Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Yutaka, Kitano"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Atopic dermatitis (AD) is one of the most prevalent intractable chronic itch diseases worldwide. In recent years, new molecular-targeted drugs have emerged, but side effects and economic challenges remain. Therefore, since it is importa
Externí odkaz:
https://doaj.org/article/824c3499d06c46ecbf4938ab3dff76f7
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neuropathic pain, an intractable pain symptom that occurs after nerve damage, is caused by the aberrant excitability of spinal dorsal horn (SDH) neurons. Gabapentinoids, the most commonly used drugs for neuropathic pain, inhibit spinal calcium-mediat
Externí odkaz:
https://doaj.org/article/58bfecee94504634ae8f75b76f78fd6b
Autor:
Hiroyasu Murasawa, Akiko Pawlak, Hiroyuki Kobayashi, Kensuke Saeki, Shun-ichi Yasuda, Yutaka Kitano
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111647- (2021)
Mirogabalin is a novel potent and selective ligand for the α2δ subunit of voltage-gated calcium channels, and shows potent and sustained analgesic effects in neuropathic pain and fibromyalgia models. Fibromyalgia is often associated with multiple c
Externí odkaz:
https://doaj.org/article/3816d7db5526435e853b41daa11028bc
Autor:
Yuki Domon, Naoko Kobayashi, Kazufumi Kubota, Yutaka Kitano, Hideaki Ueki, Yumiko Shimojo, Kayoko Ishikawa, Yuka Ofune
Publikováno v:
Drug Research. 73:54-60
Gabapentinoids are specific ligands for the α2δ-1 subunit of voltage-gated calcium channels. This class of drugs, including gabapentin and pregabalin, exert various pharmacological effects and are widely used for the treatment of epilepsy, anxiety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ac7122a33141cca154b897ab39ba2b
https://doi.org/10.1055/a-1941-8907
https://doi.org/10.1055/a-1941-8907
Autor:
Narayan Karanjule, Noriyuki Hayashi, Sayaka Suzuki, Toshifumi Tsuda, Eri Tokumaru, Kyosuke Tanaka, Hiroko Kimoto, Yuki Domon, Sakiko Takahashi, Kazufumi Kubota, Yutaka Kitano, Tomihisa Yokoyama, Ryuta Koishi, Chie Fujiwara, Shinichi Inaba, Daigo Asano, Tomoko Sakakura, Kiyoshi Takasuna, Tsuyoshi Shinozuka
Publikováno v:
ACS Medicinal Chemistry Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd20a57b9a34b89d6090c1968a55466
https://doi.org/10.1021/acsmedchemlett.3c00079
https://doi.org/10.1021/acsmedchemlett.3c00079
Autor:
Yutaka Kitano, Tsuyoshi Shinozuka
Publikováno v:
RSC Medicinal Chemistry. 13:895-920
The relationship between preclinical in vivo efficacy and NaV1.7 coverage among three types of VGSC inhibitors is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c6d3e685e41ca45594a45b5757ebbe
https://doi.org/10.1039/d2md00081d
https://doi.org/10.1039/d2md00081d
Autor:
Daisuke Kozai, Nobutaka Numoto, Kouki Nishikawa, Akiko Kamegawa, Shohei Kawasaki, Yoko Hiroaki, Katsumasa Irie, Atsunori Oshima, Hiroyuki Hanzawa, Kousei Shimada, Yutaka Kitano, Yoshinori Fujiyoshi
Publikováno v:
Journal of Molecular Biology. 435:168049
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e64105fb3791c387d4d9977b893d4ffe
https://doi.org/10.1016/j.jmb.2023.168049
https://doi.org/10.1016/j.jmb.2023.168049
Autor:
Yutaka, Kitano, Tsuyoshi, Shinozuka
Publikováno v:
RSC medicinal chemistry. 13(8)
The selective inhibition of Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fe3ce44ae64ba9b39a5d21857184a88
https://pubmed.ncbi.nlm.nih.gov/36092147
https://pubmed.ncbi.nlm.nih.gov/36092147
Publikováno v:
Frontiers in Molecular Neuroscience; 4/23/2023, Vol. 16, p1-13, 13p
Autor:
Hiroko Okuda, Atsuko Noguchi, Hatasu Kobayashi, Daiki Kondo, Kouji H Harada, Shohab Youssefian, Hirotomo Shioi, Risako Kabata, Yuki Domon, Kazufumi Kubota, Yutaka Kitano, Yasunori Takayama, Toshiaki Hitomi, Kousaku Ohno, Yoshiaki Saito, Takeshi Asano, Makoto Tominaga, Tsutomu Takahashi, Akio Koizumi
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154827 (2016)
Painful peripheral neuropathy has been correlated with various voltage-gated sodium channel mutations in sensory neurons. Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain
Externí odkaz:
https://doaj.org/article/806648927d904f768752537abf236d38