.ac.jp/records/10612