Výsledky vyhledávání - "Yutaka, Shizuta"

Identification of a Transcriptional Regulatory Factor for Human Aromatase Cytochrome P450 Gene Expression as Nuclear Factor Interleukin-6 (NF-IL6), a Member of the CCAAT/Enhancer-Binding Protein Family

Autor: Yasutake Yamamoto, Yutaka Shizuta, Hiroshi Sasaki, Shizuo Akira, Kozo Hashimoto, Katsumi Toda, Tadamitsu Kishimoto, Yusuke Sagara

Publikováno v: European Journal of Biochemistry. 231:292-299

Human aromatase cytochrome P450 catalyzes the ultimate reaction in the estrogen biosynthetic pathway by coupling with another enzyme, NADPH-cytochrome P450 reductase, in the endoplasmic reticulum. The expression of the gene encoding the enzyme (CYP19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d895ff3506187e0a5880ea3f11ef76
https://doi.org/10.1111/j.1432-1033.1995.0292e.x

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Steroid 11-Beta-Hydroxylase Deficiency Caused by Compound Heterozygosity for a Novel Mutation, p.G314R, in One CYP11B1 Allele, and a Chimeric CYP11B2/CYP11B1 in the Other Allele

Autor: Jan M. Wit, Bruce H. R. Wolffenbuttel, Yutaka Shizuta, Wilma Oostdijk, Guy Massa, Isao Kuribayashi, Koichi Honke, Satoshi Nomoto

Publikováno v: Hormone Research in Paediatrics. 63:284-293

Aims: Steroid 11β-hydroxylase deficiency (11β-OHD) is the second most common (5–8%) cause of congenital adrenal hyperplasia (CAH), and results from homozygous or compound heterozygous mutations or deletions of the responsible gene CYP11B1. In ord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a8c81832f680f0fe1011c6b33b15089
https://doi.org/10.1159/000087074

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Three Repeats of CCCCTCC on the Pyrimidine-rich Sequence in the Proximal 5′ Flanking Region are Required for Efficient Transcriptional Activity of the Human Endothelial Nitric Oxide Synthase Gene

Autor: Hideaki Kuge, Koichi Honke, Yutaka Shizuta, Kaoru Miyahara

Publikováno v: Free Radical Research. 38:87-95

The endothelial nitric-oxide synthase (eNOS) gene is constitutively expressed in endothelial cells, but numerous regulatory elements in the promoter region should contribute to the regulation for cell specific expression and the response to exogenous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03513fe1d5ae942ae5936e8f2270a788
https://doi.org/10.1080/10715160310001638029

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Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency

Autor: Yutaka Shizuta, K Saika, Kiyoshi Takeda, T Onishi, Katsumi Toda, Tetsuro Sugiura, M Nakagawa, Toshiji Saibara

Publikováno v: Journal of Endocrinology. 176:237-246

Aromatase (CYP19) is a cytochrome P450 enzyme that catalyzes the formation of aromatic C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex-specific differences in cellular metabolism. We have generated aromatas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d41268b99f4cb2f1cb782cf7e2a6ff
https://doi.org/10.1677/joe.0.1760237

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A Missense Mutation (GGC[435Gly]→AGC[Ser]) in Exon 8 of the CYP11B2 Gene Inherited in Japanese Patients with Congenital Hypoaldosteronism

Autor: Fumio Endo, Naohito Yamasaki, Yutaka Shizuta, Yoshinori Doi, Takashi Furuno, Romero Jovel Santa, Saburo Onishi, Isao Kuribayashi, Aldahoodi Ziyad Mutlaq, Toshiro Nakamura, Hideaki Kuge, Akio Takahashi, Shoichi Chida

Publikováno v: Hormone Research in Paediatrics. 60:255-260

Objectives: To clarify the underlying molecular mechanism of corticosterone methyl oxidase type II (CMO II) deficiency, Japanese patients newly diagnosed with CMO II deficiency were investigated. Methods: We analyzed the patients’ genomic DNA seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d89fb05b98ceca5f639fae5944a5c75c
https://doi.org/10.1159/000074041

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Dietary bisphenol A prevents ovarian degeneration and bone loss in female mice lacking the aromatase gene (Cyp19 )

Autor: Katsumi Toda, Teruhiko Okada, Chisato Miyaura, Yutaka Shizuta

Publikováno v: European Journal of Biochemistry. 269:2214-2222

We previously generated mice lacking aromatase activity by targeted disruption of Cyp19 (ArKO mice), and reported phenotypes of the female mice, showing hemorrhage formation and follicular depletion in the ovary, diminution in uterine size, and bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8469a799c76fdf5be4fd46947f394e0
https://doi.org/10.1046/j.1432-1033.2002.02879.x

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Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17β-estradiol or a peroxisome proliferator

Autor: Shizuo Akira, Saburo Onishi, Toshiji Saibara, Kiyoshi Takeda, Teruhiko Okada, Yutaka Shizuta, Katsumi Toda

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 79:11-17

We generated aromatase gene knockout mice (ArKO mice) by targeting disruption of Cyp19, which encodes an enzyme responsible for conversion of androgens to estrogens. We found that ArKO males developed hepatic steatosis spontaneously with aging, indic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6712ecb3541c6127809a66acc5c1e66
https://doi.org/10.1016/s0960-0760(01)00135-2

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Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17beta-oestradiol to aromatase gene (Cyp19) knockout mice

Autor: Saburo Onishi, Yutaka Shizuta, Katsumi Toda, Teruhiko Okada, Kiyoshi Takeda, Toshiji Saibara, M Shiraishi, Shizuo Akira

Publikováno v: Journal of Endocrinology. 168:455-463

Aromatase P450 (CYP19) is an enzyme responsible for the conversion of androgens to oestrogens. We generated CYP19 knockout (ArKO) mice by targeted disruption of Cyp19 and studied the role of oestrogens in male reproductive ability. Approximately 85%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db334f5d3e61be585518ed47c54a87b6
https://doi.org/10.1677/joe.0.1680455

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A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19)

Autor: Yutaka Shizuta, Katsumi Toda, Teruhiko Okada, Toshiji Saibara, Saburo Onishi

Publikováno v: Journal of Endocrinology. 168:217-220

Aromatase P450 (CYP19) is an enzyme responsible for conversion of androgens to oestrogens. We generated CYP19 knockout (ArKO) mice by targeting disruption of the CYP19 gene and observed that the ArKO males exhibited a complete loss of aggressive beha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d469fa2c26a2c7cfd97d4b377fc56b6
https://doi.org/10.1677/joe.0.1680217

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Altered expression of fatty acid–metabolizing enzymes in aromatase-deficient mice

Autor: Kiyomi Fujikawa-Adachi, Hideaki Enzan, Saburo Onishi, Masafumi Ono, Toshiji Saibara, Yoshihisa Nemoto, Teruhiko Okada, Yutaka Shizuta, Katsumi Toda

Publikováno v: Journal of Clinical Investigation. 105:1819-1825

Hepatic steatosis is a frequent complication in nonobese patients with breast cancer treated with tamoxifen, a potent antagonist of estrogen. In addition, hepatic steatosis became evident spontaneously in the aromatase-deficient (ArKO) mouse, which l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55be97e879faf1e846db03115e3a933
https://doi.org/10.1172/jci9575

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