Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Yutaka Akiyama"'
Autor:
Mizuki Kobayashi, Akihiko Miyauchi, Eriko F. Jimbo, Natsumi Oishi, Shiho Aoki, Miyuki Watanabe, Yasushi Yoshikawa, Yutaka Akiyama, Takanori Yamagata, Hitoshi Osaka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Mitochondrial diseases are mainly caused by dysfunction of mitochondrial respiratory chain complexes and have a variety of genetic variants or phenotypes. There are only a few approved treatments, and fundamental therapies are yet to be deve
Externí odkaz:
https://doaj.org/article/e4636980387a48a3b5392e1c6ad4f86d
Autor:
Yuki Hosono, Satoshi Uchida, Moe Shinkai, Chad E. Townsend, Colin N. Kelly, Matthew R. Naylor, Hsiau-Wei Lee, Kayoko Kanamitsu, Mayumi Ishii, Ryosuke Ueki, Takumi Ueda, Koh Takeuchi, Masatake Sugita, Yutaka Akiyama, Scott R. Lokey, Jumpei Morimoto, Shinsuke Sando
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Naturally occurring peptides with high membrane permeability often have backbone ester bonds. Here, the authors investigated the effect of an amide-to-ester substitution on membrane permeability of peptides and found the substitution is useful for im
Externí odkaz:
https://doaj.org/article/a59489e908164722a8c86ea5023eb75f
Publikováno v:
Entropy, Vol 26, Iss 5, p 397 (2024)
Protein–ligand docking plays a significant role in structure-based drug discovery. This methodology aims to estimate the binding mode and binding free energy between the drug-targeted protein and candidate chemical compounds, utilizing protein tert
Externí odkaz:
https://doaj.org/article/076aad97e61e42179ee47cf7c82c7a7e
Autor:
Tadashi Miike, Hiroshi Kawakami, Takuro Kameda, Shojiro Yamamoto, Yoshihiro Tahara, Tomonori Hidaka, Yoko Kubuki, Kenji Yorita, Yutaka Akiyama, Yasuji Arimura, Yoshimasa Kubota, Hiroaki Kataoka, Kazuya Shimoda
Publikováno v:
BMC Gastroenterology, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1. The clinical course of ATLL is very heterogeneous, and many organs, including the gastrointestinal (GI) tract, c
Externí odkaz:
https://doaj.org/article/645c3aea58ef41a692b433b471d56e36
Publikováno v:
Journal of Medical Case Reports, Vol 14, Iss 1, Pp 1-6 (2020)
Abstract Background True thymic hyperplasia is a rare condition characterized by enlargement of the thymus while its normal structure is retained. True thymic hyperplasia is known to accompany Graves’ disease, but no association between true thymic
Externí odkaz:
https://doaj.org/article/18229023a011458d8f2988224bf87afa
Autor:
Koji Yamamoto, Yuichiro Sato, Yuudai Kondo, Hiroyuki Tanaka, Yutaka Akiyama, Yoshihiro Yamashita, Hiroaki Kataoka
Publikováno v:
Clinical Case Reports, Vol 7, Iss 10, Pp 1994-1998 (2019)
Abstract In multinodular lesions or tumors with mixed benign and malignant components, malignant elements may be undetectable using fine‐needle aspiration biopsy/cytology in preoperative pathological diagnosis of some cases, because of sampling err
Externí odkaz:
https://doaj.org/article/ef865a4c64a44e839cc2832d27dbf42f
Autor:
Takashi Tajimi, Naoki Wakui, Keisuke Yanagisawa, Yasushi Yoshikawa, Masahito Ohue, Yutaka Akiyama
Publikováno v:
BMC Bioinformatics, Vol 19, Iss S19, Pp 157-170 (2018)
Abstract Background Cyclic peptide-based drug discovery is attracting increasing interest owing to its potential to avoid target protein depletion. In drug discovery, it is important to maintain the biostability of a drug within the proper range. Pla
Externí odkaz:
https://doaj.org/article/0ed76e80a8bf45c2ad9982a5720bda3f
Publikováno v:
Biophysics and Physicobiology, Vol 17 (2020)
Protein functions can be predicted based on their three-dimensional structures. However, many multidomain proteins have unstable structures, making it difficult to determine the whole structure in biological experiments. Additionally, multidomain pro
Externí odkaz:
https://doaj.org/article/fbadf2f3fb01499498ae3aaac4469307
Publikováno v:
Entropy, Vol 24, Iss 3, p 354 (2022)
In the polyomino puzzle, the aim is to fill a finite space using several polyomino pieces with no overlaps or blanks. Because it is an NP-complete combinatorial optimization problem, various probabilistic and approximated approaches have been applied
Externí odkaz:
https://doaj.org/article/7aacd91ba3114e6b978631038904e691
Publikováno v:
BMC Bioinformatics, Vol 19, Iss S4, Pp 61-72 (2018)
Abstract Background Protein-protein interactions (PPIs) play several roles in living cells, and computational PPI prediction is a major focus of many researchers. The three-dimensional (3D) structure and binding surface are important for the design o
Externí odkaz:
https://doaj.org/article/7eda255d9da347c783d31a8a19ddba86